Search Results - "Arris, Christine E"

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor by Newell, David R, Davies, Thomas G, Bentley, Johanne, Arris, Christine E, Boyle, F. Thomas, Curtin, Nicola J, Endicott, Jane A, Gibson, Ashleigh E, Golding, Bernard T, Griffin, Roger J, Hardcastle, Ian R, Jewsbury, Philip, Johnson, Louise N, Mesguiche, Veronique, Noble, Martin E.M, Tucker, Julie A, Wang, Lan, Whitfield, Hayley J

“…Aberrant control of cyclin-dependent kinases (CDKs) is a central feature of the molecular pathology of cancer. Iterative structure-based design was used to…”
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Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles by Arris, Christine E, Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J, Endicott, Jane A, Garman, Elspeth F, Gibson, Ashleigh E, Golding, Bernard T, Grant, Sharon, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Lawrie, Alison M, Newell, David R, Noble, Martin E. M, Sausville, Edward A, Schultz, Robert, Yu, Wyatt

“…Substituted guanines and pyrimidines were tested as inhibitors of cyclin B1/CDK1 and cyclin A3/CDK2 and soaked into crystals of monomeric CDK2. O…”
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Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives by Gibson, Ashleigh E, Arris, Christine E, Bentley, Johanne, Boyle, F Thomas, Curtin, Nicola J, Davies, Thomas G, Endicott, Jane A, Golding, Bernard T, Grant, Sharon, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Mesguiche, Veronique, Newell, David R, Noble, Martin E M, Tucker, Julie A, Whitfield, Hayley J

“…O(6)-substituted guanines are adenosine 5'-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the…”
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Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O6-Substituted Guanine Derivatives by GIBSON, Ashleigh E., ARRIS, Christine E., BENTLEY, Johanne, BOYLE, F. Thomas, CURTIN, Nicola J., DAVIES, Thomas G., ENDICOTT, Jane A., GOLDING, Bernard T., GRANT, Sharon, GRIFFIN, Roger J., JEWSBURY, Philip, JOHNSON, Louise N., MESGUICHE, Veronique, NEWELL, David R., NOBLE, Martin E. M., TUCKER, Julie A., WHITFIELD, Hayley J.

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4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2 by Mesguiche, Veronique, Parsons, Rachel J, Arris, Christine E, Bentley, Johanne, Boyle, F.Thomas, Curtin, Nicola J, Davies, Thomas G, Endicott, Jane A, Gibson, Ashleigh E, Golding, Bernard T, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Newell, David R, Noble, Martin E.M, Wang, Lan Z, Hardcastle, Ian R

“…The cyclin dependent kinase (cdk) inhibitor NU6027, 4-cyclohexylmethoxy-5-nitroso-pyrimidine-2,6-diamine (IC 50 vs cdk1/cyclinB1=2.9±0.1 μM and IC 50 vs…”
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Resistance-Modifying Agents. 8. Inhibition of O 6-Alkylguanine-DNA Alkyltransferase by O 6-Alkenyl-, O 6-Cycloalkenyl-, and O 6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O 6-(1-Cyclopentenylmethyl)guanine by Griffin, Roger J, Arris, Christine E, Bleasdale, Christine, Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J, Dalby, Christine, Kanugula, Sreenivas, Lembicz, Nicola K, Newell, David R, Pegg, Anthony E, Golding, Bernard T

“…A series of O 6-allyl- and O 6-(2-oxoalkyl)guanines were synthesized and evaluated, in comparison with the corresponding O 6-alkylguanines, as potential…”
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DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767 by Monks, Noel R., Blakey, David C., East, Simon J., Dowell, Robert I., Calvete, Joanne A., Curtin, Nicola J., Arris, Christine E., Newell, David R.

