Search Results - "Arnot, Jon A"

Addressing uncertainty in mouthing-mediated ingestion of chemicals on indoor surfaces, objects, and dust by Li, Li, Hughes, Lauren, Arnot, Jon A.

“…•Mouthing-mediated chemical ingestion is explored using a novel mechanistic model.•Chemicals found in hand wipes are mainly from dust transfer, whereas those…”
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Application of Mass Balance Models and the Chemical Activity Concept To Facilitate the Use of in Vitro Toxicity Data for Risk Assessment by Armitage, James M, Wania, Frank, Arnot, Jon A

“…Practical, financial, and ethical considerations related to conducting extensive animal testing have resulted in various initiatives to promote and expand the…”
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Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish by Armitage, James M., Arnot, Jon A., Wania, Frank, Mackay, Don

“…A mechanistic mass balance bioconcentration model is developed and parameterized for ionogenic organic chemicals (IOCs) in fish and evaluated against a…”
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Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities by Armitage, James M., Erickson, Russell J., Luckenbach, Till, Ng, Carla A., Prosser, Ryan S., Arnot, Jon A., Schirmer, Kristin, Nichols, John W.

“…The objective of the present study was to review the current knowledge regarding the bioaccumulation potential of ionizable organic compounds (IOCs), with a…”
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A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms by Arnot, Jon A, Gobas, Frank APC

“…Bioaccumulation assessment is important in the scientific evaluation of risks that chemicals may pose to humans and the environment and is a current focus of…”
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Development and intercomparison of single and multicompartment physiologically-based toxicokinetic models: Implications for model selection and tiered modeling frameworks by Armitage, James M., Hughes, Lauren, Sangion, Alessandro, Arnot, Jon A.

“…•Study provides explicit guidance on model selection for key exposure scenarios.•Simple toxicokinetic models can be applied to simulate exposure in many…”
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Dechlorane Plus and Related Compounds in the Environment: A Review by Sverko, Ed, Tomy, Gregg T, Reiner, Eric J, Li, Yi-Fan, McCarry, Brian E, Arnot, Jon A, Law, Robin J, Hites, Ronald A

“…Dechlorane Plus (DP) is a high production volume, chlorinated flame retardant. Despite its long production history, it was only recently found in the…”
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Metabolic biotransformation half-lives in fish: QSAR modeling and consensus analysis by Papa, Ester, van der Wal, Leon, Arnot, Jon A., Gramatica, Paola

“…Bioaccumulation in fish is a function of competing rates of chemical uptake and elimination. For hydrophobic organic chemicals bioconcentration,…”
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Development of human biotransformation QSARs and application for PBT assessment refinement by Papa, Ester, Sangion, Alessandro, Arnot, Jon A., Gramatica, Paola

“…Toxicokinetics heavily influence chemical toxicity as the result of Absorption, Distribution, Metabolism (Biotransformation) and Elimination (ADME) processes…”
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Examining Uncertainty in In Vitro–In Vivo Extrapolation Applied in Fish Bioconcentration Models by Laue, Heike, Hostettler, Lu, Badertscher, Remo P, Jenner, Karen J, Sanders, Gordon, Arnot, Jon A, Natsch, Andreas

“…In vitro biotransformation rates were determined for 30 chemicals, mostly fragrance ingredients, using trout liver S9 fractions (RT-S9) and incorporated into…”
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Development and Evaluation of a Database of Dietary Bioaccumulation Test Data for Organic Chemicals in Fish by Arnot, Jon A, Quinn, Cristina L

“…Dietary bioaccumulation tests for fish have been conducted for about 40 years. Standardized test guidance has recently been developed. Test metrics of primary…”
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A Model for Risk-Based Screening and Prioritization of Human Exposure to Chemicals from Near-Field Sources by Li, Li, Westgate, John N, Hughes, Lauren, Zhang, Xianming, Givehchi, Babak, Toose, Liisa, Armitage, James M, Wania, Frank, Egeghy, Peter, Arnot, Jon A

“…Exposure- and risk-based assessments for chemicals used indoors or applied to humans (i.e., in near-field environments) necessitate an aggregate exposure…”
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Iterative Fragment Selection: A Group Contribution Approach to Predicting Fish Biotransformation Half-Lives by Brown, Trevor N, Arnot, Jon A, Wania, Frank

“…There are regulatory needs to evaluate thousands of chemicals for potential hazard and risk with limited available information. An automated method is…”
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Identifying uncertainty in physical–chemical property estimation with IFSQSAR by Brown, Trevor N., Sangion, Alessandro, Arnot, Jon A.

“…This study describes the development and evaluation of six new models for predicting physical–chemical (PC) properties that are highly relevant for chemical…”
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Toward improved models for predicting bioconcentration of well-metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance by Nichols, John W., Huggett, Duane B., Arnot, Jon A., Fitzsimmons, Patrick N., Cowan-Ellsberry, Christina E.

“…Models were developed to predict the bioconcentration of well‐metabolized chemicals by rainbow trout. The models employ intrinsic clearance data from in vitro…”
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Characterization of age-based trends to identify chemical biomarkers of higher levels in children by Nguyen, Vy Kim, Colacino, Justin A., Arnot, Jon A., Kvasnicka, Jacob, Jolliet, Olivier

“…Chemical biomarker concentrations are driven by complex interactions between chemical use patterns, exposure pathways, and toxicokinetic parameters such as…”
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Risk-Based High-Throughput Chemical Screening and Prioritization using Exposure Models and in Vitro Bioactivity Assays by Shin, Hyeong-Moo, Ernstoff, Alexi, Arnot, Jon A., Wetmore, Barbara A., Csiszar, Susan A., Fantke, Peter, Zhang, Xianming, McKone, Thomas E., Jolliet, Olivier, Bennett, Deborah H.

“…We present a risk-based high-throughput screening (HTS) method to identify chemicals for potential health concerns or for which additional information is…”
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A food web bioaccumulation model for organic chemicals in aquatic ecosystems by Arnot, Jon A., Gobas, Frank A. P. C.

“…The present study examines a new bioaccumulation model for hydrophobic organic chemicals in aquatic food webs. The purpose of the model is to provide…”
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A framework for understanding the bioconcentration of surfactants in fish by McLachlan, Michael S, Ebert, Andrea, Armitage, James M, Arnot, Jon A, Droge, Steven T J

“…Surfactants are a class of chemicals released in large quantities to water, and therefore bioconcentration in fish is an important component of their safety…”
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Estimating metabolic biotransformation rates in fish from laboratory data by Arnot, Jon A., Mackay, Don, Bonnell, Mark

“…A method is proposed for estimating metabolic biotransformation rate constants for nonionic organic chemicals from measured laboratory bioconcentration and…”
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