Search Results - "Arora, Jayant"

Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity by Arora, Jayant, Hu, Yue, Esfandiary, Reza, Sathish, Hasige A, Bishop, Steven M, Joshi, Sangeeta B, Middaugh, C Russell, Volkin, David B, Weis, David D

“…Concentration-dependent reversible self-association (RSA) of monoclonal antibodies (mAbs) poses a challenge to their pharmaceutical development as viable…”
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A self-amplifying RNA RSV prefusion-F vaccine elicits potent immunity in pre-exposed and naïve non-human primates by Vijayan, Aneesh, Vogels, Ronald, Groppo, Rachel, Jin, Yi, Khan, Selina, Van Kampen, Mirjam, Jorritsma, Sytze, Boedhoe, Satish, Baert, Miranda, van Diepen, Harry, Kuipers, Harmjan, Serroyen, Jan, del Valle, Jorge Reyes, Broman, Ann, Nguyen, Lannie, Ray, Sayoni, Jarai, Bader, Arora, Jayant, Lifton, Michelle, Mildenberg, Benjamin, Morton, Georgeanna, Santra, Sampa, Grossman, Tamar R., Schuitemaker, Hanneke, Custers, Jerome, Zahn, Roland

“…Newly approved subunit and mRNA vaccines for respiratory syncytial virus (RSV) demonstrate effectiveness in preventing severe disease, with protection…”
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Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1 by Hu, Yue, Arora, Jayant, Joshi, Sangeeta B, Esfandiary, Reza, Middaugh, C Russell, Weis, David D, Volkin, David B

“…Many challenges limit the formulation of antibodies as high-concentration liquid dosage forms including elevated solution viscosity, decreased physical…”
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Minimizing Carry-Over in an Online Pepsin Digestion System used for the H/D Exchange Mass Spectrometric Analysis of an IgG1 Monoclonal Antibody by MAJUMDAR, Ranajoy, MANIKWAR, Prakash, HICKEY, John M, ARORA, Jayant, RUSSELL MIDDAUGH, C, VOLKIN, David B, WEIS, David D

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Correlating the Effects of Antimicrobial Preservatives on Conformational Stability, Aggregation Propensity, and Backbone Flexibility of an IgG1 mAb by Arora, Jayant, Joshi, Sangeeta B, Middaugh, C Russell, Weis, David D, Volkin, David B

“…Multidose formulations of biotherapeutics, which offer better dosage management and reduced production costs, require the addition of antimicrobial…”
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Minimizing Carry-Over in an Online Pepsin Digestion System used for the H/D Exchange Mass Spectrometric Analysis of an IgG1 Monoclonal Antibody by Majumdar, Ranajoy, Manikwar, Prakash, Hickey, John M., Arora, Jayant, Middaugh, C. Russell, Volkin, David B., Weis, David D.

“…Chromatographic carry-over can severely distort measurements of amide H/D exchange in proteins analyzed by LC/MS. In this work, we explored the origin of…”
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Towards a greater mechanistic understanding of reversible protein-protein interactions and irreversible aggregation of IgG1 monoclonal antibodies by Arora, Jayant

“…Immunoglobulin G1 monoclonal antibodies (IgG1-mAbs) are one of the most important and fastest growing class of biotherapeutic agents. These mAbs are being used…”
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Site-Specific Hydrolysis Reaction C‑Terminal of Methionine in Met-His during Metal-Catalyzed Oxidation of IgG‑1 by Mozziconacci, Olivier, Arora, Jayant, Toth, Ronald T, Joshi, Sangeeta B, Zhou, Shuxia, Volkin, David B, Schöneich, Christian

“…The metal-catalyzed oxidation by [FeII(EDTA)]2–/H2O2 of IgG-1 leads to the site-specific hydrolysis of peptide bonds in the Fc region. The major hydrolytic…”
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Dislocation of the carpal scaphoid: A case report by Arora, Jayant, Pillai, Anand

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Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody by Arora, Jayant, Hickey, John M, Majumdar, Ranajoy, Esfandiary, Reza, Bishop, Steven M, Samra, Hardeep S, Middaugh, C Russell, Weis, David D, Volkin, David B

“…There is a need for new analytical approaches to better characterize the nature of the concentration-dependent, reversible self-association (RSA) of monoclonal…”
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Design of real-time combustion feedback system and experimental study of an RCCI engine for control by Arora, Jayant Kumar

“…Premixed compression ignition (PCI) technologies offer high efficiency and low emissions but are usually confined by limited operation range as well as high…”
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Transulnar styloid palmar scapho-lunate dislocation with median nerve injury by Arora, Jayant

“…A patient with a transulnar styloid palmar scapho-lunate dislocation with median nerve injury is described. The dislocation could be reduced by closed…”
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Bacillus cereus: the forgotten pathogen by Pillai, Anand, Thomas, Stephanie, Arora, Jayant

“…Infection with Bacillus cereus is generally associated with gastrointestinal effects of food poisoning linked to infected rice. Isolates of B. cereus in…”
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Analyzing Sensor-based Technologies for Obstacle Avoidance Robot by Pawar, Lokesh, Bawa, Guladab, Mehra, Chaitanya, Kanojia, Sahil, Arora, Jayant, Bajaj, Rohit

“…In recent years, the use of advanced robotic systems has increased significantly, making machinery quite effective and productive. A robot is an advanced…”
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External fixation in comminuted, displaced intra-articular fractures of the distal radius: is it sufficient? by Arora, J, Malik, A C

“…External fixation has been extensively used to treat the intra-articular fractures of the distal radius and it has several distinct advantages over…”
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Modeling, design and implementation of a closed-loop combustion controller for an RCCI engine by Kondipati, Naga Nithin Teja, Arora, Jayant Kumar, Bidarvatan, Mehran, Shahbakhti, Mahdi

“…Reactivity Controlled Compression Ignition (RCCI) is a promising low temperature combustion strategy with high thermal efficiency and effective means to…”
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Osteolysis in a surface-cemented, primary, modular Freeman-Samuelson total knee replacement by ARORA, J, OGDEN, A. C

“…We analysed at a mean follow-up of 7.25 years the clinical and radiological outcome of 117 patients (125 knees) who had undergone a primary, cemented, modular…”
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Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity by Arora, Jayant, Hu, Yue, Esfandiary, Reza, Sathish, Hasige A., Bishop, Steven M., Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B., Weis, David D.

“…Concentration-dependent reversible self-association (RSA) of monoclonal antibodies (mAbs) poses a challenge to their pharmaceutical development as viable…”
Get full text