Search Results - "Arnon, Ruth"

Astrocytes in Multiple Sclerosis—Essential Constituents with Diverse Multifaceted Functions by Aharoni, Rina, Eilam, Raya, Arnon, Ruth

“…In multiple sclerosis (MS), astrocytes respond to the inflammatory stimulation with an early robust process of morphological, transcriptional, biochemical, and…”
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Amyloid Precursor Protein and Tau Peptides Linked Together Ameliorate Loss of Cognition in an Alzheimer's Disease Animal Model by Maron, Ruth, Vinik, Yaron, Tsoory, Michael, Wilchek, Meir, Arnon, Ruth

“…The major proteins involved in Alzheimer's disease (AD) are amyloid precursor protein (APP) and Tau. We demonstrate that APP1 (390-412) and Tau1 (19-34),…”
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Astrocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis by Eilam, Raya, Segal, Menahem, Malach, Rafael, Sela, Michael, Arnon, Ruth, Aharoni, Rina

“…To elucidate mechanisms contributing to cortical pathology in multiple sclerosis (MS), we investigated neurovascular aberrations, in particular the association…”
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Neuroprotective Effect of Glatiramer Acetate on Neurofilament Light Chain Leakage and Glutamate Excess in an Animal Model of Multiple Sclerosis by Aharoni, Rina, Eilam, Raya, Lerner, Shaul, Shavit-Stein, Efrat, Dori, Amir, Chapman, Joab, Arnon, Ruth

“…Axonal and neuronal pathologies are a central constituent of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE),…”
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Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration by Maron, Ruth, Armony, Gad, Tsoory, Michael, Wilchek, Meir, Frenkel, Dan, Arnon, Ruth

“…The two major proteins involved in Alzheimer's disease (AD) are the amyloid precursor protein (APP) and Tau. Here, we demonstrate that these two proteins can…”
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Mechanism of Action of Glatiramer Acetate in Multiple Sclerosis and Its Potential for the Development of New Applications by Arnon, Ruth, Aharoni, Rina

“…Glatiramer acetate (GA, Copaxone, Copolymer 1) is an approved drug for the treatment of multiple sclerosis and is highly effective in the suppression of…”
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Neuroprotection and neurogeneration in MS and its animal model EAE effected by glatiramer acetate by Arnon, Ruth, Aharoni, Rina

“…It is by now established that multiple sclerosis (MS) is not simply an autoimmune disease and that in addition to inflammation and demyelination, axonal injury…”
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Chromatin conformation governs T-cell receptor Jβ gene segment usage by Ndifon, Wilfred, Gal, Hilah, Shifrut, Eric, Aharoni, Rina, Yissachar, Nissan, Waysbort, Nir, Reich-Zeliger, Shlomit, Arnon, Ruth, Friedman, Nir

“…T cells play fundamental roles in adaptive immunity, relying on a diverse repertoire of T-cell receptor (TCR) α and β chains. Diversity of the TCR β chain is…”
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Astrocyte morphology is confined by cortical functional boundaries in mammals ranging from mice to human by Eilam, Raya, Aharoni, Rina, Arnon, Ruth, Malach, Rafael

“…Cortical blood flow can be modulated by local activity across a range of species; from barrel-specific blood flow in the rodent somatosensory cortex to the…”
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Distinct pathological patterns in relapsing–remitting and chronic models of experimental autoimmune enchephalomyelitis and the neuroprotective effect of glatiramer acetate by Aharoni, Rina, Vainshtein, Anya, Stock, Ariel, Eilam, Raya, From, Renana, Shinder, Vera, Arnon, Ruth

“…Abstract The respective roles of inflammatory and neurodegenerative processes in the pathology of multiple sclerosis (MS) and in its animal model experimental…”
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Neurogenesis and Neuroprotection Induced by Peripheral Immunomodulatory Treatment of Experimental Autoimmune Encephalomyelitis by Aharoni, Rina, Arnon, Ruth, Eilam, Raya

“…Brain insults such as the autoimmune inflammatory process in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) induce a measure of…”
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The Immunomodulator Glatiramer Acetate Augments the Expression of Neurotrophic Factors in Brains of Experimental Autoimmune Encephalomyelitis Mice by Aharoni, Rina, Eilam, Raya, Hagit Domev, Galya Labunskay, Sela, Michael, Arnon, Ruth

“…Neurotrophins (NTs) such as BDNF, NT-3, and NT-4 are important modulators of neuronal function and survival. Their expression in the CNS after various insults…”
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Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis by Aharoni, Rina, Herschkovitz, Avia, Eilam, Raya, Blumberg-Hazan, Michal, Sela, Michael, Bruck, Wolfgang, Arnon, Ruth

“…The interplay between demyelination and remyelination is critical in the progress of multiple sclerosis (MS) and its animal model, experimental autoimmune…”
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Magnetic resonance imaging characterization of different experimental autoimmune encephalomyelitis models and the therapeutic effect of glatiramer acetate by Aharoni, Rina, Sasson, Efrat, Blumenfeld-Katzir, Tamar, Eilam, Raya, Sela, Michael, Assaf, Yaniv, Arnon, Ruth

“…The roles of inflammation and degeneration as well as of gray matter abnormalities in multiple sclerosis (MS) and its animal model experimental autoimmune…”
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Glatiramer Acetate-Specific T Cells in the Brain Express T Helper 2/3 Cytokines and Brain-Derived Neurotrophic Factor in situ by Aharoni, Rina, Kayhan, Basak, Eilam, Raya, Sela, Michael, Arnon, Ruth

“…The ability of a remedy to modulate the pathological process in the target organ is crucial for its therapeutic activity. Glatiramer acetate (GA, Copaxone,…”
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A DNA Aptamer Prevents Influenza Infection by Blocking the Receptor Binding Region of the Viral Hemagglutinin by Jeon, Sung Ho, Kayhan, Basak, Ben-Yedidia, Tamar, Arnon, Ruth

“…Influenza A virus infection is a major source of morbidity and mortality worldwide. Current means of control for influenza are based on prophylaxis by vaccines…”
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Neurogenesis and neuroprotection in the CNS--fundamental elements in the effect of Glatiramer acetate on treatment of autoimmune neurological disorders by Arnon, Ruth, Aharoni, Rina

“…Multiple sclerosis (MS) is no longer considered to be simply an autoimmune disease. In addition to inflammation and demyelination, axonal injury and neuronal…”
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Role of Helical Structure in MBP Immunodominant Peptides for Efficient IgM Antibody Recognition in Multiple Sclerosis by Staśkiewicz, Agnieszka, Quagliata, Michael, Real-Fernandez, Feliciana, Nuti, Francesca, Lanzillo, Roberta, Brescia-Morra, Vincenzo, Rusche, Hendrik, Jewginski, Michal, Carotenuto, Alfonso, Brancaccio, Diego, Aharoni, Rina, Arnon, Ruth, Rovero, Paolo, Latajka, Rafal, Papini, Anna Maria

“…The involvement of Myelin Basic Protein (MBP) in Multiple Sclerosis (MS) has been widely discussed in the literature. This intrinsically disordered protein has…”
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Specific Th2 Cells Accumulate in the Central Nervous System to Mice Protected against Experimental Autoimmune Encephalomyelitis by Copolymer 1 by Aharoni, Rina, Teitelbaum, Dvora, Leitner, