Content and transportation of Ca(2+) to hepatocytes and lipid content of liver cell membrane structure in experimental diabetes in the rat

It is proved that at experimental diabetes the calcium content in hepatocytes is disturbed. This disorder is mostly shown in increase of calcium content in hepatocytes and in decrease of accumulation of these ions in mitochondrias. One of the possible reasons of changes at this pathology is the chan...

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Bibliographic Details
Published in:	Ukrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 74; no. 5; p. 77
Main Authors:	Strutyns'ka, N A, Vasylevs'ka, V M, Dorozhyns'ka, L M, Artemenko, Ie I, Apukhovs'ka, L I, Kosterin, S O
Format:	Journal Article
Language:	Ukrainian
Published:	Ukraine 01-09-2002
Subjects:	Animals Biological Transport, Active - drug effects Calcifediol - antagonists & inhibitors Calcifediol - biosynthesis Calcium - metabolism Calcium - pharmacology Cell Membrane - chemistry Diabetes Mellitus, Experimental - metabolism Hepatocytes - chemistry Hepatocytes - metabolism Ion Transport - drug effects Membrane Lipids - analysis Microsomes - metabolism Mitochondria, Liver - metabolism Rats Rats, Wistar
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Summary:	It is proved that at experimental diabetes the calcium content in hepatocytes is disturbed. This disorder is mostly shown in increase of calcium content in hepatocytes and in decrease of accumulation of these ions in mitochondrias. One of the possible reasons of changes at this pathology is the change of lipid content of hepatocytes, mitochondrias and microsomes. It is proved that the in vitro model systems Ca ions inhibits the synthesis of 25-hydroxyvitamin D3 by hepatocytes.