Search Results - "Arruri, Vijay"

Probucol attenuates NF-κB/NLRP3 signalling and augments Nrf-2 mediated antioxidant defence in nerve injury induced neuropathic pain by Derangula, Kalyani, Javalgekar, Mohit, kumar Arruri, Vijay, Gundu, Chayanika, kumar Kalvala, Anil, kumar, Ashutosh

“…•CCI of sciatic nerve resulted in long-lasting hyperalgesia and allodynia in rats.•Unregulated activation of NF-κB/Nlrp3 inflammasome contributed to CCI…”
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LONG NONCODING RNA INTERACTION IS ESSENTIAL FOR EPIGENETIC MODULATION OF ISCHEMIC BRAIN DAMAGE by Vemuganti, Raghu, Arruri, Vijay, Morris-Blanco, Kahlilia

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CDR1as regulates α-synuclein-mediated ischemic brain damage by controlling miR-7 availability by Mehta, Suresh L., Chokkalla, Anil K., Bathula, Saivenkateshkomal, Arruri, Vijay, Chelluboina, Bharath, Vemuganti, Raghu

“…Transient focal ischemia decreased microRNA-7 (miR-7) levels, leading to derepression of its major target α-synuclein (α-Syn) that promotes secondary brain…”
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GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells by Gundu, Chayanika, Arruri, Vijay Kumar, Sherkhane, Bhoomika, Khatri, Dharmendra Kumar, Singh, Shashi Bala

“…Neuronal dysfunction and subsequent apoptosis under high glucose conditions during diabetes contribute majorly to the manifestation of diabetic peripheral…”
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Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking by Gundu, Chayanika, Arruri, Vijay Kumar, Yadav, Poonam, Navik, Umashanker, Kumar, Ashutosh, Amalkar, Veda Sudhir, Vikram, Ajit, Gaddam, Ravinder Reddy

“…Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory…”
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Role of autophagy and transcriptome regulation in acute brain injury by Arruri, Vijay, Vemuganti, Raghu

“…Autophagy is an evolutionarily conserved intracellular system that routes distinct cytoplasmic cargo to lysosomes for degradation and recycling. Accumulating…”
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Role of transcription factors, noncoding RNAs, epitranscriptomics, and epigenetics in post‐ischemic neuroinflammation by Mehta, Suresh L., Arruri, Vijay, Vemuganti, Raghu

“…Post‐stroke neuroinflammation is pivotal in brain repair, yet persistent inflammation can aggravate ischemic brain damage and hamper recovery. Following…”
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Non-pharmacological interventions for traumatic brain injury by Davis, Charles K, Arruri, Vijay, Joshi, Pallavi, Vemuganti, Raghu

“…Heterogeneity and variability of symptoms due to the type, site, age, sex, and severity of injury make each case of traumatic brain injury (TBI) unique…”
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Abstract WP314: Post-Stroke Regulation of α-Synuclein by microRNA miR-7 and Circular RNA CDR1as by Vemuganti, Raghu, Mehta, Suresh L, Arruri, Vijay K, Chokkalla, Anil K, Bathula, Saivenkateshkomal, Chelluboina, Bharath

“…Abstract only α-Synuclein (α-Syn) induced after stroke is a known mediator of ischemic brain damage. We currently evaluated the molecular mechanisms that…”
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Carvacrol abates NLRP3 inflammasome activation by augmenting Keap1/Nrf-2/p62 directed autophagy and mitochondrial quality control in neuropathic pain by Arruri, Vijay Kumar, Gundu, Chayanika, Kalvala, Anil Kumar, Sherkhane, Bhoomika, Khatri, Dharmendra Kumar, Singh, Shashi Bala

“…Objectives: We aimed to evaluate the effect of carvacrol (CRC), a phenolic monoterpene with high nutritional value on NLRP3 activation against chronic…”
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Indole-3-propionic acid attenuates high glucose induced ER stress response and augments mitochondrial function by modulating PERK-IRE1-ATF4-CHOP signalling in experimental diabetic neuropathy by Gundu, Chayanika, Arruri, Vijay Kumar, Sherkhane, Bhoomika, Khatri, Dharmendra Kumar, Singh, Shashi Bala

