Genital Human Papillomavirus Infection in Panama City Prostitutes

Little is known of the natural history of genital human papillomavirus (HPV) infections in women from high-risk populations. Samples were collected from 183 Panama City prostitutes and assessed for HPV (filter in situ DNA hybridization) and for sexually transmitted agents. The cohort was followed fo...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 160; no. 4; pp. 599 - 603
Main Authors:	Reeves, William C., Arosemena, Juan R., Garcia, Mariana, de Lao, Suzanne Loo, Cuevas, Marina, Quiroz, Evelia, Caussy, Deoraj, Rawls, William E.
Format:	Journal Article
Language:	English
Published:	Chicago, IL The University of Chicago Press 01-10-1989 University of Chicago Press
Subjects:	Adolescent Adult Biological and medical sciences Cohort Studies DNA DNA, Viral - analysis Female General aspects Genitalia Human infectious diseases. Experimental studies and models Human viral diseases Humans In situ hybridization Infections Infectious diseases Interviews as Topic Lesions Longitudinal Studies Major Articles Medical sciences Middle Aged Nucleic Acid Hybridization Panama - epidemiology Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus infections Recurrence Risk Factors Sex Work Sex workers Sexual Behavior Specimens Tropical medicine Tumor Virus Infections - epidemiology Tumor Virus Infections - etiology Uterine Cervical Diseases - epidemiology Uterine Cervical Diseases - etiology Viral diseases Viral DNA Viruses Panama Human Central America Molecular hybridization Papovaviridae Female genital diseases Papillomavirus Virus Prostitution Human papillomavirus DNA Panama America Cervical mucus Multiple sampling Detection Woman Southern blotting Nucleic acid Venereal disease Supervision
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Summary:	Little is known of the natural history of genital human papillomavirus (HPV) infections in women from high-risk populations. Samples were collected from 183 Panama City prostitutes and assessed for HPV (filter in situ DNA hybridization) and for sexually transmitted agents. The cohort was followed for 8 mo; 51% of subjects completed four monthly return visits and 16% were sampled eight times. The proportion of women found infected with HPV increased significantly with increasing numbers of consecutive samples tested; 38 (21%) of 183 women were positive after one visit and 46 (82%) of 56 who completed six visits were infected. The pattern of viral detection over time was not random, which implied that most prostitutes were persistently infected with genital HPVs and that either scattered foci of infection or periodic reactivation of latent virus occurred. Our findings suggest that multiple sampling is necessary to accurately estimate HPV infection rates and to define whether patterns of DNA expression are present.
Bibliography:	istex:3E891325204D59D9974287C9DE1A398334F63A86 The authors thank the medical directors and nursing staffs at the Chorrillo, Rio Abajo, Emiliano Ponce, and Boca la Caja District Health Centers; and Maria Majela Brenes, Don Manuel Guerrero, Layla de Perez, Edmundo Chandler, Basilio Gomez, Adaluz de Ince, Maritza Ramos, Maritza de Bernal, Berta Cedeno, all Gorgas Memorial Laboratory Division of Epidemiology. ark:/67375/HXZ-QJM82P2N-F 1Please address requests for reprints to Dr. W. C. Reeves at his present address: Viral Exanthems and Herpesvirus Branch, Division of Viral Diseases, Center for Infectious Diseases, CDC, Atlanta, GA 30333. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/160.4.599