Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor

Pediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chem...

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Bibliographic Details
Published in:	Journal of neurosurgery. Pediatrics Vol. 20; no. 1; pp. 51 - 55
Main Authors:	Kiehna, Erin N, Arnush, Maxine R, Tamrazi, Benita, Cotter, Jennifer A, Hawes, Debra, Robison, Nathan J, Fong, Cindy Y, Estrine, Dolores B, Han, Jennifer H, Biegel, Jaclyn A
Format:	Journal Article
Language:	English
Published:	United States 01-07-2017
Subjects:	Brain - diagnostic imaging Brain - pathology Brain - surgery Brain Neoplasms - diagnostic imaging Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - surgery Carrier Proteins - genetics Child, Preschool Female Glioma - diagnostic imaging Glioma - genetics Glioma - pathology Glioma - surgery Humans Membrane Proteins - genetics Neoplasm Grading Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics Sequence Deletion Survivors receptor protein-tyrosine kinases CNS = central nervous system FFPE = formalin-fixed, paraffin-embedded RT-PCR = reverse transcriptase–polymerase chain reaction 6q22 deletion GOPC RTK = receptor tyrosine kinase ROS1 oncology
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Summary:	Pediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chemotherapy and autologous hematopoietic stem cell rescue. At 30 months after transplantation, she remains disease free.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1933-0707 1933-0715
DOI:	10.3171/2017.2.peds16679