Search Results - "Artemyev, Nikolai O."

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor by Srivastava, Dhiraj, Gakhar, Lokesh, Artemyev, Nikolai O.

“…Resistance to inhibitors of cholinesterase 8A (Ric8A) is an essential regulator of G protein α-subunits (Gα), acting as a guanine nucleotide exchange factor…”
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The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx by Wang, Tian, Reingruber, Jürgen, Woodruff, Michael L., Majumder, Anurima, Camarena, Andres, Artemyev, Nikolai O., Fain, Gordon L., Chen, Jeannie

“…The retinal degeneration model rd10 contains a missense mutation of the catalytic PDE6 β subunit, which hydrolyzes cGMP in response to light. This model…”
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A Novel Role for UNC119 as an Enhancer of Synaptic Transmission by Fehlhaber, Katherine E, Majumder, Anurima, Boyd, Kimberly K, Griffis, Khris G, Artemyev, Nikolai O, Fain, Gordon L, Sampath, Alapakkam P

“…Mammalian UNC119 is a ciliary trafficking chaperone highly expressed in the inner segment of retinal photoreceptors. Previous research has shown that UNC119…”
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Extended conformation of the proline‐rich domain of human aryl hydrocarbon receptor‐interacting protein‐like 1: implications for retina disease by Yadav, Ravi P, Majumder, Anurima, Gakhar, Lokesh, Artemyev, Nikolai O.

“…Mutations in the primate‐specific proline‐rich domain (PRD) of aryl hydrocarbon receptor‐interacting protein‐like 1 (AIPL1) are thought to cause Leber…”
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Transducin translocation contributes to rod survival and enhances synaptic transmission from rods to rod bipolar cells by Majumder, Anurima, Pahlberg, Johan, Boyd, Kimberly K., Kerov, Vasily, Kolandaivelu, Saravanan, Ramamurthy, Visvanathan, Sampath, Alapakkam P., Artemyev, Nikolai O.

“…In rod photoreceptors, several phototransduction components display light-dependent translocation between cellular compartments. Notably, the G protein…”
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A truncated form of rod photoreceptor PDE6 β-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the γ-subunit by Manes, Gaël, Cheguru, Pallavi, Majumder, Anurima, Bocquet, Béatrice, Sénéchal, Audrey, Artemyev, Nikolai O, Hamel, Christian P, Brabet, Philippe

“…Autosomal dominant congenital stationary night blindness (adCSNB) is caused by mutations in three genes of the rod phototransduction cascade, rhodopsin (RHO),…”
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Transducin Partners Outside the Phototransduction Pathway by Srivastava, Dhiraj, Yadav, Ravi P., Inamdar, Shivangi M., Huang, Zhen, Sokolov, Maxim, Boyd, Kimberly, Artemyev, Nikolai O.

“…Transducin mediates signal transduction in a classical G protein-coupled receptor (GPCR) phototransduction cascade. Interactions of transducin with the…”
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Diffusion and light-dependent compartmentalization of transducin by Kerov, Vasily, Artemyev, Nikolai O.

“…Diffusion and light-dependent compartmentalization of transducin are essential for phototransduction and light adaptation of rod photoreceptors. Here,…”
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Intrinsically disordered γ-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure by Song, Jikui, Guo, Lian-Wang, Muradov, Hakim, Artemyev, Nikolai O, Ruoho, Arnold E, Markley, John L

“…The retinal phosphodiesterase (PDE6) inhibitory γ-subunit (PDEγ) plays a central role in vertebrate phototransduction through alternate interactions with the…”
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Reconstitution of the phosphodiesterase 6 maturation process important for photoreceptor cell function by Singh, Sneha, Srivastava, Dhiraj, Boyd, Kimberly, Artemyev, Nikolai O

“…The sixth family phosphodiesterases (PDE6) are principal effector enzymes of the phototransduction cascade in rods and cones. Maturation of nascent PDE6…”
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Characterization of Human Cone Phosphodiesterase-6 Ectopically Expressed in Xenopus laevis Rods by Muradov, Hakim, Boyd, Kimberly K., Haeri, Mohammad, Kerov, Vasily, Knox, Barry E., Artemyev, Nikolai O.

“…PDE6 (phosphodiesterase-6) is the effector molecule in the vertebrate phototransduction cascade. Progress in understanding the structure and function of PDE6…”
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Atypical retinal degeneration 3 in mice is caused by defective PDE6B pre-mRNA splicing by Muradov, Hakim, Boyd, Kimberly K., Kerov, Vasily, Artemyev, Nikolai O.

“…► Rod PDE6 protein and activity levels are markedly downregulated in atrd3 mice. ► The mutation-carrying exon 14 was spliced-out in the atrd3 PDE6B transcript…”
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Ric‐8A, a GEF, and a Chaperone for G Protein α‐Subunits: Evidence for the Two‐Faced Interface by Srivastava, Dhiraj, Artemyev, Nikolai O.

“…Resistance to inhibitors of cholinesterase 8A (Ric‐8A) is a prominent non‐receptor GEF and a chaperone of G protein α‐subunits (Gα). Recent studies shed light…”
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Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1 by Yadav, Ravi P., Boyd, Kimberly, Artemyev, Nikolai O.

“…Phosphodiesterase 6 (PDE6) is a key effector enzyme in vertebrate phototransduction, and its maturation and function are known to critically depend on a…”
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Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element by Srivastava, Dhiraj, Gowribidanur-Chinnaswamy, Pavithra, Gaur, Paras, Spies, Maria, Swaroop, Anand, Artemyev, Nikolai O

“…Two retinal transcription factors, cone-rod homeobox (CRX) and neural retina leucine zipper (NRL), cooperate functionally and physically to control…”
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Large-scale conformational rearrangement of the α5-helix of Gα subunits in complex with the guanine nucleotide exchange factor Ric8A by Srivastava, Dhiraj, Artemyev, Nikolai O.

“…Resistance to inhibitors of cholinesterase 8A (Ric8A) protein is an important G protein–coupled receptor (GPCR)-independent regulator of G protein α-subunits…”
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Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1 by Srivastava, Dhiraj, Yadav, Ravi P., Singh, Sneha, Boyd, Kimberly, Artemyev, Nikolai O.

“…Photoreceptor phosphodiesterase PDE6 is central for visual signal transduction. Maturation of PDE6 depends on a specialized chaperone complex of HSP90 with…”
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Interaction of the tetratricopeptide repeat domain of aryl hydrocarbon receptor–interacting protein–like 1 with the regulatory Pγ subunit of phosphodiesterase 6 by Yadav, Ravi P., Boyd, Kimberly, Yu, Liping, Artemyev, Nikolai O.

“…Phosphodiesterase-6 (PDE6) is key to both phototransduction and health of rods and cones. Proper folding of PDE6 relies on the chaperone activity of aryl…”
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Mechanisms of mutant PDE6 proteins underlying retinal diseases by Gopalakrishna, Kota N., Boyd, Kimberly, Artemyev, Nikolai O.

“…Mutations in PDE6 genes encoding the effector enzymes in rods and cones underlie severe retinal diseases including retinitis pigmentosa (RP), autosomal…”
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AIPL1: A specialized chaperone for the phototransduction effector by Yadav, Ravi P., Artemyev, Nikolai O.

“…Molecular chaperones play pivotal roles in protein folding, quality control, assembly of multimeric protein complexes, protein trafficking, stress responses,…”
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