Search Results - "Aron, B"

Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling by Fisher, Aron B.

“…Peroxiredoxin 6 represents a widely distributed group of peroxiredoxins that contain a single conserved cysteine in the protein monomer (1-cys Prdx). The cys…”
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The phospholipase A2 activity of peroxiredoxin 6 [S] by Fisher, Aron B.

“…Peroxiredoxin 6 (Prdx6) is a Ca2+-independent intracellular phospholipase A2 (called aiPLA2) that is localized to cytosol, lysosomes, and lysosomal-related…”
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Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase A₂ activities by Fisher, Aron B

“…Peroxiredoxin 6 (Prdx6) is the prototype and the only mammalian 1-Cys member of the Prdx family. Major differences from 2-Cys Prdxs include the use of…”
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A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte by Plasschaert, Lindsey W., Žilionis, Rapolas, Choo-Wing, Rayman, Savova, Virginia, Knehr, Judith, Roma, Guglielmo, Klein, Allon M., Jaffe, Aron B.

“…The functions of epithelial tissues are dictated by the types, abundance and distribution of the differentiated cells they contain. Attempts to restore tissue…”
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Redox signaling across cell membranes by Fisher, Aron B

“…Generation of reactive oxygen species (ROS) by plasma membrane-localized NADPH oxidase (Nox 2) is a major mechanism of cell signaling associated with…”
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Rho GTPases: biochemistry and biology by Jaffe, Aron B, Hall, Alan

“…Approximately one percent of the human genome encodes proteins that either regulate or are regulated by direct interaction with members of the Rho family of…”
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Mechanotransduction in the endothelium: role of membrane proteins and reactive oxygen species in sensing, transduction, and transmission of the signal with altered blood flow by Chatterjee, Shampa, Fisher, Aron B

“…Changes in shear stress associated with alterations in blood flow initiate a signaling cascade that modulates the vascular phenotype. Shear stress is "sensed"…”
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Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis by Jaffe, Aron B, Kaji, Noriko, Durgan, Joanne, Hall, Alan

“…The establishment of apical-basal polarity within a single cell and throughout a growing tissue is a key feature of epithelial morphogenesis. To examine the…”
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Structural and Functional Diversity of the Peroxiredoxin 6 Enzyme Family by Rahaman, Hamidur, Herojit, Khundrakpam, Singh, Laishram Rajendrakumar, Haobam, Reena, Fisher, Aron B

“…Peroxiredoxins (Prdxs) with a single peroxidative cysteine (C ) in a conserved motif PXXX(T/S)XXC within its thioredoxin fold, have been classified as the…”
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Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung by Danahay, Henry, Pessotti, Angelica D., Coote, Julie, Montgomery, Brooke E., Xia, Donghui, Wilson, Aaron, Yang, Haidi, Wang, Zhao, Bevan, Luke, Thomas, Chris, Petit, Stephanie, London, Anne, LeMotte, Peter, Doelemeyer, Arno, Vélez-Reyes, Germán L., Bernasconi, Paula, Fryer, Christy J., Edwards, Matt, Capodieci, Paola, Chen, Amy, Hild, Marc, Jaffe, Aron B.

“…The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. A hallmark of airway diseases is epithelial remodeling,…”
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Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation by Persson, B David, Jaffe, Aron B, Fearns, Rachel, Danahay, Henry

“…Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality worldwide, causing severe respiratory illness in infants and immune compromised…”
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Absence of Peroxiredoxin 6 Amplifies the Effect of Oxidant Stress on Mobility and SCSA/CMA3 Defined Chromatin Quality and Impairs Fertilizing Ability of Mouse Spermatozoa by Ozkosem, Burak, Feinstein, Sheldon I, Fisher, Aron B, O'Flaherty, Cristian

“…Oxidative stress, the imbalance between reactive oxygen species production and antioxidant defenses, is associated with male infertility. Peroxiredoxins…”
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A Peptide Inhibitor of NADPH Oxidase (NOX2) Activation Markedly Decreases Mouse Lung Injury and Mortality Following Administration of Lipopolysaccharide (LPS) by Fisher, Aron B, Dodia, Chandra, Chatterjee, Shampa, Feinstein, Sheldon I

“…We have previously derived three related peptides, based on a nine-amino acid sequence in human or rat/mouse surfactant protein A, that inhibit the…”
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Isolation of Mycoplasma anserisalpingitidis from swan goose (Anser cygnoides) in China by Gyuranecz, Miklós, Mitter, Alexa, Kovács, Áron B, Grózner, Dénes, Kreizinger, Zsuzsa, Bali, Krisztina, Bányai, Krisztián, Morrow, Christopher J

“…Mycoplasma anserisalpingitidis causes significant economic losses in the domestic goose (Anser anser) industry in Europe. As 95% of the global goose production…”
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Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma by Zhan, Lixing, Rosenberg, Avi, Bergami, Kenneth C., Yu, Min, Xuan, Zhenyu, Jaffe, Aron B., Allred, Craig, Muthuswamy, Senthil K.

“…Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. In mammals, the role that polarity…”
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Mechanotransduction: forces, sensors, and redox signaling by Chatterjee, Shampa, Fisher, Aron B

“…Mechanotransduction describes the molecular mechanisms by which cells response to changes in their physical environment by translating mechanical stimuli into…”
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Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells by Francis, Víctor A, Abera, Aron B, Matjila, Mushi, Millar, Robert P, Katz, Arieh A

“…The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to…”
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Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice by Ozkosem, Burak, Feinstein, Sheldon I, Fisher, Aron B, O'Flaherty, Cristian

“…Due to socioeconomic factors, more couples are choosing to delay conception than ever. Increasing average maternal and paternal age in developed countries over…”
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Shear stress-related mechanosignaling with lung ischemia: lessons from basic research can inform lung transplantation by Chatterjee, Shampa, Nieman, Gary F, Christie, Jason D, Fisher, Aron B

“…Cessation of blood flow represents a physical event that is sensed by the pulmonary endothelium leading to a signaling cascade that has been termed…”
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Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes by Fisher, Aron B., Vasquez-Medina, Jose P., Dodia, Chandra, Sorokina, Elena M., Tao, Jian-Qin, Feinstein, Sheldon I.

“…Although lipid peroxidation associated with oxidative stress can result in cellular death, sub-lethal lipid peroxidation can gradually resolve with return to…”
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