“…Cellular determinants of sensitivity to the bifunctional alkylating agent 4-[ N, N-bis(2-iodoethyl)amino]phenol (ZD2767D), the active drug produced by ZD2767…”
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Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients by Arris, Christine E., Bevitt, Debra J., Mohamed, Jeseem, Li, Zheng, Langton, Kevin P., Barker, Michael D., Clarke, Michael P., McKie, Norman

“…Gingival fibroblast cell lines were derived from Sorsby's fundus dystrophy (SFD) patients carrying the S181C TIMP3 and the E139X TIMP3 mutations. These cell…”
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N2-Substituted O6-Cyclohexylmethylguanine Derivatives:  Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 by HARDCASTLE, Ian R., ARRIS, Christine E., BENTLEY, Johanne, BOYLE, F. Thomas, CHEN, Yuzhu, CURTIN, Nicola J., ENDICOTT, Jane A., GIBSON, Ashleigh E., GOLDING, Bernard T., GRIFFIN, Roger J., JEWSBURY, Philip, MENYEROL, Jerome, MESGUICHE, Veronique, NEWELL, David R., NOBLE, Martin E. M., PRATT, David J., WANG, Lan-Zhen, WHITFIELD, Hayley J.

“…The adenosine 5'-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a…”
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Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O 6-Substituted Guanine Derivatives by Gibson, Ashleigh E, Arris, Christine E, Bentley, Johanne, Boyle, F. Thomas, Curtin, Nicola J, Davies, Thomas G, Endicott, Jane A, Golding, Bernard T, Grant, Sharon, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Mesguiche, Veronique, Newell, David R, Noble, Martin E. M, Tucker, Julie A, Whitfield, Hayley J

“…O 6-Substituted guanines are adenosine 5‘-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O 6 substituent occupying the…”
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Resistance-Modifying Agents. 8. Inhibition of O6-Alkylguanine-DNA Alkyltransferase by O6-Alkenyl-, O6-Cycloalkenyl-, and O6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O6-(1-Cyclopentenylmethyl)guanine by GRIFFIN, Roger J., ARRIS, Christine E., BLEASDALE, Christine, BOYLE, F. Thomas, CALVERT, A. Hilary, CURTIN, Nicola J., DALBY, Christine, KANUGULA, Sreenivas, LEMBICZ, Nicola K., NEWELL, David R., PEGG, Anthony E., GOLDING, Bernard T.

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N 2 -Substituted O 6 -Cyclohexylmethylguanine Derivatives:  Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 by Hardcastle, Ian R., Arris, Christine E., Bentley, Johanne, Boyle, F. Thomas, Chen, Yuzhu, Curtin, Nicola J., Endicott, Jane A., Gibson, Ashleigh E., Golding, Bernard T., Griffin, Roger J., Jewsbury, Philip, Menyerol, Jerome, Mesguiche, Veronique, Newell, David R., Noble, Martin E. M., Pratt, David J., Wang, Lan-Zhen, Whitfield, Hayley J.

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Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha by Bevitt, Debra J, Mohamed, Jeseem, Catterall, Jon B, Li, Zheng, Arris, Christine E, Hiscott, Paul, Sheridan, Carl, Langton, Kevin P, Barker, Michael D, Clarke, Michael P, McKie, Norman

“…ADAMTS (A Disintegrin-like And Metalloprotease domain with ThromboSpondin type I motifs) are multidomain proteins with demonstrated metalloproteinase…”
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N2-Substituted O 6-Cyclohexylmethylguanine Derivatives:  Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 by Hardcastle, Ian R, Arris, Christine E, Bentley, Johanne, Boyle, F. Thomas, Chen, Yuzhu, Curtin, Nicola J, Endicott, Jane A, Gibson, Ashleigh E, Golding, Bernard T, Griffin, Roger J, Jewsbury, Philip, Menyerol, Jerome, Mesguiche, Veronique, Newell, David R, Noble, Martin E. M, Pratt, David J, Wang, Lan-Zhen, Whitfield, Hayley J

“…The adenosine 5‘-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O 6-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a…”
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Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFα by Bevitt, Debra J., Mohamed, Jeseem, Catterall, Jon B., Li, Zheng, Arris, Christine E., Hiscott, Paul, Sheridan, Carl, Langton, Kevin P., Barker, Michael D., Clarke, Michael P., McKie, Norman

“…ADAMTS (A Disintegrin-like And Metalloprotease domain with ThromboSpondin type I motifs) are multidomain proteins with demonstrated metalloproteinase…”
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