Search Results - "Arranz, M J"

Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research by ARRANZ, M. J, DE LEON, J

“…The last decade of research into the pharmacogenetics of antipsychotics has seen the development of genetic tests to determine the patients' metabolic status…”
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Pharmacogenetic prediction of clozapine response by Arranz, MJ, Munro, J, Birkett, J, Bolonna, A, Mancama, D, Sodhi, M, Lesch, KP, Meyer, JFW, Sham, P, Collier, DA, Murray, RM, Kerwin, RW

“…We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in…”
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Reduced expression of the muscarinic 1 receptor cortical subtype in schizophrenia by Mancama, D., Arranz, MJ, Landau, S., Kerwin, R.

“…The involvement of specific pathways mediated through muscarinic receptor activity has been widely implicated in schizophrenia. Extensive pharmacological…”
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Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant by Hwang, R, Zai, C, Tiwari, A, Müller, D J, Arranz, M J, Morris, A G, McKenna, P J, Munro, J, Potkin, S G, Lieberman, J A, Meltzer, H Y, Kennedy, J L

“…D2 blockade has been implicated in having a central role in antipsychotic response. However, treatment refractoriness, in spite of complete D2 blockade, as…”
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Inflammatory and immune response genes have significantly altered expression in schizophrenia by Sainz, J, Mata, I, Barrera, J, Perez-Iglesias, R, Varela, I, Arranz, M J, Rodriguez, M C, Crespo-Facorro, B

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Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder by MUNDO, E, THARMALINGHAM, S, KENNEDY, J. L, NEVES-PEREIRA, M, DALTON, E. J, MACCIARDI, F, PARIKH, S. V, BOLONN, A, KERWIN, R. W, ARRANZ, M. J, MAKOFF, A. J

“…There is evidence for the involvement of glutamatergic transmission in the pathogenesis of major psychoses. The two most commonly used mood stabilizers (ie…”
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Association between neonatal temperament, SLC6A4, DRD4 and a functional polymorphism located in TFAP2B by Ivorra, J. L., D'Souza, U. M., Jover, M., Arranz, M. J., Williams, B. P., Henry, S. E., Sanjuan, J., Molto, M. D.

“…Genetic studies on human personality have provided little satisfactory results to date mainly because of the complexity of this trait. Neonatal temperament…”
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Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response by Mancama, D, Arranz, M.J, Munro, J, Osborne, S, Makoff, A, Collier, D, Kerwin, R

“…We report the identification of four novel histamine 1 ( H1-17-C/T, -974-C/A, -1023-A/G and -1536-G/C) and four novel histamine 2 promoter polymorphisms (…”
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Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine by ARRANZ, M. J, MUNRO, J, OWEN, M, SPURLOCK, G, SHAM, P. C, ZHAO, J, KIROV, G, COLLIER, D. A, KERWIN, R. W

“…Clozapine is a potent atypical antipsychotic which binds to a variety of neurotransmitter receptors including serotonin (5-HT) receptors. However, the precise…”
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Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder by KIROV, G, MURPHY, K. C, CRADDOCK, N, ARRANZ, M. J, JONES, I, MCCANDLES, F, KUNUGI, H, MURRAY, R. M, MCGUFFIN, P, COLLIER, D. A, OWEN, M. J

“…Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines. An amino acid polymorphism (val-108-met) determines high and low…”
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Pharmacogenetic intervention in the Child and Adolescent Autism Day Therapeutic Unit by Alvarez, A, Santamaria, N, Bote, V, Medina, R, Sanchez, B, Mendez, I, Monreal, J A, Arranz, M J, Hervas, A

“…IntroductionThe ASD Therapeutic Day Unit is a tertiary care unit that consists of 20 beds, designed to facilitate the evaluation and treatment of children and…”
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A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders by Collier, D A, Stöber, G, Li, T, Heils, A, Catalano, M, Di Bella, D, Arranz, M J, Murray, R M, Vallada, H P, Bengel, D, Müller, C R, Roberts, G W, Smeraldi, E, Kirov, G, Sham, P, Lesch, K P

“…The serotonin transporter (5-HTT) is a candidate locus for aetiological involvement in affective disorders. Biochemical studies in suicides and depressed…”
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Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response by Mancama, D., Mata, I., Kerwin, R.W., Arranz, M.J.

“…Choline acetyltransferase (ChAt) is extensively distributed throughout the CNS where, by catalyzing acetylcholine synthesis, it participates in modulating…”
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Analysis of structural polymorphisms and C-1018G promoter variant of the 5-HT1A receptor gene as putative risk factors in major depression by Arias, B, Arranz, M J, Gasto, C, Catalan, R, Pintor, L, Gutierrez, B, Kerwin, R W, Fananas, L

“…MOLECULAR PSYCHIATRY: (2002) 7, 930-932. doi:10.1038/sj.mp.4001146…”
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Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients by Clark, D, Skrobot, O.A, Adebiyi, I, Susce, M.T, de Leon, J, Blakemore, AI.F, Arranz, M.J

“…Abstract Interest exists in identifying the factors that specifically contribute to the increased prevalence of cardiovascular disease observed in psychiatric…”
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5-HT2A and 5-HT2C Receptor Polymorphisms and Psychopathology in Late Onset Alzheimer's Disease by Holmes, Clive, Arranz, Maria J., Powell, John F., Collier, David A., Lovestone, Simon

“…The psychopathology of Alzheimer's disease (AD) is varied and includes both behavioural and psychological symptoms. Behavioural and psychological symptoms are…”
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No association between ADRA2A polymorphisms and schizophrenia by Clark, D.A., Mata, I., Kerwin, R.W., Munro, J., Arranz, M.J.

“…There is evidence to suggest that the α2A‐adrenergic receptor may be involved in schizophrenia. With attention directed at the upstream regulatory region of…”
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Pharmacogenetics in Psychiatry: Are We Ready for Widespread Clinical Use? by Arranz, Maria J., Kapur, Shitij

“…There are high expectations about the capabilities of pharmacogenetics to tailor psychotropic treatment and "personalize" treatment. While a large number of…”
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Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response by ARRANZ, M. J, MUNRO, J, SHAM, P, KIROV, G, MURRAY, R. M, COLLIER, D. A, KERWIN, R. W

“…Serotonin (5-HT) neurotransmitter receptors are targeted by atypical antipsychotic drugs. We hypothesized that genetic variation in these receptors may affect…”
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Association between 5-HT2A gene promoter polymorphism and anorexia nervosa by Collier, D A, Arranz, M J, Li, T, Mupita, D, Brown, N, Treasure, J

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