“…We aimed to evaluate the neuroprotective effect of Indole-3-propionic acid (IPA) against streptozotocin (STZ) induced diabetic peripheral neuropathy (DPN) in…”
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Melatonin prevents diabetes‐induced nephropathy by modulating the AMPK/SIRT1 axis: Focus on autophagy and mitochondrial dysfunction by Siddhi, Jain, Sherkhane, Bhoomika, Kalavala, Anil Kumar, Arruri, Vijay, Velayutham, Ravichandiran, Kumar, Ashutosh

“…Impaired nutrient sensing mechanisms such as AMPK/silent information regulator type 1 (SIRT1) axis and autophagy in renal cells upon chronic diabetic condition…”
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Exploring the role of miRNA in diabetic neuropathy: from diagnostics to therapeutics by Saha, Priya, Yarra, Sai Sumanjali, Arruri, Vijay, Mohan, Utpal, Kumar, Ashutosh

“…Diabetic neuropathy (DN) is one of the major microvascular complications of diabetes mellitus affecting 50% of the diabetic population marred by various unmet…”
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Bardoxolone Methyl Ameliorates Hyperglycemia Induced Mitochondrial Dysfunction by Activating the keap1-Nrf2-ARE Pathway in Experimental Diabetic Neuropathy by Kalvala, Anil Kumar, Kumar, Rahul, Sherkhane, Bhoomika, Gundu, Chayanika, Arruri, Vijay Kumar, Kumar, Ashutosh

“…Bardoxolone methyl (Bard), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator regulates multiple oxidative and inflammatory diseases. However, the…”
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Abstract WP236: Tet3 Overexpression Improves Functional Recovery In Male And Female Mice Following Focal Ischemia by Probelsky, Samantha M, Gaillard, Alexis B, Jeong, Soomin, Davis, Charles K, Arruri, Vijay, Vemuganti, Raghu, Morris-Blanco, Kahlilia C

“…Epigenetic mechanisms have been shown to play a major role in the progression of stroke pathophysiology. The ten eleven translocases (TETs) are enzymes…”
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FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats by Komirishetty, Prashanth, Areti, Aparna, Arruri, Vijay Kumar, Sistla, Ramakrishna, Gogoi, Ranadeep, Kumar, Ashutosh

“…Neuropathic pain is a maladaptive pain phenotype that results from injury or damage to the somatosensory nervous system and is proposed to be linked to a…”
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Epigenetic mechanisms and potential therapeutic targets in stroke by Morris-Blanco, Kahlilia C, Chokkalla, Anil K, Arruri, Vijay, Jeong, Soomin, Probelsky, Samantha M, Vemuganti, Raghu

“…Accumulating evidence indicates a central role for epigenetic modifications in the progression of stroke pathology. These epigenetic mechanisms are involved in…”
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An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice by Davis, Charles K., Bathula, Saivenkateshkomal, Jeong, Soomin, Arruri, Vijay, Choi, Jeongwoo, Subramanian, Shruti, Ostrom, Carlie M., Vemuganti, Raghu

“…Clinical studies have shown that traumatic brain injury (TBI) increases the onset of Parkinson's disease (PD) in later life by >50%. Oxidative stress,…”
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Nrf2 and NF-κB modulation by Plumbagin attenuates functional, behavioural and biochemical deficits in rat model of neuropathic pain by Arruri, Vijay, Komirishetty, Prashanth, Areti, Aparna, Dungavath, Siva Kumar Naik, Kumar, Ashutosh

“…Plumbagin is known to exhibit a broad range of biological activities including anti-cancer, antimicrobial and has been widely used traditionally. Nuclear…”
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Loss of Epitranscriptomic Modification N 6 -Methyladenosine (m 6 A) Reader YTHDF1 Exacerbates Ischemic Brain Injury in a Sexually Dimorphic Manner by Chokkalla, Anil K, Arruri, Vijay, Mehta, Suresh L, Vemuganti, Raghu

“…N -Methyladenosine (m A) is a neuronal-enriched, reversible post-transcriptional modification that regulates RNA metabolism. The m A-modified RNAs recruit…”
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