Search Results - "Arrighetti, Noemi"

Bio-inspired engineering of cell- and virus-like nanoparticles for drug delivery by Parodi, Alessandro, Molinaro, Roberto, Sushnitha, Manuela, Evangelopoulos, Michael, Martinez, Jonathan O., Arrighetti, Noemi, Corbo, Claudia, Tasciotti, Ennio

“…The engineering of future generations of nanodelivery systems aims at the creation of multifunctional vectors endowed with improved circulation, enhanced…”
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Exosome-like Nanovectors for Drug Delivery in Cancer by Arrighetti, Noemi, Corbo, Claudia, Evangelopoulos, Michael, Pastò, Anna, Zuco, Valentina, Tasciotti, Ennio

“…Cancer treatment still represents a formidable challenge, despite substantial advancements in available therapies being made over the past decade. One major…”
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miRNAs as Therapeutic Tools and Biomarkers for Prostate Cancer by Arrighetti, Noemi, Beretta, Giovanni Luca

“…Prostate cancer (PCa) is the fifth cause of tumor-related deaths in man worldwide. Despite the considerable improvement in the clinical management of PCa,…”
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miR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis by El Bezawy, Rihan, Cominetti, Denis, Fenderico, Nicola, Zuco, Valentina, Beretta, Giovanni Luca, Dugo, Matteo, Arrighetti, Noemi, Stucchi, Claudio, Rancati, Tiziana, Valdagni, Riccardo, Zaffaroni, Nadia, Gandellini, Paolo

“…Abstract Radiotherapy is one of the main treatment choices for non-metastatic prostate cancer (PCa), although development of radioresistance limits its…”
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Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma by Lanzi, Cinzia, Favini, Enrica, Dal Bo, Laura, Tortoreto, Monica, Arrighetti, Noemi, Zaffaroni, Nadia, Cassinelli, Giuliana

“…Synovial sarcoma (SS) is an aggressive soft tissue tumor with limited therapeutic options in advanced stage. SS18-SSX fusion oncogenes, which are the hallmarks…”
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Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells by Cossa, Giacomo, Lanzi, Cinzia, Cassinelli, Giuliana, Carenini, Nives, Arrighetti, Noemi, Gatti, Laura, Corna, Elisabetta, Zunino, Franco, Zaffaroni, Nadia, Perego, Paola

“…Abstract Deregulated pro-survival signalling plays a role in ovarian carcinoma drug resistance. Here, we show that cisplatin or oxaliplatin in combination with…”
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Overactive IGF1/Insulin Receptors and NRASQ61R Mutation Drive Mechanisms of Resistance to Pazopanib and Define Rational Combination Strategies to Treat Synovial Sarcoma by Lanzi, Cinzia, Dal Bo, Laura, Favini, Enrica, Tortoreto, Monica, Beretta, Giovanni Luca, Arrighetti, Noemi, Zaffaroni, Nadia, Cassinelli, Giuliana

“…Pazopanib is approved for treatment of advanced soft tissue sarcomas, but primary and secondary drug resistance limits its clinical utility. We investigated…”
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Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt by Vetro, Maria, Costa, Barbara, Donvito, Giulia, Arrighetti, Noemi, Cipolla, Laura, Perego, Paola, Compostella, Federica, Ronchetti, Fiamma, Colombo, Diego

“…New glucuronosyldiacylglycerol (GlcADG) analogues based on a 2-O-β-D-glucopyranosyl-sn-glycerol scaffold and carrying one or two acyl chains of different…”
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Synergistic Interaction of Histone Deacetylase 6- and MEK-Inhibitors in Castration-Resistant Prostate Cancer Cells by Corno, Cristina, Arrighetti, Noemi, Ciusani, Emilio, Corna, Elisabetta, Carenini, Nives, Zaffaroni, Nadia, Gatti, Laura, Perego, Paola

“…In spite of new knowledge on prostate cancer molecular landscape, this has been only partially translated to the therapeutic setting. The activation of…”
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The deubiquitinase USP8 regulates ovarian cancer cell response to cisplatin by suppressing apoptosis by Corno, Cristina, D'Arcy, Padraig, Bagnoli, Marina, Paolini, Biagio, Costantino, Matteo, Carenini, Nives, Corna, Elisabetta, Alberti, Paola, Mezzanzanica, Delia, Colombo, Diego, Linder, Stig, Arrighetti, Noemi, Perego, Paola

