Search Results - "Arora, P. D."

Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator by Chen, A., Arora, P. D., McCulloch, C. A., Wilde, A.

“…Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the…”
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Flightless Anchors IQGAP1 and R-ras to Mediate Cell Extension Formation and Matrix Remodeling by Arora, P D, Nakajima, K, Nanda, A, Plaha, A, Wilde, A, Sacks, D B, McCulloch, C A

“…Tractional remodeling of collagen fibrils by fibroblasts requires long cell extensions that mediate fibril alignment. The formation of these cell extensions…”
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The Compliance of Collagen Gels Regulates Transforming Growth Factor-β Induction of α-Smooth Muscle Actin in Fibroblasts by Arora, Pamela D., Narani, Nazanin, McCulloch, Christopher A.G.

“…Wound contraction is mediated by myofibroblasts, specialized fibroblasts that appear in large numbers as the wound matures and when resistance to contractile…”
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Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2 by Arora, P D, Marignani, P A, McCulloch, C A

“…Collagen phagocytosis is a crucial alpha2beta1-integrin-dependent process that mediates extracellular matrix remodeling by fibroblasts. We showed previously…”
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Separate functions of gelsolin mediate sequential steps of collagen phagocytosis by Arora, P D, Chan, M W C, Anderson, R A, Janmey, P A, McCulloch, C A

“…Collagen phagocytosis is a critical mediator of extracellular matrix remodeling. Whereas the binding step of collagen phagocytosis is facilitated by…”
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The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation by Arora, P D, He, T, Ng, K, McCulloch, C A

“…Flightless I (FliI) is a calcium-dependent, actin severing and capping protein that localizes to cell matrix adhesions, contributes to the generation of cell…”
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Dependence of collagen remodelling on alpha-smooth muscle actin expression by fibroblasts by Arora, P D, McCulloch, C A

“…To study the relation between expression of the putative myofibroblast marker alpha-smooth muscle actin and the remodelling of extracellular matrix,…”
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The Deletion of Transforming Growth Factor-β-Induced Myofibroblasts Depends on Growth Conditions and Actin Organization by Arora, Pamela D., McCulloch, Christopher A.G.

“…Myofibroblasts are important but transient mediators of normal wound contraction and are characterized phenotypically by their high levels of α-smooth-muscle…”
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Collagen remodeling by phagocytosis is determined by collagen substrate topology and calcium-dependent interactions of gelsolin with nonmuscle myosin IIA in cell adhesions by Arora, P D, Wang, Y, Bresnick, A, Dawson, J, Janmey, P A, McCulloch, C A

“…We examine how collagen substrate topography, free intracellular calcium ion concentration ([Ca(2+)]i, and the association of gelsolin with nonmuscle myosin…”
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A Role for Gelsolin in Stress Fiber-Dependent Cell Contraction by Arora, P.D., Janmey, P.A., McCulloch, C.A.G.

“…Gelsolin is an abundant actin binding protein that mediates the rapid remodeling of cortical actin filaments through severing, capping, and nucleating…”
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Cadherins Mediate Intercellular Mechanical Signaling in Fibroblasts by Activation of Stretch-sensitive Calcium-permeable Channels by Ko, Kevin S., Arora, Pamela D., McCulloch, Christopher A.G.

“…Cells in mechanically active environments form extensive, cadherin-mediated intercellular junctions that are important in tissue remodeling and…”
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A Novel Model System for Characterization of Phagosomal Maturation, Acidification, and Intracellular Collagen Degradation in Fibroblasts by Arora, Pamela D., Manolson, Morris F., Downey, Gregory P., Sodek, Jaro, McCulloch, Christopher A.G.

“…Intracellular collagen degradation by fibroblasts is an important but poorly understood pathway for the physiological remodeling of mature connective tissues…”
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Cell-cell adhesion in human fibroblasts requires calcium signaling by Ko, K S, Arora, P D, Bhide, V, Chen, A, McCulloch, C A

“…In connective tissues, intercellular adhesion is essential for tissue morphogenesis, development and wound healing. However, the signaling mechanisms initiated…”
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Involvement of actin filaments and integrins in the binding step in collagen phagocytosis by human fibroblasts by Segal, G, Lee, W, Arora, P D, McKee, M, Downey, G, McCulloch, C A

“…In physiological conditions, collagen degradation by fibroblasts occurs primarily via phagocytosis, an intracellular pathway that is thought to require…”
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Regulation of Tension-induced Mechanotranscriptional Signals by the Microtubule Network in Fibroblasts by D'Addario, Mario, Arora, Pamela D., Ellen, Richard P., McCulloch, Christopher A.G.

“…Mechanical loading of connective tissues induces the expression of extracellular matrix and cytoskeletal genes that are involved in matrix remodeling. These…”
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Dependence of Fibroblast Migration on Actin Severing Activity of Gelsolin by Arora, Pamela D., McCulloch, Christopher A.G.

“…Gelsolin nucleates actin filament assembly, blocks the fast-exchanging ends of actin filaments, and severs filaments, processes that may play an important role…”
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Mechanism of Cyclosporin-induced Inhibition of Intracellular Collagen Degradation by Arora, P D, Silvestri, L, Ganss, B, Sodek, J, McCulloch, C A

“…The immunosuppressant cyclosporin A (CsA) markedly inhibits collagen degradation by an intracellular phagocytic pathway in fibroblasts, an effect that can lead…”
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Differential binding to dorsal and ventral cell surfaces of fibroblasts: effect on collagen phagocytosis by Arora, Pamela D, Fan, Lingzhi, Sodek, Jaro, Kapus, András, McCulloch, Christopher A

“…Matrix remodeling by phagocytic fibroblasts is essential for growth and development but the regulatory processes are undefined. We evaluated the impact of…”
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Interleukin-1-induced Calcium Flux in Human Fibroblasts Is Mediated through Focal Adhesions by Min, Weixian, Cruz, Tony, Arora, Pamela D., Ma, Johnny, McCulloch, Christopher A.G.

“…Interleukin-1 (IL-1) is an important mediator of inflammation and also modulates fibroblast metabolism. To assess mechanisms of IL-1-induced signal…”
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Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch by Arora, P D, Bibby, K J, McCulloch, C A

“…Calcium transients in single, human gingival fibroblasts were studied after mechanical stretching of flexible culture substrates. A model system was developed…”
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