Search Results - "Aronica, Eleonora"

Inflammation in epilepsy: Clinical observations by Aronica, Eleonora, Crino, Peter B.

“…Summary Over the past decade, an increasing number of observations indicate that activation of inflammatory processes occurs in variety of focal epilepsies…”
Get full text

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis by Garofalo, Stefano, Cocozza, Germana, Porzia, Alessandra, Inghilleri, Maurizio, Raspa, Marcello, Scavizzi, Ferdinando, Aronica, Eleonora, Bernardini, Giovanni, Peng, Ling, Ransohoff, Richard M., Santoni, Angela, Limatola, Cristina

“…In amyotrophic lateral sclerosis (ALS), immune cells and glia contribute to motor neuron (MN) degeneration. We report the presence of NK cells in post-mortem…”
Get full text

Hepatitis E Virus Infects Neurons and Brains by Zhou, Xinying, Huang, Fen, Xu, Lei, Lin, Zhanmin, de Vrij, Femke M. S., Ayo-Martin, Ane C., van der Kroeg, Mark, Zhao, Manzhi, Yin, Yuebang, Wang, Wenshi, Cao, Wanlu, Wang, Yijin, Kushner, Steven A., Peron, Jean Marie, Alric, Laurent, de Man, Robert A., Jacobs, Bart C., van Eijk, Jeroen J., Aronica, Eleonora M. A., Sprengers, Dave, Metselaar, Herold J., de Zeeuw, Chris I., Dalton, Harry R., Kamar, Nassim, Peppelenbosch, Maikel P., Pan, Qiuwei

“…Hepatitis E virus (HEV), as a hepatotropic virus, is supposed to exclusively infect the liver and only cause hepatitis. However, a broad range of extrahepatic…”
Get full text

Long-Term Epilepsy-Associated Tumors by Thom, Maria, Blümcke, Ingmar, Aronica, Eleonora

“…The term long‐term epilepsy associated tumor (LEAT) encompasses lesions identified in patients investigated for long histories (often 2 years or more) of…”
Get full text

Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury by van Vliet, Erwin A., Ndode-Ekane, Xavier Ekolle, Lehto, Lauri J., Gorter, Jan A., Andrade, Pedro, Aronica, Eleonora, Gröhn, Olli, Pitkänen, Asla

“…Traumatic brain injury (TBI) causes 10–20% of acquired epilepsy, which typically develops within 2 years post-injury with poorly understood mechanisms. We…”
Get full text

mTOR dysregulation and tuberous sclerosis-related epilepsy by Curatolo, Paolo, Moavero, Romina, van Scheppingen, Jackelien, Aronica, Eleonora

“…The mammalian target of rapamycin (mTOR) pathway has emerged as a key player for proper neural network development, and it is involved in epileptogenesis…”
Get more information

Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis by Gorter, Jan A, van Vliet, Erwin A, Aronica, Eleonora

“…Abstract Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic…”
Get full text

Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study by Schurink, Bernadette, Roos, Eva, Radonic, Teodora, Barbe, Ellis, Bouman, Catherine S C, de Boer, Hans H, de Bree, Godelieve J, Bulle, Esther B, Aronica, Eleonora M, Florquin, Sandrine, Fronczek, Judith, Heunks, Leo M A, de Jong, Menno D, Guo, Lihui, du Long, Romy, Lutter, Rene, Molenaar, Pam C G, Neefjes-Borst, E Andra, Niessen, Hans W M, van Noesel, Carel J M, Roelofs, Joris J T H, Snijder, Eric J, Soer, Eline C, Verheij, Joanne, Vlaar, Alexander P J, Vos, Wim, van der Wel, Nicole N, van der Wal, Allard C, van der Valk, Paul, Bugiani, Marianna

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets multiple organs and causes severe coagulopathy. Histopathological organ changes might not…”
Get full text

Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model by Bruinsma, Caroline F, Schonewille, Martijn, Gao, Zhenyu, Aronica, Eleonora M A, Judson, Matthew C, Philpot, Benjamin D, Hoebeek, Freek E, van Woerden, Geeske M, De Zeeuw, Chris I, Elgersma, Ype

“…Angelman syndrome (AS) is a severe neurological disorder that is associated with prominent movement and balance impairments that are widely considered to be…”
Get full text

The ILAE consensus classification of focal cortical dysplasia: An update proposed by an ad hoc task force of the ILAE diagnostic methods commission by Najm, Imad, Lal, Dennis, Alonso Vanegas, Mario, Cendes, Fernando, Lopes‐Cendes, Iscia, Palmini, Andre, Paglioli, Eliseu, Sarnat, Harvey B., Walsh, Christopher A., Wiebe, Samuel, Aronica, Eleonora, Baulac, Stéphanie, Coras, Roland, Kobow, Katja, Cross, J. Helen, Garbelli, Rita, Holthausen, Hans, Rössler, Karl, Thom, Maria, El‐Osta, Assam, Lee, Jeong Ho, Miyata, Hajime, Guerrini, Renzo, Piao, Yue‐Shan, Zhou, Dong, Blümcke, Ingmar

“…Ongoing challenges in diagnosing focal cortical dysplasia (FCD) mandate continuous research and consensus agreement to improve disease definition and…”
Get full text

Muscle abnormalities worsen after post-exertional malaise in long COVID by Appelman, Brent, Charlton, Braeden T., Goulding, Richie P., Kerkhoff, Tom J., Breedveld, Ellen A., Noort, Wendy, Offringa, Carla, Bloemers, Frank W., van Weeghel, Michel, Schomakers, Bauke V., Coelho, Pedro, Posthuma, Jelle J., Aronica, Eleonora, Joost Wiersinga, W., van Vugt, Michèle, Wüst, Rob C. I.