“…The identification of therapeutic approaches to improve response to platinum-based therapies is an urgent need for ovarian carcinoma. Deubiquitinases are a…”
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Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals by Gatti, Laura, Sevko, Alexandra, De Cesare, Michelandrea, Arrighetti, Noemi, Manenti, Giacomo, Ciusani, Emilio, Verderio, Paolo, Ciniselli, Chiara M, Cominetti, Denis, Carenini, Nives, Corna, Elisabetta, Zaffaroni, Nadia, Rodolfo, Monica, Rivoltini, Licia, Umansky, Viktor, Perego, Paola

“…Target-specific agents used in melanoma are not curative, and chemokines are being implicated in drug-resistance to target-specific agents. Thus, the use of…”
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Targeting EZH2 in SMARCB1-deficient sarcomas: Advances and opportunities to potentiate the efficacy of EZH2 inhibitors by Lanzi, Cinzia, Arrighetti, Noemi, Pasquali, Sandro, Cassinelli, Giuliana

“…[Display omitted] Soft tissue sarcomas (STSs) are rare mesechymal malignancies characterized by distintive molecular, histological and clinical features. Many…”
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Axl molecular targeting counteracts aggressiveness but not platinum-resistance of ovarian carcinoma cells by Corno, Cristina, Gatti, Laura, Arrighetti, Noemi, Carenini, Nives, Zaffaroni, Nadia, Lanzi, Cinzia, Perego, Paola

“…[Display omitted] Ovarian carcinoma, the most common gynaecological cancer, is characterized by high lethality mainly due to late diagnosis and treatment…”
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Leukocyte-mimicking nanovesicles for effective doxorubicin delivery to treat breast cancer and melanoma by Molinaro, Roberto, Martinez, Jonathan O, Zinger, Assaf, De Vita, Alessandro, Storci, Gianluca, Arrighetti, Noemi, De Rosa, Enrica, Hartman, Kelly A, Basu, Nupur, Taghipour, Nima, Corbo, Claudia, Tasciotti, Ennio

“…In the last decades, several approaches were developed to design drug delivery systems to address the multiple biological barriers encountered after…”
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PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells by Arrighetti, Noemi, Cossa, Giacomo, De Cecco, Loris, Stucchi, Simone, Carenini, Nives, Corna, Elisabetta, Gandellini, Paolo, Zaffaroni, Nadia, Perego, Paola, Gatti, Laura

“…The occurrence of drug resistance limits the efficacy of platinum compounds in the cure of ovarian carcinoma. Since microRNAs (miRNAs) may contribute to this…”
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Drug Combinations with HDAC Inhibitors in Antitumor Therapy by Arrighetti, Noemi, Corno, Cristina, Gatti, Laura

“…The treatment of tumor cells with HDAC inhibitors (HDACi) induces a range of effects including apoptosis, cell cycle arrest, differentiation and senescence,…”
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Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells by Colombo, Diego, Gatti, Laura, Sjöstrand, Linda, Carenini, Nives, Costantino, Matteo, Corna, Elisabetta, Arrighetti, Noemi, Zuccolo, Marco, De Cesare, Michelandrea, Linder, Stig, D'Arcy, Pádraig, Perego, Paola

“…[Display omitted] Deubiquitinases (DUBs) mediate the removal of ubiquitin from diverse proteins that participate in the regulation of cell survival, DNA damage…”
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Endosomal Escape of Polymer‐Coated Silica Nanoparticles in Endothelial Cells by Parodi, Alessandro, Evangelopoulos, Michael, Arrighetti, Noemi, Cevenini, Armando, Livingston, Megan, Khaled, Sm Z., Brown, Brandon S., Yazdi, Iman K., Paradiso, Francesca, Campa‐Carranza, Jocelyn N., De Vita, Alessandro, Taraballi, Francesca, Tasciotti, Ennio

“…Current investigations into hazardous nanoparticles (i.e., nanotoxicology) aim to understand the working mechanisms that drive toxicity. This understanding has…”
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Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy by Kazansky, Yaniv, Cameron, Daniel, Mueller, Helen S, Demarest, Phillip, Zaffaroni, Nadia, Arrighetti, Noemi, Zuco, Valentina, Kuwahara, Yasumichi, Somwar, Romel, Ladanyi, Marc, Qu, Rui, de Stanchina, Elisa, Dela Cruz, Filemon S, Kung, Andrew L, Gounder, Mrinal M, Kentsis, Alex

“…Epigenetic dependencies have become evident in many cancers. On the basis of antagonism between BAF/SWI-SNF and PRC2 in SMARCB1-deficient sarcomas, we recently…”
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RNA interference approaches and assessment of new delivery systems to target heparanase in soft tissue sarcomas by Arrighetti, Noemi

“…Soft tissue sarcomas are rare tumours of mesenchymal origin characterised by high biomolecular complexity and heterogeneity. The clinical management of…”
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