Search Results - "Artamonov, Mykhaylo V."

A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells by Billaud, Marie, Chiu, Yu-Hsin, Lohman, Alexander W, Parpaite, Thibaud, Butcher, Joshua T, Mutchler, Stephanie M, DeLalio, Leon J, Artamonov, Mykhaylo V, Sandilos, Joanna K, Best, Angela K, Somlyo, Avril V, Thompson, Roger J, Le, Thu H, Ravichandran, Kodi S, Bayliss, Douglas A, Isakson, Brant E

“…Both purinergic signaling through nucleotides such as ATP (adenosine 5'-triphosphate) and noradrenergic signaling through molecules such as norepinephrine…”
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Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure by DeLalio, Leon J, Keller, Alexander S, Chen, Jiwang, Boyce, Andrew K.J, Artamonov, Mykhaylo V, Askew-Page, Henry R, Keller, T.C Stevenson, Johnstone, Scott R, Weaver, Rachel B, Good, Miranda E, Murphy, Sara A, Best, Angela K, Mintz, Ellen L, Penuela, Silvia, Greenwood, Iain A, Machado, Roberto F, Somlyo, Avril V, Swayne, Leigh Anne, Minshall, Richard D, Isakson, Brant E

“…OBJECTIVE—Sympathetic nerve innervation of vascular smooth muscle cells (VSMCs) is a major regulator of arteriolar vasoconstriction, vascular resistance, and…”
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Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2) by Utepbergenov, Darkhan, Hennig, Paulina M, Derewenda, Urszula, Artamonov, Mykhaylo V, Somlyo, Avril V, Derewenda, Zygmunt S

“…Ribosomal S6 kinases (RSK) play important roles in cell signaling through the mitogen-activated protein kinase (MAPK) pathway. Each of the four RSK isoforms…”
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RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na + /H + exchanger by Artamonov, Mykhaylo V, Sonkusare, Swapnil K, Good, Miranda E, Momotani, Ko, Eto, Masumi, Isakson, Brant E, Le, Thu H, Cope, Eric L, Derewenda, Zygmunt S, Derewenda, Urszula, Somlyo, Avril V

“…Smooth muscle contraction is triggered when Ca /calmodulin-dependent myosin light chain kinase (MLCK) phosphorylates the regulatory light chain of myosin (RLC…”
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Molecular Mechanism of Telokin-mediated Disinhibition of Myosin Light Chain Phosphatase and cAMP/cGMP-induced Relaxation of Gastrointestinal Smooth Muscle by Khromov, Alexander S., Momotani, Ko, Jin, Li, Artamonov, Mykhaylo V., Shannon, John, Eto, Masumi, Somlyo, Avril V.

“…Phospho-telokin is a target of elevated cyclic nucleotide concentrations that lead to relaxation of gastrointestinal and some vascular smooth muscles (SM)…”
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Hemoglobin α/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction by Straub, Adam C, Butcher, Joshua T, Billaud, Marie, Mutchler, Stephanie M, Artamonov, Mykhaylo V, Nguyen, Anh T, Johnson, Tyler, Best, Angela K, Miller, Megan P, Palmer, Lisa A, Columbus, Linda, Somlyo, Avril V, Le, Thu H, Isakson, Brant E

“…OBJECTIVE—Hemoglobin α (Hb α) and endothelial nitric oxide synthase (eNOS) form a macromolecular complex at myoendothelial junctions; the functional role of…”
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On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF by Zheng, Meiying, Cierpicki, Tomasz, Momotani, Ko, Artamonov, Mykhaylo V, Derewenda, Urszula, Bushweller, John H, Somlyo, Avril V, Derewenda, Zygmunt S

“…The Dbl-family of guanine nucleotide exchange factors (GEFs) activate the cytosolic GTPases of the Rho family by enhancing the rate of exchange of GTP for GDP…”
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The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity by Zieba, Bartosz J., Artamonov, Mykhaylo V., Jin, Li, Momotani, Ko, Ho, Ruoya, Franke, Aaron S., Neppl, Ronald L., Stevenson, Andra S., Khromov, Alexander S., Chrzanowska-Wodnicka, Magdalena, Somlyo, Avril V.

