Search Results - "Aronow, Bruce J"

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice by Olsson, Andre, Venkatasubramanian, Meenakshi, Chaudhri, Viren K., Aronow, Bruce J., Salomonis, Nathan, Singh, Harinder, Grimes, H. Leighton

“…Stem cells generate progenitors that transition through a series of dynamically unstable states with mixed-lineage gene expression, culminating in the…”
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Genetic lineage tracing defines myofibroblast origin and function in the injured heart by Kanisicak, Onur, Khalil, Hadi, Ivey, Malina J., Karch, Jason, Maliken, Bryan D., Correll, Robert N., Brody, Matthew J., J. Lin, Suh-Chin, Aronow, Bruce J., Tallquist, Michelle D., Molkentin, Jeffery D.

“…Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute myocardial infarction (MI) and to mediate long-standing fibrosis with…”
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Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection by Wilson, Elizabeth B., Yamada, Douglas H., Elsaesser, Heidi, Herskovitz, Jonathan, Deng, Jane, Cheng, Genhong, Aronow, Bruce J., Karp, Christopher L., Brooks, David G.

“…Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is associated with hyperimmune activation and disease…”
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The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor by Powell, Anne E., Wang, Yang, Li, Yina, Poulin, Emily J., Means, Anna L., Washington, Mary K., Higginbotham, James N., Juchheim, Alwin, Prasad, Nripesh, Levy, Shawn E., Guo, Yan, Shyr, Yu, Aronow, Bruce J., Haigis, Kevin M., Franklin, Jeffrey L., Coffey, Robert J.

“…Lineage mapping has identified both proliferative and quiescent intestinal stem cells, but the molecular circuitry controlling stem cell quiescence is…”
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Disease candidate gene identification and prioritization using protein interaction networks by Chen, Jing, Aronow, Bruce J, Jegga, Anil G

“…Although most of the current disease candidate gene identification and prioritization methods depend on functional annotations, the coverage of the gene…”
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Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis by Higashi, Atsuko Y, Aronow, Bruce J, Dressler, Gregory R

“…Renal interstitial fibrosis results from activation and proliferation of fibroblasts to myofibroblasts, secretion and accumulation of extracellular matrix, and…”
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Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response by Haberman, Yael, Karns, Rebekah, Dexheimer, Phillip J., Schirmer, Melanie, Somekh, Judith, Jurickova, Ingrid, Braun, Tzipi, Novak, Elizabeth, Bauman, Laura, Collins, Margaret H., Mo, Angela, Rosen, Michael J., Bonkowski, Erin, Gotman, Nathan, Marquis, Alison, Nistel, Mason, Rufo, Paul A., Baker, Susan S., Sauer, Cary G., Markowitz, James, Pfefferkorn, Marian D., Rosh, Joel R., Boyle, Brendan M., Mack, David R., Baldassano, Robert N., Shah, Sapana, Leleiko, Neal S., Heyman, Melvin B., Grifiths, Anne M., Patel, Ashish S., Noe, Joshua D., Aronow, Bruce J., Kugathasan, Subra, Walters, Thomas D., Gibson, Greg, Thomas, Sonia Davis, Mollen, Kevin, Shen-Orr, Shai, Huttenhower, Curtis, Xavier, Ramnik J., Hyams, Jeffrey S., Denson, Lee A.

“…Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define…”
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Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling by Giles, Daniel A, Moreno-Fernandez, Maria E, Stankiewicz, Traci E, Graspeuntner, Simon, Cappelletti, Monica, Wu, David, Mukherjee, Rajib, Chan, Calvin C, Lawson, Matthew J, Klarquist, Jared, Sünderhauf, Annika, Softic, Samir, Kahn, C Ronald, Stemmer, Kerstin, Iwakura, Yoichiro, Aronow, Bruce J, Karns, Rebekah, Steinbrecher, Kris A, Karp, Christopher L, Sheridan, Rachel, Shanmukhappa, Shiva K, Reynaud, Damien, Haslam, David B, Sina, Christian, Rupp, Jan, Hogan, Simon P, Divanovic, Senad

“…Current mouse models of nonalcoholic steatohepatitis are limited, making identification and preclinical testing of new treatments challenging. Housing mice at…”
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A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development by Xu, Jingyue, Liu, Han, Lan, Yu, Aronow, Bruce J, Kalinichenko, Vladimir V, Jiang, Rulang

“…Cleft palate is among the most common birth defects in humans. Previous studies have shown that Shh signaling plays critical roles in palate development and…”
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A Thrombospondin-Dependent Pathway for a Protective ER Stress Response by Lynch, Jeffrey M., Maillet, Marjorie, Vanhoutte, Davy, Schloemer, Aryn, Sargent, Michelle A., Blair, N. Scott, Lynch, Kaari A., Okada, Tetsuya, Aronow, Bruce J., Osinska, Hanna, Prywes, Ron, Lorenz, John N., Mori, Kazutoshi, Lawler, Jack, Robbins, Jeffrey, Molkentin, Jeffery D.

