Search Results - "Aro, Jani"

(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function by Moilanen, Anne-Mari, Rysä, Jaana, Serpi, Raisa, Mustonen, Erja, Szabò, Zoltán, Aro, Jani, Näpänkangas, Juha, Tenhunen, Olli, Sutinen, Meeri, Salo, Tuula, Ruskoaho, Heikki

“…Activation of the renin-angiotensin-system (RAS) plays a key pathophysiological role in heart failure in patients with hypertension and myocardial infarction…”
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Characterization of the regulatory mechanisms of activating transcription factor 3 by hypertrophic stimuli in rat cardiomyocytes by Koivisto, Elina, Jurado Acosta, Alicia, Moilanen, Anne-Mari, Tokola, Heikki, Aro, Jani, Pennanen, Harri, Säkkinen, Hanna, Kaikkonen, Leena, Ruskoaho, Heikki, Rysä, Jaana

“…Activating transcription factor 3 (ATF3) is a stress-activated immediate early gene suggested to have both detrimental and cardioprotective role in the heart…”
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Thrombospondin-4 expression is rapidly upregulated by cardiac overload by Mustonen, Erja, Aro, Jani, Puhakka, Jutta, Ilves, Mika, Soini, Ylermi, Leskinen, Hanna, Ruskoaho, Heikki, Rysä, Jaana

“…The precise mechanisms regulating gene expression of thrombospondins (TSPs) in the heart remain incompletely understood. Here we characterized cardiac TSP-4…”
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Bone morphogenetic protein-2 − A potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes by Tokola, Heikki, Rysä, Jaana, Pikkarainen, Sampsa, Hautala, Nina, Leskinen, Hanna, Kerkelä, Risto, Ilves, Mika, Aro, Jani, Vuolteenaho, Olli, Ritvos, Olli, Ruskoaho, Heikki

“…•Mechanical stretch of cultured cardiomyocytes in vitro and in vivo acute or chronic pressure overload, induced by arginine vasopressin or angiotensin II…”
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Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms by Koivisto, Elina, Kaikkonen, Leena, Tokola, Heikki, Pikkarainen, Sampsa, Aro, Jani, Pennanen, Harri, Karvonen, Teemu, Rysä, Jaana, Kerkelä, Risto, Ruskoaho, Heikki

“…► We demonstrate distinct cardiac gene regulation by p38α and p38β. ► p38α induces BNP transcription through AP-1 and p38β through GATA-4. ► p38β is the main…”
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M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation by Koivisto, Elina, Karkkola, Laura, Majalahti, Theresa, Aro, Jani, Tokola, Heikki, Kerkelä, Risto, Ruskoaho, Heikki

“…The muscle-CAT (M-CAT) promoter element is found on promoters of most muscle-specific cardiac genes, but its role in cardiac pathology is poorly understood…”
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Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2‑5 by Välimäki, Mika J, Tölli, Marja A, Kinnunen, Sini M, Aro, Jani, Serpi, Raisa, Pohjolainen, Lotta, Talman, Virpi, Poso, Antti, Ruskoaho, Heikki J

“…Transcription factors are pivotal regulators of gene transcription, and many diseases are associated with the deregulation of transcriptional networks. In the…”
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Abstract 297: Cardiac Transforming-growth-factor β-stimulated Clone 22 Gene Expression By Hypertrophic Stimuli by Kelloniemi, Annina, Aro, Jani, Koivisto, Elina, Ruskoaho, Heikki, Rysä, Jaana

“…Abstract only Objectives: Transforming-growth-factor β-stimulated clone 22 (TSC-22) is a leucine zipper protein expressed in many tissues and possessing…”
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Increased thrombospondin-2 in human fibrosclerotic and stenotic aortic valves by Pohjolainen, Virva, Mustonen, Erja, Taskinen, Panu, Näpänkangas, Juha, Leskinen, Hanna, Ohukainen, Pauli, Peltonen, Tuomas, Aro, Jani, Juvonen, Tatu, Satta, Jari, Ruskoaho, Heikki, Rysä, Jaana

“…Abstract Background Active involvement of extracellular matrix (ECM) and its composition regulating factors may have a central role in the pathogenesis of…”
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Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity by Skoumal, Réka, Tóth, Miklós, Serpi, Raisa, Rysä, Jaana, Leskinen, Hanna, Ulvila, Johanna, Saiho, Tarja, Aro, Jani, Ruskoaho, Heikki, Szokodi, István, Kerkelä, Risto

