Search Results - "Arora, Uma"

Population and subspecies diversity at mouse centromere satellites by Arora, Uma P, Charlebois, Caleigh, Lawal, Raman Akinyanju, Dumont, Beth L

“…Mammalian centromeres are satellite-rich chromatin domains that execute conserved roles in kinetochore assembly and chromosome segregation. Centromere…”
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Selection shapes the landscape of functional variation in wild house mice by Lawal, Raman Akinyanju, Arora, Uma P, Dumont, Beth L

“…Through human-aided dispersal over the last ~ 10,000 years, house mice (Mus musculus) have recently colonized diverse habitats across the globe, promoting the…”
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Meiotic drive in house mice: mechanisms, consequences, and insights for human biology by Arora, Uma P., Dumont, Beth L.

“…Meiotic drive occurs when one allele at a heterozygous site cheats its way into a disproportionate share of functional gametes, violating Mendel’s law of equal…”
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Variation in the CENP-A sequence association landscape across diverse inbred mouse strains by Arora, Uma P., Sullivan, Beth A., Dumont, Beth L.

“…Centromeres are crucial for chromosome segregation, but their underlying sequences evolve rapidly, imposing strong selection for compensatory changes in…”
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Inherited blood cancer predisposition through altered transcription elongation by Zhao, Jiawei, Cato, Liam D, Arora, Uma P, Bao, Erik L, Bryant, Samuel C, Williams, Nicholas, Jia, Yuemeng, Goldman, Seth R, Nangalia, Jyoti, Erb, Michael A, Vos, Seychelle M, Armstrong, Scott A, Sankaran, Vijay G

“…Despite advances in defining diverse somatic mutations that cause myeloid malignancies, a significant heritable component for these cancers remains largely…”
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Porphyrin Production and Regulation in Cutaneous Propionibacteria by Barnard, Emma, Johnson, Tremylla, Ngo, Tracy, Arora, Uma, Leuterio, Gunilla, McDowell, Andrew, Li, Huiying

“…Porphyrins are intermediate metabolites in the biosynthesis of vital molecules, including heme, cobalamin, and chlorophyll. Bacterial porphyrins are known to…”
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Centromere innovations within a mouse species by Gambogi, Craig W, Pandey, Nootan, Dawicki-McKenna, Jennine M, Arora, Uma P, Liskovykh, Mikhail A, Ma, Jun, Lamelza, Piero, Larionov, Vladimir, Lampson, Michael A, Logsdon, Glennis A, Dumont, Beth L, Black, Ben E

“…Mammalian centromeres direct faithful genetic inheritance and are typically characterized by regions of highly repetitive and rapidly evolving DNA. We focused…”
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Polygenic Modifiers of Expressivity in Telomere Biology Disorders by Poeschla, Michael, Arora, Uma, McReynolds, Lisa J, Machiela, Mitchell, Savage, Sharon, Sankaran, Vijay G.

“…Telomere biology disorders (TBDs) are caused by pathogenic germline variants in genes involved in telomere maintenance resulting in very short telomeres for…”
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Centromere Innovations with a Mouse Species by Pandey, Nootan, Gambogi, Craig, Dawicki‐McKenna, Jennine, Arora, Uma, Logsdon, Glennis, Ma, Jun, Lamelza, Piero, Lampson, Michael A., Dumont, Beth, Black, Ben E.

“…Mammalian centromeres direct faithful genetic inheritance at cell division and are typically found in regions of highly repetitive DNA, such as a‐satellite in…”
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Novel N‑Linked Aminopiperidine-Based Gyrase Inhibitors with Improved hERG and in Vivo Efficacy against Mycobacterium tuberculosis by Hameed P, Shahul, Patil, Vikas, Solapure, Suresh, Sharma, Umender, Madhavapeddi, Prashanti, Raichurkar, Anandkumar, Chinnapattu, Murugan, Manjrekar, Praveena, Shanbhag, Gajanan, Puttur, Jayashree, Shinde, Vikas, Menasinakai, Sreenivasaiah, Rudrapatana, Suresh, Achar, Vijayashree, Awasthy, Disha, Nandishaiah, Radha, Humnabadkar, Vaishali, Ghosh, Anirban, Narayan, Chandan, Ramya, V. K, Kaur, Parvinder, Sharma, Sreevalli, Werngren, Jim, Hoffner, Sven, Panduga, Vijender, Kumar, C. N. Naveen, Reddy, Jitendar, Kumar KN, Mahesh, Ganguly, Samit, Bharath, Sowmya, Bheemarao, Ugarkar, Mukherjee, Kakoli, Arora, Uma, Gaonkar, Sheshagiri, Coulson, Michelle, Waterson, David, Sambandamurthy, Vasan K, de Sousa, Sunita M

“…DNA gyrase is a clinically validated target for developing drugs against Mycobacterium tuberculosis (Mtb). Despite the promise of fluoroquinolones (FQs) as…”
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An unusual case of familial hyperlipidaemia by Nagar, Renu, Arora, Uma

“…A 40 days old male baby born to a consanguineous couple was found to have highly viscous and milky serum with caking of chylomicrons on refrigeration of serum…”
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Basalin induced neurotoxic effects in broiler chicks by Rishi, Sushma, Arora, Uma

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Changes in vitamin C and vitamin E during oxidative stress in myocardial reperfusion by Sood, Reema, Narang, A P S, Abraham, Rebecca, Arora, Uma, Calton, Rajneesh, Sood, Nitin

“…Injury to the myocardial tissue due to ischemia and reperfusion occurs because of imbalance between the formation of oxidants and available antioxidants in the…”
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Tetrathiomolybdate in the treatment of acute hepatitis in an animal model for Wilson disease by Klein, Dominik, Arora, Uma, Lichtmannegger, Josef, Finckh, Matthias, Heinzmann, Ulrich, Summer, Karl H

“…Tetrathiomolybdate (TTM) is a potent copper-chelating agent that has been shown to be effective in Wilson disease patients with neurological symptoms. Here, we…”
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Quantification of oxidized metallothionein by a Cd-saturation method by Klein, Dominik, Arora, Uma, Sato, Shin, Summer, Karl H

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