Search Results - "Arrate, Maria P."

TLR3 agonism augments CD47 inhibition in acute myeloid leukemia by Ramsey, Haley E, Gorska, Agnieszka E, Smith, Brianna N, Monteith, Andrew J, Fuller, Londa, Arrate, Maria P, Savona, Michael R

“…CD47-SIRPa is a myeloid check point pathway that promotes phagocytosis of cells lacking markers for self-recognition. Tumor cells can overexpress CD47 and bind…”
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Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia by Cojocari, Dan, Smith, Brianna N, Purkal, Julie J, Arrate, Maria P, Huska, Jason D, Xiao, Yu, Gorska, Agnieszka, Hogdal, Leah J, Ramsey, Haley E, Boghaert, Erwin R, Phillips, Darren C, Savona, Michael R

“…Dysregulation of apoptotic machinery is one mechanism by which acute myeloid leukemia (AML) acquires a clonal survival advantage. B-cell lymphoma protein-2…”
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BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia by Ramsey, Haley E, Greenwood, Dalton, Zhang, Susu, Childress, Merrida, Arrate, Maria P, Gorska, Agnieszka E, Fuller, Londa, Zhao, Yue, Stengel, Kristy, Fischer, Melissa A, Stubbs, Matthew C, Liu, Phillip C C, Boyd, Kelli, Rathmell, Jeffrey C, Hiebert, Scott W, Savona, Michael R

“…The BCL2 inhibitor, venetoclax, has transformed clinical care in acute myeloid leukemia (AML). However, subsets of patients do not respond or eventually…”
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Selective inhibition of MCL1 overcomes venetoclax resistance in a murine model of myelodysplastic syndromes by Fischer, Melissa A, Song, Yuanbin, Arrate, Maria P, Gbyli, Rana, Villaume, Matthew T, Smith, Brianna N, Childress, Merrida A, Stricker, Thomas P, Halene, Stephanie, Savona, Michael R

“…Treatment for myelodysplastic syndromes (MDS) remains insufficient due to clonal heterogeneity and lack of effective clinical therapies. Dysregulation of…”
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Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia by Monteith, Andrew J, Ramsey, Haley E, Silver, Alexander J, Brown, Donovan, Greenwood, Dalton, Smith, Brianna N, Wise, Ashley D, Liu, Juan, Olmstead, Sarah D, Watke, Jackson, Arrate, Maria P, Gorska, Agnieszka E, Fuller, Londa, Locasale, Jason W, Stubbs, Matthew C, Rathmell, Jeffrey C, Savona, Michael R

“…Impairing the BET family coactivator BRD4 with small-molecule inhibitors (BETi) showed encouraging preclinical activity in treating acute myeloid leukemia…”
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Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies by Fischer, Melissa A., Friedlander, Sharon Y., Arrate, Maria P., Chang, Hua, Gorska, Agnieszka E., Fuller, Londa D., Ramsey, Haley E., Kashyap, Trinayan, Argueta, Christian, Debler, Sophie, Byrne, Michael, Villaume, Matthew T., Shaver, Aaron C., Senapedis, William, Landesman, Yosef, Baloglu, Erkan, Shacham, Sharon, Savona, Michael R.

“…The selective inhibitor of nuclear export (SINE) compounds selinexor (KPT-330) and eltanexor (KPT-8602) are from a novel class of small molecules that target…”
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Electron Transport Chain Complex V Inhibition Enhances the Antileukemic Activity of Low-Dose Venetoclax in Acute Myeloid Leukemia by Ramsey, Haley E., Reisman, Benjamin J., Arrate, Maria P., Gorska, Agnieszka E., Fuller, Londa, Bachmann, Brian O., Savona, Michael R.

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Lactate Utilization Provides a Metabolic Escape to Resist the Antileukemic Activity of BET Inhibition in Acute Myeloid Leukemia by Monteith, Andrew J., Ramsey, Haley E., Greenwood, Dalton, Arrate, Maria P., Fuller, Londa, Gorska, Agnieszka E., Silver, Alexander J., Brown, Donovan J., Olmstead, Sarah D., Watke, Jackson, Stubbs, Matthew J., Rathmell, Jeffrey C., Savona, Michael R.

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Primary HSPC-Derived Monocytes with DNMT3A p.R882H Exhibit Activated Myeloid Cell Gene Signatures by Silver, Alexander J., Brown, Donovan J., Arrate, Maria P., Wang, Yu, Fischer, Melissa A., Bhat, Pawan, Heimlich, J. Brett, Bick, Alexander G., Ferrell, P. Brent, Xu, Yaomin, Savona, Michael R.

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DNMT3A R882H Exhibits Greater Inflammatory Potential Than R882C in Primary Hematopoietic Stem and Progenitor Cell Knock-in Model and Population Data by Silver, Alexander J, Brown, Donovan J, Vlasschaert, Caitlyn, Bhat, Pawan, Puddu, Fabio, Van Amburg, Joseph C, Villaume, Matthew T, Fischer, Melissa A, Arrate, Maria P, Wang, Yu, Scotcher, Jamie, Stengel, Kristy, Smith, Brianna Nicole, Sharber, Brian, Potts, Chad R, Consugar, Mark, Heimlich, Jonathan Brett, Xu, Yaomin, Ferrell, P. Brent, Bick, Alexander G., Savona, Michael R.

“…Clonal hematopoiesis (CH) is an age-associated phenomenon which is known to increase the risk for hematologic malignancy and cardiovascular disease. The most…”
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Abstract LB-168: MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer by Edmonds, Mick D., Boyd, Kelli L., Moyo, Tamara K., Mitra, Ramkrishna, Duszynski, Robert J., Arrate, Maria P., Chen, Xi, Zhao, Zhongming, Blackwell, Timothy S., Eischen, Christine M.

“…Abstract Lung cancer is the leading cause of cancer deaths and yet the genes that drive this malignancy are not entirely known. MicroRNA (miRNA) are important…”
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Abstract 1768: The oncogene Mdmx promotes genomic instability independent of p53 by Melo, Alexia N., Bouska, Alyssa, Arrate, Maria P., Eischen, Christine M.

“…Abstract Mdmx is upregulated in many human cancers. As a member of the Mdm2 protein family, Mdmx functions similar to Mdm2 as a negative regulator of the tumor…”
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