“…A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is…”
Get full text

Advances in the development of biomarkers for epilepsy by Pitkänen, Asla, Prof, Löscher, Wolfgang, Prof, Vezzani, Annamaria, Prof, Becker, Albert J, Prof, Simonato, Michele, Prof, Lukasiuk, Katarzyna, Prof, Gröhn, Olli, Prof, Bankstahl, Jens P, PhD, Friedman, Alon, Prof, Aronica, Eleonora, Prof, Gorter, Jan A, Prof, Ravizza, Teresa, PhD, Sisodiya, Sanjay M, Prof, Kokaia, Merab, Prof, Beck, Heinz, Prof

“…Summary Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of…”
Get full text

International consensus recommendations on the diagnostic work-up for malformations of cortical development by Oegema, Renske, Barakat, Tahsin Stefan, Wilke, Martina, Stouffs, Katrien, Amrom, Dina, Aronica, Eleonora, Bahi-Buisson, Nadia, Conti, Valerio, Fry, Andrew E., Geis, Tobias, Andres, David Gomez, Parrini, Elena, Pogledic, Ivana, Said, Edith, Soler, Doriette, Valor, Luis M., Zaki, Maha S., Mirzaa, Ghayda, Dobyns, William B., Reiner, Orly, Guerrini, Renzo, Pilz, Daniela T., Hehr, Ute, Leventer, Richard J., Jansen, Anna C., Mancini, Grazia M. S., Di Donato, Nataliya

“…Malformations of cortical development (MCDs) are neurodevelopmental disorders that result from abnormal development of the cerebral cortex in utero. MCDs place…”
Get full text

Astrocytes as Guardians of Neuronal Excitability: Mechanisms Underlying Epileptogenesis by Verhoog, Quirijn P, Holtman, Linda, Aronica, Eleonora, van Vliet, Erwin A

“…Astrocytes are key homeostatic regulators in the central nervous system and play important roles in physiology. After brain damage caused by e.g., status…”
Get full text

A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors by Blumcke, Ingmar, Aronica, Eleonora, Urbach, Horst, Alexopoulos, Andreas, Gonzalez-Martinez, Jorge A.

“…Every fourth patient submitted to epilepsy surgery suffers from a brain tumor. Microscopically, these neoplasms present with a wide-ranging spectrum of glial…”
Get full text

A novel GABAergic dysfunction in human Dravet syndrome by Ruffolo, Gabriele, Cifelli, Pierangelo, Roseti, Cristina, Thom, Maria, van Vliet, Erwin A., Limatola, Cristina, Aronica, Eleonora, Palma, Eleonora

“…Summary Objective Dravet syndrome is a rare neurodevelopmental disease, characterized by general cognitive impairment and severe refractory seizures. The…”
Get full text

Glia as a source of cytokines: Implications for neuronal excitability and survival by Vezzani, Annamaria, Ravizza, Teresa, Balosso, Silvia, Aronica, Eleonora

“…Summary In the last decade, preclinical studies have provided a better characterization of the homeostatic and maladaptive mechanisms occurring either during…”
Get full text

GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis by Roseti, Cristina, van Vliet, Erwin A, Cifelli, Pierangelo, Ruffolo, Gabriele, Baayen, Johannes C, Di Castro, Maria Amalia, Bertollini, Cristina, Limatola, Cristina, Aronica, Eleonora, Vezzani, Annamaria, Palma, Eleonora

“…Abstract Temporal lobe epilepsy (TLE) is the most prevalent form of adult focal onset epilepsy often associated with drug-resistant seizures. Numerous studies…”
Get full text

Precise detection of low-level somatic mutation in resected epilepsy brain tissue by Sim, Nam Suk, Ko, Ara, Kim, Woo Kyeong, Kim, Se Hoon, Kim, Ju Seong, Shim, Kyu-Won, Aronica, Eleonora, Mijnsbergen, Caroline, Spliet, Wim G. M., Koh, Hyun Yong, Kim, Heung Dong, Lee, Joon Soo, Kim, Dong Seok, Kang, Hoon-Chul, Lee, Jeong Ho

“…Low-level somatic mutations have been shown to be the major genetic etiology of intractable epilepsy. The extents thereof, however, have yet to be…”
Get full text

Neuroinflammatory targets and treatments for epilepsy validated in experimental models by Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaufer, Daniela, Koh, Sookyong, Löscher, Wolfgang, Louboutin, Jean‐Pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria, Kaminski, Rafal M.

“…Summary A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy…”
Get full text