Search Results - "Arshad, Tariq"

Lymphocyte Subset Counts in COVID‐19 Patients: A Meta‐Analysis by Huang, Wei, Berube, Julie, McNamara, Michelle, Saksena, Suraj, Hartman, Marsha, Arshad, Tariq, Bornheimer, Scott J., O'Gorman, Maurice

“…A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease…”
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Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling by Ahmed, Ahmed Abdullah, Chen, Shuang, Roman-Escorza, Maria, Angell, Richard, Oxenford, Sally, McConville, Matthew, Barton, Naomi, Sunose, Mihiro, Neidle, Dan, Haider, Shozeb, Arshad, Tariq, Neidle, Stephen

“…The tetrasubstituted naphthalene diimide compound QN-302 binds to G-quadruplex (G4) DNA structures. It shows high potency in pancreatic ductal adenocarcinoma…”
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The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer by Ahmed, Ahmed A, Greenhalf, William, Palmer, Daniel H, Williams, Nicole, Worthington, Jenny, Arshad, Tariq, Haider, Shozeb, Alexandrou, Effrosyni, Guneri, Dilek, Waller, Zoe A E, Neidle, Stephen

“…The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high…”
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A novel RAS inhibitor for pancreatic ductal adenocarcinoma by Arshad, Tariq

“…e16263 Background: Pancreatic cancer has a dismal survival rate and no good therapeutic options. Of all types of cancer, it is Pancreatic cancer that is most…”
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A novel pan-RAS inhibitor for malignant peripheral nerve sheath tumors by Arshad, Tariq

“…e23531 Background: Malignant Peripheral Nerve Sheath Tumors (MPNST) are a rare but deadly form of sarcoma originating from the Schwann cell compartment. They…”
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A novel pan-RAS inhibitor for luminal B breast cancer by Arshad, Tariq, Donninger, Howard, Burlison, Joe, Sabo, Mike, Trent, John, Clark, Geoffrey J.

“…e13132 Background: Luminal B breast cancer makes up between 10-20% of cases and is among the most lethal forms of breast cancer. Prognosis is little better…”
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Impact of novel pan-RAS inhibitors on efficacy and resistance to AMG-510 and MRTX-1133 in pancreatic cancer cell lines by Arshad, Tariq, Donninger, Howard, von Baby, Becca, Ferrill, Rachel, Burlison, Joe, Trent, John, Clark, Geoffrey J.

“…4155 Background: Mutant-activated RAS genes are the most frequently mutated gene family associated with cancer (almost 30% of all cancers contain a mutant RAS…”
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Abstract 576: The pan-quadruplex drug QN-302 selectively down-regulates key pathway targets in pancreatic cancer cells that are up-regulated in human pancreatic cancer by Neidle, Stephen, Ahmed, Ahmed A., Arshad, Tariq

“…Abstract We have previously disclosed (Ahmed et al, ACS Med Chem Lett, 2020) a novel small molecule G-quadruplex binding compound, QN-302, that is highly…”
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Abstract 3350: The pan-quadruplex drug QN-302 targets up-regulated genes in pancreatic cancer and in other cancer types and correlate with poor patient prognosis by Neidle, Stephen, Ahmed, Ahmed A., Arshad, Tariq

“…Abstract We have previously disclosed (Ahmed et al, ACS Med Chem Lett, 2020) a novel small molecule G-quadruplex binding compound, QN-302, that is highly…”
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Abstract A081: The pan-quadruplex experimental drug QN-302 in pancreatic ductal adenocarcinoma (PDAC): Potential biomarkers for clinical studies by Ahmed, Ahmed, Arshad, Tariq, Neidle, Stephen

“…Abstract Quadruplexes (G4s) are formed from G-rich elements widely prevalent in the human and other genomes. They comprise repetitive G-tracts of varying…”
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Abstract 390: A comparison of the activity of the quadruplex-targeting experimental drugs QN-302 and CX-5461 (pidnarulex) in wild-type and gemcitabine-resistant pancreatic cancer cell lines by Ahmed, Ahmed, Arshad, Tariq, Neidle, Stephen