“…Abstract Parthenolide has shown promise in treatment of various cancers via inhibition of the transcription factor signal transducer and activator of…”
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p38α regulates SERCA2a function by Kaikkonen, Leena, Magga, Johanna, Ronkainen, Veli-Pekka, Koivisto, Elina, Perjes, Ábel, Chuprun, J. Kurt, Vinge, Leif Erik, Kilpiö, Teemu, Aro, Jani, Ulvila, Johanna, Alakoski, Tarja, Bibb, James A, Szokodi, Istvan, Koch, Walter J, Ruskoaho, Heikki, Kerkelä, Risto

“…Abstract cAMP-dependent protein kinase (PKA) regulates the L-type calcium channel, the ryanodine receptor, and phospholamban (PLB) thereby increasing inotropy…”
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Intramyocardial BNP gene delivery improves cardiac function through distinct context-dependent mechanisms by Moilanen, Anne-Mari, Rysä, Jaana, Mustonen, Erja, Serpi, Raisa, Aro, Jani, Tokola, Heikki, Leskinen, Hanna, Manninen, Aki, Levijoki, Jouko, Vuolteenaho, Olli, Ruskoaho, Heikki

“…B-type natriuretic peptide (BNP) is an endogenous peptide produced under physiological and pathological conditions mainly by ventricular myocytes. It has…”
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(Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis by Peltonen, Tuomas, Näpänkangas, Juha, Ohtonen, Pasi, Aro, Jani, Peltonen, Jenni, Soini, Ylermi, Juvonen, Tatu, Satta, Jari, Ruskoaho, Heikki, Taskinen, Panu

“…Abstract Background There is increasing evidence that renin–angiotensin system (RAS) may play a major role in the actively regulated fibrocalcific process in…”
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TSC-22 up-regulates collagen 3a1 gene expression in the rat heart by Kelloniemi, Annina, Aro, Jani, Näpänkangas, Juha, Koivisto, Elina, Mustonen, Erja, Ruskoaho, Heikki, Rysä, Jaana

“…The transforming growth factor (TGF)-β is one of the key mediators in cardiac remodelling occurring after myocardial infarction (MI) and in hypertensive heart…”
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Abstract 163: Inhibition of p38a Regulates SERCA2a Function by Kaikkonen, Leena, Magga, Johanna, Ronkainen, Veli-Pekka, Koivisto, Elina, Perjes, ábel, Chuprun, Kurt, Vinge, Leif E, Aro, Jani, Ulvila, Johanna, Alakoski, Tarja, Bibb, James, Szokodi, Istvan, Koch, Walter J, Ruskoaho, Heikki, Kerkelä, Risto

“…Abstract only Rationale: p38 MAPK is a negative regulator of cardiac contractile function, but the underlying molecular mechanism is not well understood…”
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Mitogen‐activated protein kinase p38 target regenerating islet‐derived 3γ expression is upregulated in cardiac inflammatory response in the rat heart by Säkkinen, Hanna, Aro, Jani, Kaikkonen, Leena, Ohukainen, Pauli, Näpänkangas, Juha, Tokola, Heikki, Ruskoaho, Heikki, Rysä, Jaana

“…Regenerating islet‐derived 3γ (Reg3γ) is a multifunctional protein, associated with various tissue injuries and inflammatory states. Since chronic inflammation…”
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Metoprolol Treatment Lowers Thrombospondin‐4 Expression in Rats with Myocardial Infarction and Left Ventricular Hypertrophy by Mustonen, Erja, Leskinen, Hanna, Aro, Jani, Luodonpää, Marja, Vuolteenaho, Olli, Ruskoaho, Heikki, Rysä, Jaana

“…:  Thrombospondins are matrix proteins linked to extracellular matrix remodelling but their precise role in the heart is not known. In this study, we…”
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Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli by Mustonen, Erja, Pohjolainen, Virva, Aro, Jani, Pikkarainen, Sampsa, Leskinen, Hanna, Ruskoaho, Heikki, Rysä, Jaana

“…Matrix Gla protein (MGP) expression is increased in cardiac hypertrophy, but the precise mechanisms regulating its expression are unknown. Here we…”
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Characterization of the Regulatory Mechanisms of Activating Transcription Factor 3 by Hypertrophic Stimuli in Rat Cardiomyocytes: e105168 by Koivisto, Elina, Acosta, Alicia Jurado, Moilanen, Anne-Mari, Tokola, Heikki, Aro, Jani, Pennanen, Harri, Saekkinen, Hanna, Kaikkonen, Leena, Ruskoaho, Heikki, Rysae, Jaana

“…Aims Activating transcription factor 3 (ATF3) is a stress-activated immediate early gene suggested to have both detrimental and cardioprotective role in the…”
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Early left ventricular gene expression profile in response to increase in blood pressure by Rysä, Jaana, Aro, Jani, Ruskoaho, Heikki

“…The heart adapts to increased pressure overload by hypertrophic growth of terminally differentiated cardiomyocytes. At the genetic level, the hypertrophic…”
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