Search Results - "Arranz, Amaia"

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications by Arranz, Amaia M, De Strooper, Bart

“…Astrocytes, also called astroglia, maintain homoeostasis of the brain by providing trophic and metabolic support to neurons. They recycle neurotransmitters,…”
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A neuron-specific interaction between Alzheimer’s disease risk factors SORL1, APOE, and CLU by Preman, Pranav, Arranz, Amaia M.

“…Lee et al.1 report that loss of the Alzheimer’s disease risk factor SORL1 results in neuron-specific reduction in APOE and CLU, altered lipid homeostasis, and…”
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PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome by Spinazzi, Marco, Radaelli, Enrico, Horré, Katrien, Arranz, Amaia M., Gounko, Natalia V., Agostinis, Patrizia, Maia, Teresa Mendes, Impens, Francis, Moraisi, Vanessa Alexandra, Lopez-Lluch, Guillermo, Serneels, Lutgarde, Navas, Placido, De Strooper, Bart

“…The mitochondrial intramembrane rhomboid protease PARL has been implicated in diverse functions in vitro, but its physiological role in vivo remains unclear…”
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Astrocytes in Alzheimer's Disease: Pathological Significance and Molecular Pathways by Preman, Pranav, Alfonso-Triguero, Maria, Alberdi, Elena, Verkhratsky, Alexei, Arranz, Amaia M

“…Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of…”
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MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease by Balusu, Sriram, Horré, Katrien, Thrupp, Nicola, Craessaerts, Katleen, Snellinx, An, Serneels, Lutgarde, T’Syen, Dries, Chrysidou, Iordana, Arranz, Amaia M., Sierksma, Annerieke, Simrén, Joel, Karikari, Thomas K., Zetterberg, Henrik, Chen, Wei-Ting, Thal, Dietmar Rudolf, Salta, Evgenia, Fiers, Mark, De Strooper, Bart

“…Neuronal cell loss is a defining feature of Alzheimer’s disease (AD), but the underlying mechanisms remain unclear. We xenografted human or mouse neurons into…”
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Evolution of neuroglia by Verkhratsky, Alexei, Arranz, Amaia M., Ciuba, Katarzyna, Pękowska, Aleksandra

“…The evolution of the nervous system progressed through cellular diversification and specialization of functions. Conceptually, the nervous system is composed…”
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hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer's disease and potential therapeutics by Tcw, Julia, Arranz, Amaia M

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Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain by Espuny-Camacho, Ira, Arranz, Amaia M., Fiers, Mark, Snellinx, An, Ando, Kunie, Munck, Sebastian, Bonnefont, Jerome, Lambot, Laurie, Corthout, Nikky, Omodho, Lorna, Vanden Eynden, Elke, Radaelli, Enrico, Tesseur, Ina, Wray, Selina, Ebneth, Andreas, Hardy, John, Leroy, Karelle, Brion, Jean-Pierre, Vanderhaeghen, Pierre, De Strooper, Bart

“…Human pluripotent stem cells (PSCs) provide a unique entry to study species-specific aspects of human disorders such as Alzheimer’s disease (AD). However,…”
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LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism by Arranz, Amaia M, Delbroek, Lore, Van Kolen, Kristof, Guimarães, Marco R, Mandemakers, Wim, Daneels, Guy, Matta, Samer, Calafate, Sara, Shaban, Hamdy, Baatsen, Pieter, De Bock, Pieter-Jan, Gevaert, Kris, Vanden Berghe, Pieter, Verstreken, Patrik, De Strooper, Bart, Moechars, Diederik

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson’s disease, but the precise physiological function of the protein remains…”
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Brain extracellular space, hyaluronan, and the prevention of epileptic seizures by Perkins, Katherine L, Arranz, Amaia M, Yamaguchi, Yu, Hrabetova, Sabina

“…Mutant mice deficient in hyaluronan (HA) have an epileptic phenotype. HA is one of the major constituents of the brain extracellular matrix. HA has a…”
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Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space by Arranz, Amaia M, Perkins, Katherine L, Irie, Fumitoshi, Lewis, David P, Hrabe, Jan, Xiao, Fanrong, Itano, Naoki, Kimata, Koji, Hrabetova, Sabina, Yamaguchi, Yu

