Search Results - "Artelsmair, Markus"

Cucurbit[7]uril as a Supramolecular Artificial Enzyme for Diels–Alder Reactions by Palma, Aniello, Artelsmair, Markus, Wu, Guanglu, Lu, Xiaoyong, Barrow, Steven J., Uddin, Najib, Rosta, Edina, Masson, Eric, Scherman, Oren A.

“…The ability to mimic the activity of natural enzymes using supramolecular constructs (artificial enzymes) is a vibrant scientific research field. Herein, we…”
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New trends and applications in carboxylation for isotope chemistry by Bragg, Ryan A., Sardana, Malvika, Artelsmair, Markus, Elmore, Charles S.

“…Carboxylations are an important method for the incorporation of isotopically labeled 14CO2 into molecules. This manuscript will review labeled carboxylations…”
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Late-occurring and long-circulating metabolites of GABA A receptor modulator AZD7325 involving metabolic cyclization and aromatization: Relevance to mist analysis and application for patient compliance by Gu, Chungang (Chuck), Artelsmair, Markus, Elmore, Charles S., Davis, Patty, Hall, James E., Lewis, Richard J., Dembofsky, Bruce, Christoph, Greg, Ramaker, Michael, Smith, Mark A., Chapdelaine, Marc, Sunzel, Maria

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Cucurbit[7]uril as a Supramolecular Artificial Enzyme for Diels–Alder Reactions by Palma, Aniello, Artelsmair, Markus, Wu, Guanglu, Lu, Xiaoyong, Barrow, Steven J., Uddin, Najib, Rosta, Edina, Masson, Eric, Scherman, Oren A.

“…The ability to mimic the activity of natural enzymes using supramolecular constructs (artificial enzymes) is a vibrant scientific research field. Herein, we…”
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Computational Study of the Ir-Catalyzed Formation of Allyl Carbamates from CO 2 by Gahlawat, Sahil, Artelsmair, Markus, Castro, Abril C, Norrby, Per-Ola, Hopmann, Kathrin H

“…We have employed computational methods to investigate the iridium-catalyzed allylic substitution leading to the formation of enantioenriched allyl carbamates…”
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In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR by Bertarello, Andrea, Berruyer, Pierrick, Artelsmair, Markus, Elmore, Charles S, Heydarkhan-Hagvall, Sepideh, Schade, Markus, Chiarparin, Elisabetta, Schantz, Staffan, Emsley, Lyndon

“…The determination of intracellular drug concentrations can provide a better understanding of the drug function and efficacy. Ideally, this should be performed…”
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Computational Study of the Ir-Catalyzed Formation of Allyl Carbamates from CO2 by Gahlawat, Sahil, Artelsmair, Markus, Castro, Abril C., Norrby, Per-Ola, Hopmann, Kathrin H.

“…We have employed computational methods to investigate the iridium-catalyzed allylic substitution leading to the formation of enantioenriched allyl carbamates…”
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Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase by Ritzefeld, Markus, Zhang, Leran, Xiao, Zhangping, Andrei, Sebastian A., Boyd, Olivia, Masumoto, Naoko, Rodgers, Ursula R., Artelsmair, Markus, Sefer, Lea, Hayes, Angela, Gavriil, Efthymios-Spyridon, Raynaud, Florence I., Burke, Rosemary, Blagg, Julian, Rzepa, Henry S., Siebold, Christian, Magee, Anthony I., Lanyon-Hogg, Thomas, Tate, Edward W.

“…Hedgehog signaling is involved in embryonic development and cancer growth. Functional activity of secreted Hedgehog signaling proteins is dependent on…”
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Identification and In Vitro and In Vivo Characterization of KAC-50.1 as a Potential α‑Synuclein PET Radioligand by Saturnino Guarino, Dinahlee, Miranda Azpiazu, Patricia, Sunnemark, Dan, Elmore, Charles S., Bergare, Jonas, Artelsmair, Markus, Nordvall, Gunnar, Forsberg Morén, Anton, Jia, Zhisheng, Cortes-Gonzalez, Miguel, Mach, Robert H., Wilcox, Kyle C., Finnema, Sjoerd, Schou, Magnus, Varrone, Andrea

“…The accumulation of aggregated α-synuclein (α-syn) is a pathological hallmark of Parkinson’s disease (PD) and other synucleinopathies. Here within, we report…”
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Synthesis of C‐14 labeled GABAA α2/α3 selective partial agonists and the investigation of late‐occurring and long‐circulating metabolites of GABAA receptor modulator AZD7325 by Artelsmair, Markus, Gu, Chungang, Lewis, Richard J., Elmore, Charles S.

