Search Results - "Arora, Gurpreet K"

Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis by Muta, Yu, Linares, Juan F., Martinez-Ordoñez, Anxo, Duran, Angeles, Cid-Diaz, Tania, Kinoshita, Hiroto, Zhang, Xiao, Han, Qixiu, Nakanishi, Yuki, Nakanishi, Naoko, Cordes, Thekla, Arora, Gurpreet K., Ruiz-Martinez, Marc, Reina-Campos, Miguel, Kasashima, Hiroaki, Yashiro, Masakazu, Maeda, Kiyoshi, Albaladejo-Gonzalez, Ana, Torres-Moreno, Daniel, García-Solano, José, Conesa-Zamora, Pablo, Inghirami, Giorgio, Metallo, Christian M., Osborne, Timothy F., Diaz-Meco, Maria T., Moscat, Jorge

“…The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are…”
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Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin by Arora, Gurpreet K, Gupta, Arun, Narayanan, Sriram, Guo, Tong, Iyengar, Puneeth, Infante, Rodney E

“…Cachexia syndrome consists of adipose and muscle loss, often despite normal food intake. We hypothesized that cachexia-associated adipose wasting is driven in…”
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Expanding role of PI5P4Ks in cancer: A promising druggable target by Arora, Gurpreet K., Palamiuc, Lavinia, Emerling, Brooke M.

“…Cancer cells are challenged by a myriad of microenvironmental stresses, and it is their ability to efficiently adapt to the constantly changing nutrient,…”
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Janus kinase inhibitors suppress cancer cachexia‐associated anorexia and adipose wasting in mice by Arora, Gurpreet K., Gupta, Arun, Guo, Tong, Gandhi, Aakash Y., Laine, Aaron, Williams, Dorothy L., Ahn, Chul, Iyengar, Puneeth, Infante, Rodney E.

“…Background Cachexia, a syndrome of muscle atrophy, adipose loss, and anorexia, is associated with reduced survival in cancer patients. The colon adenocarcinoma…”
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PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay by Ravi, Archna, Palamiuc, Lavinia, Loughran, Ryan M., Triscott, Joanna, Arora, Gurpreet K., Kumar, Avi, Tieu, Vivian, Pauli, Chantal, Reist, Matthias, Lew, Rachel J., Houlihan, Shauna L., Fellmann, Christof, Metallo, Christian, Rubin, Mark A., Emerling, Brooke M.

“…PI5P4Ks are a class of phosphoinositide kinases that phosphorylate PI-5-P to PI-4,5-P2. Distinct localization of phosphoinositides is fundamental for a…”
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PIP kinases: A versatile family that demands further therapeutic attention by Llorente, Alicia, Arora, Gurpreet K., Grenier, Shea F., Emerling, Brooke M.

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Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP by Palamiuc, Lavinia, Johnson, Jared L, Haratipour, Zeinab, Loughran, Ryan M, Choi, Woong Jae, Arora, Gurpreet K, Tieu, Vivian, Ly, Kyanh, Llorente, Alicia, Crabtree, Sophia, Wong, Jenny C Y, Ravi, Archna, Wiederhold, Thorsten, Murad, Rabi, Blind, Raymond D, Emerling, Brooke M

“…Phosphoinositides are essential signaling molecules. The PI5P4K family of phosphoinositide kinases and their substrates and products, PI5P and PI4,5P ,…”
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Temporal control of bidirectional lipid-droplet motion in Drosophila depends on the ratio of kinesin-1 and its co-factor Halo by Arora, Gurpreet K, Tran, Susan L, Rizzo, Nicholas, Jain, Ankit, Welte, Michael A

“…During bidirectional transport, individual cargoes move continuously back and forth along microtubule tracks, yet the cargo population overall displays…”
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PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition by Triscott, Joanna, Reist, Matthias, Küng, Lukas, Mosele, Francielle C, Lehner, Marika, Gallon, John, Ravi, Archna, Arora, Gurpreet K, de Brot, Simone, Lundquist, Mark, Gallart-Ayala, Hector, Ivanisevic, Julijana, Piscuoglio, Salvatore, Cantley, Lewis C, Emerling, Brooke M, Rubin, Mark A

“…Phosphatidylinositol (PI)regulating enzymes are frequently altered in cancer and have become a focus for drug development. Here, we explore the…”
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