“…Agonist activation of the small GTPase, RhoA, and its effector Rho kinase leads to down-regulation of smooth muscle (SM) myosin light chain phosphatase…”
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Rap1b in Smooth Muscle and Endothelium Is Required for Maintenance of Vascular Tone and Normal Blood Pressure by Lakshmikanthan, Sribalaji, Zieba, Bartosz J, Ge, Zhi-Dong, Momotani, Ko, Zheng, Xiaodong, Lund, Hayley, Artamonov, Mykhaylo V, Maas, Jason E, Szabo, Aniko, Zhang, David X, Auchampach, John A, Mattson, David L, Somlyo, Avril V, Chrzanowska-Wodnicka, Magdalena

“…OBJECTIVE—Small GTPase Ras-related protein 1 (Rap1b) controls several basic cellular phenomena, and its deletion in mice leads to several cardiovascular…”
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Signaling Pathways That Control Rho Kinase Activity Maintain the Embryonic Epicardial Progenitor State by Artamonov, Mykhaylo V., Jin, Li, Franke, Aaron S., Momotani, Ko, Ho, Ruoya, Dong, Xiu Rong, Majesky, Mark W., Somlyo, Avril V.

“…This study identifies signaling pathways that play key roles in the formation and maintenance of epicardial cells, a source of progenitors for coronary smooth…”
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Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study by Artamonov, Mykhaylo V, Momotani, Ko, Stevenson, Andra, Trentham, David R, Derewenda, Urszula, Derewenda, Zygmunt S, Read, Paul W, Gutkind, J Silvio, Somlyo, Avril V

“…Many agonists, acting through G-protein-coupled receptors and Gα subunits of the heterotrimeric G-proteins, induce contraction of smooth muscle through an…”
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Agonist-induced Ca2+ Sensitization in Smooth Muscle by Artamonov, Mykhaylo V., Momotani, Ko, Stevenson, Andra, Trentham, David R., Derewenda, Urszula, Derewenda, Zygmunt S., Read, Paul W., Gutkind, J. Silvio, Somlyo, Avril V.

“…Many agonists, acting through G-protein-coupled receptors and Gα subunits of the heterotrimeric G-proteins, induce contraction of smooth muscle through an…”
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p63RhoGEF Couples Gαq/11-Mediated Signaling to Ca2+ Sensitization of Vascular Smooth Muscle Contractility by Momotani, Ko, Artamonov, Mykhaylo V, Utepbergenov, Darkhan, Derewenda, Urszula, Derewenda, Zygmunt S, Somlyo, Avril V

“…RATIONALE:In normal and diseased vascular smooth muscle (SM), the RhoA pathway, which is activated by multiple agonists through G protein-coupled receptors…”
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p63RhoGEF Couples G αq/11 -Mediated Signaling to Ca 2+ Sensitization of Vascular Smooth Muscle Contractility by Momotani, Ko, Artamonov, Mykhaylo V., Utepbergenov, Darkhan, Derewenda, Urszula, Derewenda, Zygmunt S., Somlyo, Avril V.

“…Rationale: In normal and diseased vascular smooth muscle (SM), the RhoA pathway, which is activated by multiple agonists through G protein-coupled receptors…”
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The cAMP responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down regulation of RhoA activity by Zieba, Bartosz Jakub, Artamonov, Mykhaylo V, Jin, Li, Momotani, Ko, Ho, Ruoya, Franke, Aaron S, Neppl, Ronald L, Stevenson, Andra S, Khromov, Alexander S, Chrzanowska‐Wodnicka, Magdalena, Somlyo, Avril V

“…This study reports a new mechanism of cAMP mediated relaxation of Ca2+sensitized force, in smooth muscle (SM) through Epac, a GTP exchange factor for the small…”
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p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility by Momotani, Ko, Artamonov, Mykhaylo V, Utepbergenov, Darkhan, Derewenda, Urszula, Derewenda, Zygmunt S, Somlyo, Avril V

“…In normal and diseased vascular smooth muscle (SM), the RhoA pathway, which is activated by multiple agonists through G protein-coupled receptors (GPCRs),…”
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