“…Anxiolytic activity has been associated with GABAA α2 and α3 subunits. Several target compounds were identified and required in C‐14 labeled form to enable a…”
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Late-occurring and Long-circulating Metabolites of GABA^sub Aα2,3^ Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance by Gu, Chungang, Artelsmair, Markus, Elmore, Charles S, Lewis, Richard J, Davis, Patty, Hall, James E, Dembofsky, Bruce T, Christoph, Greg, Smith, Mark A, Chapdelaine, Marc, Sunzel, Maria

“…AZD7325 [4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide] is a selective GABAAα2,3 receptor modulator intended for the treatment of…”
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Synthesis of C-14 labeled GABA A α2/α3 selective partial agonists and the investigation of late-occurring and long-circulating metabolites of GABA A receptor modulator AZD7325 by Artelsmair, Markus, Gu, Chungang, Lewis, Richard J, Elmore, Charles S

“…Anxiolytic activity has been associated with GABA α2 and α3 subunits. Several target compounds were identified and required in C-14 labeled form to enable a…”
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Synthesis, 3H‐labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2 by Artelsmair, Markus, Miranda‐Azpiazu, Patricia, Kingston, Lee, Bergare, Jonas, Schou, Magnus, Varrone, Andrea, Elmore, Charles S.

“…The immune system is implicated in the pathology of neurodegenerative disorders. The C‐C chemokine receptor 2 (CCR2) is one of the key targets involved in the…”
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Late-occurring and Long-circulating Metabolites of GABA A α 2,3 Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance by Gu, Chungang, Artelsmair, Markus, Elmore, Charles S, Lewis, Richard J, Davis, Patty, Hall, James E, Dembofsky, Bruce T, Christoph, Greg, Smith, Mark A, Chapdelaine, Marc, Sunzel, Maria

“…AZD7325 [4-amino-8-(2-fluoro-6-methoxyphenyl)- -propylcinnoline-3-carboxamide] is a selective GABA receptor modulator intended for the treatment of anxiety…”
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Synthesis, 3 H-labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2 by Artelsmair, Markus, Miranda-Azpiazu, Patricia, Kingston, Lee, Bergare, Jonas, Schou, Magnus, Varrone, Andrea, Elmore, Charles S

“…The immune system is implicated in the pathology of neurodegenerative disorders. The C-C chemokine receptor 2 (CCR2) is one of the key targets involved in the…”
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Late-occurring and long-circulating metabolites of GABAA receptor modulator AZD7325 involving metabolic cyclization and aromatization: Relevance to mist analysis and application for patient compliance by Gu, Chungang (Chuck), Artelsmair, Markus, Elmore, Charles S., Davis, Patty, Hall, James E., Lewis, Richard J., Dembofsky, Bruce, Christoph, Greg, Ramaker, Michael, Smith, Mark A., Chapdelaine, Marc, Sunzel, Maria

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Late-occurring and Long-circulating Metabolites of GABAAα2,3 Receptor Modulator AZD7325 Involving Metabolic Cyclization and Aromatization: Relevance to MIST Analysis and Application for Patient Compliance by Gu, Chungang, Artelsmair, Markus, Elmore, Charles S, Lewis, Richard J, Davis, Patty, Hall, James E, Dembofsky, Bruce T, Christoph, Greg, Smith, Mark A, Chapdelaine, Marc, Sunzel, Maria

“…AZD7325 [4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide] is a selective GABAAα2,3 receptor modulator intended for the treatment of…”
Get full text