Search Results - "Arnot, Christopher J."

Cytokine Spätzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation by Lewis, Miranda, Arnot, Christopher J., Beeston, Helen, McCoy, Airlie, Ashcroft, Alison E., Gay, Nicholas J., Gangloff, Monique

“…Drosophila Toll functions in embryonic development and innate immunity and is activated by an endogenous ligand, Spätzle (Spz). The related Toll-like receptors…”
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Functional Insights from the Crystal Structure of the N-Terminal Domain of the Prototypical Toll Receptor by Gangloff, Monique, Arnot, Christopher J., Lewis, Miranda, Gay, Nicholas J.

“…Drosophila melanogaster Toll is the founding member of an important family of pathogen-recognition receptors in humans, the Toll-like receptor (TLR) family. In…”
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An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88 by Verstak, Brett, Arnot, Christopher J, Gay, Nicholas J

“…A functionally important proline residue is highly conserved in the cytosolic Toll/IL-1R signaling domains of human TLRs. The antiviral Toll, TLR3, is unusual…”
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Molecular Mechanism That Induces Activation of Spätzle, the Ligand for the Drosophila Toll Receptor by Arnot, Christopher J., Gay, Nicholas J., Gangloff, Monique

“…The Drosophila Toll receptor is activated by an endogenous cytokine ligand Spätzle. Active ligand is generated in response to positional cues in embryonic…”
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Structural Insight into the Mechanism of Activation of the Toll Receptor by the Dimeric Ligand Spätzle by Gangloff, Monique, Murali, Ayaluru, Xiong, Jin, Arnot, Christopher J., Weber, Alexander N., Sandercock, Alan M., Robinson, Carol V., Sarisky, Robert, Holzenburg, Andreas, Kao, Cheng, Gay, Nicholas J.

“…The Drosophila Toll receptor, which functions in both embryonic patterning and innate immunity to fungi and Gram-positive bacteria, is activated by a dimeric…”
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Gene transfection of HEK cells on supermacroporous polyacrylamide monoliths: a comparison of transient and stable recombinant protein expression in perfusion culture by Cheeks, Matthew C., Edwards, Alexander D., Arnot, Christopher J., Slater, Nigel K.H.

“…Transient and continuous recombinant protein expression by HEK cells was evaluated in a perfused monolithic bioreactor. Highly porous synthetic cryogel…”
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An alanine to proline mutation in the BB-loop of Toll-like receptor 3 TIR domain switches signalling adaptor specificity from TRIF to MyD88 by Verstak, Brett, Arnot, Christopher J., Gay, Nicholas J.

“…A functionally important proline residue is highly conserved in the cytosolic TIR signalling domains of human Toll-like receptors (TLRs). The anti-viral Toll,…”
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Cytokine Spaetzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation by Lewis, Miranda, Arnot, Christopher J, Beeston, Helen, McCoy, Airlie, Ashcroft, Alison E, Gay, Nicholas J, Gangloff, Monique

“…Drosophila Toll functions in embryonic development and innate immunity and is activated by an endogenous ligand, Spatzle (Spz). The related Toll-like receptors…”
Get full text

Molecular Mechanism That Induces Activation of Spaatzle, the Ligand for the Drosophila Toll Receptor by Arnot, Christopher J, Gay, Nicholas J, Gangloff, Monique

“…The Drosophila Toll receptor is activated by an endogenous cytokine ligand Spaatzle. Active ligand is generated in response to positional cues in embryonic…”
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Structural Insight into the Mechanism of Activation of the Toll Receptor by the Dimeric Ligand Spätzle by Monique Gangloff, Ayaluru Murali, Jin Xiong, Christopher J. Arnot, Alexander N. Weber, Alan M. Sandercock, Carol V. Robinson, Robert Sarisky, Andreas Holzenburg, Cheng Kao, Nicholas J. Gay

“…The Drosophila Toll receptor, which functions in both embryonic patterning and innate immunity to fungi and Gram-positive bacteria, is activated by a dimeric…”
Get full text

Structural Insight into the Mechanism of Activation of the Toll Receptor by the Dimeric Ligand Spaetzle by Gangloff, Monique, Murali, Ayaluru, Xiong, Jin, Arnot, Christopher J, Weber, Alexander N, Sandercock, Alan M, Robinson, Carol V, Sarisky, Robert, Holzenburg, Andreas, Kao, Cheng, Gay, Nicholas J

“…The Drosophila Toll receptor, which functions in both embryonic patterning and innate immunity to fungi and Gram-positive bacteria, is activated by a dimeric…”
Get full text