Search Results - "Artasensi, Angelica"
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Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs
Published in Molecules (Basel, Switzerland) (23-04-2020)“…Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of population and according to the World Health Organization…”
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Obesity and Type 2 Diabetes: Adiposopathy as a Triggering Factor and Therapeutic Options
Published in Molecules (Basel, Switzerland) (30-03-2023)“…Obesity and type 2 diabetes (T2DM) are major public health concerns associated with serious morbidity and increased mortality. Both obesity and T2DM are…”
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A Novel Chromatographic Method to Assess the Binding Ability towards Dicarbonyls
Published in Molecules (Basel, Switzerland) (01-07-2023)“…Human exposure to dicarbonyls occurs via ingestion (e.g., food), inhalation (e.g., electronic cigarettes) and dysregulation of endogenous metabolic pathways…”
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2S-(1RS-benzyloxy-hex-5-enyl)-2,3-dihydro-1,4-benzodioxine
Published in MolBank (01-06-2024)“…In medicinal chemistry, the precise configuration of molecules is a crucial determinant of their pharmacological properties. Hence, the introduction of a new…”
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Exploring Secondary Amine Carnosine Derivatives: Design, Synthesis, and Properties
Published in Molecules (Basel, Switzerland) (28-10-2024)“…Carnosine is a naturally occurring dipeptide that has been advocated by some authors as an interesting scaffold for the development of potential therapeutic…”
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Back to Basics: Choosing the Appropriate Surface Disinfectant
Published in Antibiotics (Basel) (21-05-2021)“…From viruses to bacteria, our lives are filled with exposure to germs. In built environments, exposure to infectious microorganisms and their byproducts is…”
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Cyclo(His-Pro) Exerts Protective Carbonyl Quenching Effects through Its Open Histidine Containing Dipeptides
Published in Nutrients (23-04-2022)“…Cyclo(His-Pro) (CHP) is a cyclic dipeptide which is endowed with favorable pharmacokinetic properties combined with a variety of biological activities. CHP is…”
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(Z)-5-(3′,4′-Bis(benzyloxy)benzylidene)furan-2(5H)-one
Published in MolBank (2021)“…Over the years secondary metabolites have been considered as lead molecules both in their natural form and as templates for medicinal chemistry. Some secondary…”
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Candida albicans Biofilm Inhibition by Two Vaccinium macrocarpon (Cranberry) Urinary Metabolites: 5-(3′,4′-DihydroxyPhenyl)-γ-Valerolactone and 4-Hydroxybenzoic Acid
Published in Microorganisms (Basel) (13-07-2021)“…Candida spp. are pathobionts, as they can switch from commensals to pathogens, responsible for a variety of pathological processes. Adhesion to surfaces,…”
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Concise synthesis of deuterium-labelled proanthocyanidin metabolite 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone as an analytical tool
Published in RSC advances (14-02-2024)“…Deuterated proanthocyanidin metabolite 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone has been successfully produced. This metabolite is responsible for several…”
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Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as “Antidiabesity” Agents Based on Repurposing and Morphing of WB-4101
Published in Journal of medicinal chemistry (27-10-2022)“…The management of patients with type 2 diabetes mellitus (T2DM) is shifting from cardio-centric to weight-centric or, even better, adipose-centric treatments…”
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Evaluation of in vitro SARS‐CoV‐2 inactivation by a new quaternary ammonium compound: Bromiphen bromide
Published in Archiv der Pharmazie (Weinheim) (01-01-2024)“…The pneumonia (COVID‐19) outbreak caused by the novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which unpredictably…”
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How Reaction Conditions May Influence the Regioselectivity in the Synthesis of 2,3-Dihydro-1,4-benzoxathiine Derivatives
Published in Journal of organic chemistry (02-11-2018)“…The exploration of different reaction conditions aiming to obtain both 2,3-dihydro-1,4-benzoxathiine-2-yl derivatives and 2,3-dihydro-1,4-benzoxathiine-3-yl…”
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Profiling Vaccinium macrocarpon components and metabolites in human urine and the urine ex-vivo effect on Candida albicans adhesion and biofilm-formation
Published in Biochemical pharmacology (01-03-2020)“…[Display omitted] The aim of this work was to profile, by using an HPLC-MS/MS method, cranberry compounds and metabolites found in human urine after ingestion…”
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Chemoenzymatic approach towards the synthesis of the antitumor and antileishmanial marine metabolite (+)-Harzialactone A via the stereoselective, biocatalyzed reduction of a prochiral ketone
Published in Bioorganic chemistry (01-09-2023)“…[Display omitted] •New chemoenzymatic approach for the synthesis of (+)-Harzialactone A is proposed.•A collection of different promiscuous oxidoreductases…”
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