Search Results - "Artandi, S."

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice by DePinho, Ronald A, Artandi, Steven E, Chang, Sandy, Lee, Shwu-Luan, Alson, Scott, Gottlieb, Geoffrey J, Chin, Lynda

“…Aged humans sustain a high rate of epithelial cancers such as carcinomas of the breast and colon, whereas mice carrying common tumour suppressor gene mutations…”
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A critical role for telomeres in suppressing and facilitating carcinogenesis by Artandi, Steven E, DePinho, Ronald A

“…Progressive telomere shortening occurs with the division of primary human cells and activates tumor suppressor pathways, triggering senescence and inhibiting…”
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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis by Chin, Lynda, Artandi, Steven E, Shen, Qiong, Tam, Alice, Lee, Shwu-Luan, Gottlieb, Geoffrey J, Greider, Carol W, DePinho, Ronald A

“…Maintenance of telomere length and function is critical for the efficient proliferation of eukaryotic cells. Here, we examine the interactions between telomere…”
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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation by DePinho, Ronald A, Wong, Kwok-Kin, Chang, Sandy, Weiler, Sarah R, Ganesan, Shridar, Chaudhuri, Jayanta, Zhu, Chengming, Artandi, Steven E, Rudolph, Karl Lenhard, Gottlieb, Geoffrey J, Chin, Lynda, Alt, Frederick W

“…Telomeres are specialized nucleoprotein complexes that serve as protective caps of linear eukaryotic chromosomes. Loss of telomere function is associated with…”
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Inhibition of Transcriptional Regulator Yin-Yang-1 by Association with c-Myc by Shrivastava, A., Saleque, S., Kalpana, G. V., Artandi, S., Goff, S. P., Calame, K.

“…Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional…”
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Mice without telomerase: what can they teach us about human cancer? by Artandi, Steven E, DePinho, Ronald A

“…Unicellular organisms, human cells and mice have provided insights into the processes of senescence, crisis, genomic instability and cancer in humans. Here,…”
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Telomeres and telomerase in cancer by Artandi, Steven E., DePinho, Ronald A.

“…Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic events commandeer many signaling…”
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Polyamines alter sequence-specific DNA-protein interactions by Panagiotidis, Christos A., Artandi, Steven, Calame, Kathryn, Silverstein, Saul J.

“…The polyamines are abundant blogenlc cations implicated in many biological processes. Despite a plethora of evidence on polyamine-induced DNA conforma-tional…”
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YY1 and c-Myc Associate in vivo in a Manner that Depends on c-Myc Levels by Shrivastava, Ajay, Yu, Jin, Artandi, Steven, Calame, Kathryn

“…The c-Myc oncoprotein has previously been shown to associate with transcription regulator YY1 and to inhibit its activity. We show herein that endogenous c-Myc…”
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Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members by Hong, J. Y., Park, J., Cho, K., Gu, D., Ji, H., Artandi, S. E., McCrea, P. D.

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Mapping studies reveal unique epitopes on IgG recognized by rheumatoid arthritis-derived monoclonal rheumatoid factors by Bonagura, VR, Artandi, SE, Davidson, A, Randen, I, Agostino, N, Thompson, K, Natvig, JB, Morrison, SL

“…We have used chimeric IgG antibodies and their genetically engineered variants prepared by a combination of site-directed mutagenesis and exon exchange to…”
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Monoclonal IgM Rheumatoid Factors Bind IgG at a Discontinuous Epitope Comprised of Amino Acid Loops from Heavy-Chain Constant-Region Domains 2 and 3 by Artandi, S. E., Calame, K. L., Morrison, S. L., Bonagura, V. R.

“…A combination of site-directed mutagenesis and exon exchange has been used to further define the structure on IgG recognized by monoclonal IgM rheumatoid…”
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Oocyte telomerase levels correlate with blastocyst development by Kort, J.D., Garbuzov, A., Arand, J., Behr, B., Artandi, S.

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The basic helix-loop-helix-zipper domain of TFE3 mediates enhancer-promoter interaction by Artandi, S E, Cooper, C, Shrivastava, A, Calame, K

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization by ROMAN, C, MATERA, A. G, COOPER, C, ARTANDI, S, BLAIN, S, WARD, D. C, CALAME, K

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TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription by Artandi, Steven E., Merrell, Kevin, Avitahl, Nicole, Wong, Kwok-Kin, Calame, Kathryn

“…TFE3 is a basic-helix-loop-helix-zipper (bHLHZIP) domain-containing protein that binds μE3 sites in regulatory elements in the immunoglobulin heavy chain gene…”
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Molecular analysis of IgM rheumatoid factor binding to chimeric IgG by Artandi, SE, Canfield, SM, Tao, MH, Calame, KL, Morrison, SL, Bonagura, VR

“…To localize regions on IgG bound by rheumatoid factors (RF), we studied IgM RF binding to chimeric IgG antibodies consisting of murine V regions fused to human…”
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Mapping rheumatoid factor binding sites using genetically engineered, chimeric IgG antibodies by Bonagura, V R, Artandi, S E, Agostino, N, Tao, M H, Morrison, S L

“…We are using chimeric IgG antibodies consisting of murine variable regions joined to human constant regions as rheumatoid factor (RF) binding substrates to…”
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Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly by Venteicher, Andrew S., Meng, Zhaojing, Mason, Philip J., Veenstra, Timothy D., Artandi, Steven E.

“…Telomerase is a multisubunit ribonucleoprotein (RNP) complex that adds telomere repeats to the ends of chromosomes. Three essential telomerase components have…”
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The Protein Subunit of Telomerase Is Downregulated with Normal Myeloid Differentiation, but Reactivated in Leukemic Progenitors by Jamieson, Catriona, Gilison, D., Allsopp, R., Weissman, I., Artandi, S.

“…Telomeres are comprised of TTAGGG nucleotide repeats and a large protein complex that together protect chromosomal ends. Telomeres shorten progressively with…”
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