“…Abstract The compound QN-302, a tetra-substituted naphthalene diimide (ND) derivative has been designed as a potent compound for targeting quadruplex sequences…”
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Abstract A079: The quadruplex-binding compound QN-302 in the MIA-PaCa2 pancreatic adenocarcinoma model shows no evidence of cardiac or neurological liabilities at therapeutic doses by Ahmed, Ahmed, Arshad, Tariq, Neidle, Stephen

“…Abstract The human genome contains multiple sites of quadruplex (G4) arrangements, with over-representation in promoter regions of many oncogenes. Small…”
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Abstract CT105: Early clinical experience with a novel first-in-class G-quadruplex experimental anti-cancer drug by Arshad, Tariq, Neidle, Stephen, Chandana, Sreenivasa, Borazanci, Erkut

“…Abstract The human genome contains G-rich regions that are over-represented in many cancer gene promoters. These can form higher-order G-quadruplex…”
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Abstract 5928: Structure-activity relationships for the pan-quadruplex experimental drug QN-302 and two analogs probed with comparative transcriptome profiling and molecular modeling by Ahmed, Ahmed A., Haider, Shozeb, Arshad, Tariq, Neidle, Stephen

“…Abstract The tetrasubstituted naphthalene diimide compound QN-302 binds to G-quadruplex DNA structures. It inhibits the transcription of cancer-related genes…”
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Abstract 4981: The potent quadruplex-binding compound QN-302 down-regulates the S100P gene in in vitro and in vivo models of pancreatic cancer: a potential therapeutic target and biomarker for PDAC by Williams, Nicole, Worthington, Jenny, Ahmed, Ahmed, Arshad, Tariq, Neidle, Stephen

“…Abstract The compound QN-302, a tetra-substituted naphthalene diimide (ND) derivative has been designed to have high affinity for G-quadruplex (G4) nucleic…”
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Abstract B030: The quadruplex-binding compound QN-302 targets the S100P gene in PDAC by Ahmed, Ahmed, Greenhalf, William, Arshad, Tariq, Neidle, Stephen S.

“…Abstract The compound QN-302, a tetra-substituted naphthalene diimide derivative has been previously disclosed to have single-digit nM anti-proliferative…”
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Abstract 3320: In vivo and in vitro experience with novel direct Pan-RAS inhibitors by Arshad, Tariq, Donninger, Howard, Clarke, Goeff, Burlison, Joe, Monsen, Rob, Sabo, Mike

“…Abstract RAS oncogenes are frequently activated by mutations in human cancer, where they act as driving elements of the disease. Mutation rates can range from…”
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Abstract B020: Pan-RAS inhibitors to treat luminal B beast cancer by Clark, Geoff, Jigo, Raphael, Donninger, Howard, Burlison, Joe, Sabo, Mike, Arshad, tariq, Trent, John

“…Abstract The RAS oncoprotein has not traditionally been considered as an important driver of breast cancer due to the paucity of RAS mutations in this disease…”
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Abstract A080: Target genes in pancreatic cancer cells of the pan-quadruplex clinical candidate compound QN-302 revealed by comparative transcriptome profiling by Ahmed, Ahmed, Arshad, Tariq, Roman-Escorza, Maria, Neidle, Dan M., Neidle, Stephen

“…Abstract QN-302 is a tetra-substituted naphthalene derivative designed to have high affinity to quadruplexes in cancer-related genes, which have multiple…”
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Abstract 6240: The potent quadruplex-binding compound QN-302 shows anti-tumor activity as a monotherapy in an orthotopic in vivo model of pancreatic cancer by Williams, Nicole, Santos, Danielle, Worthington, Jenny, Ahmed, Ahmed, Arshad, Tariq, Neidle, Stephen

“…Abstract The compound QN-302, a tetra-substituted naphthalene diimide derivative has single-digit nM anti-proliferative activity in a panel of human pancreatic…”
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