“…Hyaluronan (HA), a large anionic polysaccharide (glycosaminoglycan), is a major constituent of the extracellular matrix of the adult brain. To address its…”
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PLD3 gene and processing of APP by Fazzari, Pietro, Horre, Katrien, Arranz, Amaia M., Frigerio, Carlo Sala, Saito, Takashi, Saido, Takaomi C., De Strooper, Bart

“…We tested the relevance of PLD3 for APP processing in vivo in physiological conditions and in a relevant Alzheimer's disease mouse model and found that PLD3…”
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Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques by Preman, Pranav, Tcw, Julia, Calafate, Sara, Snellinx, An, Alfonso-Triguero, Maria, Corthout, Nikky, Munck, Sebastian, Thal, Dietmar Rudolf, Goate, Alison M, De Strooper, Bart, Arranz, Amaia M

“…Increasing evidence for a direct contribution of astrocytes to neuroinflammatory and neurodegenerative processes causing Alzheimer's disease comes from…”
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Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments by Guix, Francesc X, Sannerud, Ragna, Berditchevski, Fedor, Arranz, Amaia M, Horré, Katrien, Snellinx, An, Thathiah, Amantha, Saido, Takaomi, Saito, Takashi, Rajesh, Sundaresan, Overduin, Michael, Kumar-Singh, Samir, Radaelli, Enrico, Corthout, Nikky, Colombelli, Julien, Tosi, Sébastien, Munck, Sebastian, Salas, Isabel H, Annaert, Wim, De Strooper, Bart

“…The mechanisms behind Aβ-peptide accumulation in non-familial Alzheimer's disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ…”
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Archaeobotanical evidence reveals the origins of bread 14,400 years ago in northeastern Jordan by Arranz-Otaegui, Amaia, Carretero, Lara Gonzalez, Ramsey, Monica N., Fuller, Dorian Q., 傅稻镰, Richter, Tobias

“…The origins of bread have long been associated with the emergence of agriculture and cereal domestication during the Neolithic in southwest Asia. In this study…”
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Centenarian hippocampus displays high levels of astrocytic metallothioneins by Saenz‐Antoñanzas, Ander, Muñoz‐Culla, Maider, Rigo, Piero, Ruiz‐Barreiro, Leire, Moreno‐Valladares, Manuel, Alberro, Ainhoa, Cruces‐Salguero, Sara, Arroyo‐Izaga, Marta, Arranz, Amaia M., Otaegui, David, Guillemot, François, Matheu, Ander

“…The hippocampus is a brain area linked to cognition. The mechanisms that maintain cognitive activity in humans are poorly understood. Centenarians display…”
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Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity by Salas, Isabel H, Callaerts-Vegh, Zsuzsanna, Arranz, Amaia M, Guix, Francesc X, D'Hooge, Rudi, Esteban, José A, De Strooper, Bart, Dotti, Carlos G

“…Tetraspanins (Tspan) are transmembrane proteins with important scaffold and signalling functions. Deletions of Tetraspanin 6 (Tspan6) gene, a member of the…”
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P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis by Matute, Carlos, Torre, Iratxe, Pérez-Cerdá, Fernando, Pérez-Samartín, Alberto, Alberdi, Elena, Etxebarria, Estibaliz, Arranz, Amaia M, Ravid, Rivka, Rodríguez-Antigüedad, Alfredo, Sánchez-Gómez, MaríaVictoria, Domercq, María

“…Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we show that ATP signaling can trigger oligodendrocyte excitotoxicity…”
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P2X7 Receptor Blockade Prevents ATP Excitotoxicity in Oligodendrocytes and Ameliorates Experimental Autoimmune Encephalomyelitis by Matute, Carlos, Torre, Iratxe, Perez-Cerda, Fernando, Perez-Samartin, Alberto, Alberdi, Elena, Etxebarria, Estibaliz, Arranz, Amaia M, Ravid, Rivka, Rodriguez-Antiguedad, Alfredo, Sanchez-Gomez, MariaVictoria, Domercq, Maria

“…Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we show that ATP signaling can trigger oligodendrocyte excitotoxicity…”
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Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity by Salas, Isabel H, Callaerts-Vegh, Zsuzsanna, Arranz, Amaia M, Guix, Francesc X, D'Hooge, Rudi, Esteban, José A, De Strooper, Bart, Dotti, Carlos G

“…[This corrects the article DOI: 10.1371/journal.pone.0171968.]…”
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