“…Thrombospondin (Thbs) proteins are induced in sites of tissue damage or active remodeling. The endoplasmic reticulum (ER) stress response is also prominently…”
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MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors by Jessen, Walter J, Miller, Shyra J, Jousma, Edwin, Wu, Jianqiang, Rizvi, Tilat A, Brundage, Meghan E, Eaves, David, Widemann, Brigitte, Kim, Mi-Ok, Dombi, Eva, Sabo, Jessica, Hardiman Dudley, Atira, Niwa-Kawakita, Michiko, Page, Grier P, Giovannini, Marco, Aronow, Bruce J, Cripe, Timothy P, Ratner, Nancy

“…Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve…”
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Improved human disease candidate gene prioritization using mouse phenotype by Chen, Jing, Xu, Huan, Aronow, Bruce J, Jegga, Anil G

“…The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors…”
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Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease by Marigorta, Urko M, Denson, Lee A, Hyams, Jeffrey S, Mondal, Kajari, Prince, Jarod, Walters, Thomas D, Griffiths, Anne, Noe, Joshua D, Crandall, Wallace V, Rosh, Joel R, Mack, David R, Kellermayer, Richard, Heyman, Melvin B, Baker, Susan S, Stephens, Michael C, Baldassano, Robert N, Markowitz, James F, Kim, Mi-Ok, Dubinsky, Marla C, Cho, Judy, Aronow, Bruce J, Kugathasan, Subra, Gibson, Greg

“…Greg Gibson and colleagues integrate summary-level GWAS and eQTL data with RNA-seq data from a cohort of pediatric Crohn's disease and report transcriptional…”
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Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan by Chen, Shuang, Brunskill, Eric W., Potter, S. Steven, Dexheimer, Phillip J., Salomonis, Nathan, Aronow, Bruce J., Hong, Christian I., Zhang, Tongli, Kopan, Raphael

“…During fetal development, nephrons of the metanephric kidney form from a mesenchymal progenitor population that differentiates en masse before or shortly after…”
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Computational drug repositioning through heterogeneous network clustering by Wu, Chao, Gudivada, Ranga C, Aronow, Bruce J, Jegga, Anil G

“…Given the costly and time consuming process and high attrition rates in drug discovery and development, drug repositioning or drug repurposing is considered as…”
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African Americans and European Americans exhibit distinct gene expression patterns across tissues and tumors associated with immunologic functions and environmental exposures by Singh, Urminder, Hernandez, Kyle M., Aronow, Bruce J., Wurtele, Eve Syrkin

“…The COVID-19 pandemic has affected African American populations disproportionately with respect to prevalence, and mortality. Expression profiles represent…”
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Guided construction of single cell reference for human and mouse lung by Guo, Minzhe, Morley, Michael P., Jiang, Cheng, Wu, Yixin, Li, Guangyuan, Du, Yina, Zhao, Shuyang, Wagner, Andrew, Cakar, Adnan Cihan, Kouril, Michal, Jin, Kang, Gaddis, Nathan, Kitzmiller, Joseph A., Stewart, Kathleen, Basil, Maria C., Lin, Susan M., Ying, Yun, Babu, Apoorva, Wikenheiser-Brokamp, Kathryn A., Mun, Kyu Shik, Naren, Anjaparavanda P., Clair, Geremy, Adkins, Joshua N., Pryhuber, Gloria S., Misra, Ravi S., Aronow, Bruce J., Tickle, Timothy L., Salomonis, Nathan, Sun, Xin, Morrisey, Edward E., Whitsett, Jeffrey A., Xu, Yan

“…Accurate cell type identification is a key and rate-limiting step in single-cell data analysis. Single-cell references with comprehensive cell types,…”
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Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis by Rochman, Mark, PhD, Travers, Jared, BS, Miracle, Cora E, Bedard, Mary C., BS, Wen, Ting, PhD, Azouz, Nurit P., PhD, Caldwell, Julie M., PhD, KC, Kiran, BS, Sherrill, Joseph D., PhD, Davis, Benjamin P., MD, PhD, Rymer, Jeffrey K., BS, Kaufman, Kenneth M., PhD, Aronow, Bruce J., PhD, Rothenberg, Marc E., MD, PhD

“…Background A key question in the allergy field is to understand how tissue-specific disease is manifested. Eosinophilic esophagitis (EoE) is an emerging…”
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Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism by Millay, Douglas P, Goonasekera, Sanjeewa A, Sargent, Michelle A, Maillet, Marjorie, Aronow, Bruce J, Molkentin, Jeffery D

“…Muscular dystrophy is a general term encompassing muscle disorders that cause weakness and wasting, typically leading to premature death. Membrane instability,…”
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Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer by Bedard, Mary C., Chihanga, Tafadzwa, Carlile, Adrean, Jackson, Robert, Brusadelli, Marion G., Lee, Denis, VonHandorf, Andrew, Rochman, Mark, Dexheimer, Phillip J., Chalmers, Jeffrey, Nuovo, Gerard, Lehn, Maria, Williams, David E. J., Kulkarni, Aditi, Carey, Molly, Jackson, Amanda, Billingsley, Caroline, Tang, Alice, Zender, Chad, Patil, Yash, Wise-Draper, Trisha M., Herzog, Thomas J., Ferris, Robert L., Kendler, Ady, Aronow, Bruce J., Kofron, Matthew, Rothenberg, Marc E., Weirauch, Matthew T., Van Doorslaer, Koenraad, Wikenheiser-Brokamp, Kathryn A., Lambert, Paul F., Adam, Mike, Steven Potter, S., Wells, Susanne I.

“…Persistent HPV16 infection is a major cause of the global cancer burden. The viral life cycle is dependent on the differentiation program of stratified…”
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