Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter

Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter

Biogenic amines dopamine (DA) and serotonin (5-HT) are among the most significant monoaminergic neurotransmitters in the central nervous system (CNS). Separately, the physiological roles of DA and 5-HT have been studied in detail, and progress has been made in understanding their roles in normal and...

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Bibliographic Details
Published in:Biomedicines Vol. 11; no. 11; p. 2881
Main Authors: Traktirov, Dmitrii S, Nazarov, Ilya R, Artemova, Valeria S, Gainetdinov, Raul R, Pestereva, Nina S, Karpenko, Marina N
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-10-2023
Subjects:
Acids
addiction
Addictions
ADHD
Amines
Behavior
Biogenic amines
Cardiac glycosides
Cardiotonic agents
Central nervous system
Cerebellum
DAT-KO
Dopamine
Dopamine receptors
Dopamine transporter
Drug therapy
Enzymes
Hyperactivity
Medulla oblongata
Mental disorders
Mesencephalon
Metabolism
Metabolites
Movement disorders
mRNA
Neostriatum
Neurodegenerative diseases
Neurotransmission
Parkinson's disease
Phenols
Physiological aspects
Prefrontal cortex
RNA
Schizophrenia
Scientific equipment and supplies industry
Serotonin
Spinal cord
Statistical analysis
United States
Massachusetts
Russia
United States > US
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Summary:Biogenic amines dopamine (DA) and serotonin (5-HT) are among the most significant monoaminergic neurotransmitters in the central nervous system (CNS). Separately, the physiological roles of DA and 5-HT have been studied in detail, and progress has been made in understanding their roles in normal and various pathological conditions (Parkinson’s disease, schizophrenia, addiction, depression, etc.). In this article we showed that knockout of the gene encoding DAT leads not only to a profound dysregulation of dopamine neurotransmission in the striatum but also in the midbrain, prefrontal cortex, hippocampus, medulla oblongata and spinal cord. Furthermore, significant changes were observed in the production of mRNA of enzymes of monoamine metabolism, as well as to a notable alteration in the tissue level of serotonin, most clearly manifested in the cerebellum and the spinal cord. The observed region-specific changes in the tissue levels of serotonin and in the expression of dopamine and serotonergic metabolism enzymes in rats with an excess of dopamine can indicate important consequences for the pharmacotherapy of drugs that modulate the dopaminergic system. The drugs that affect the dopaminergic system could potently affect the serotonergic system, and this fact is important to consider when predicting their possible therapeutic or side effects.
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11112881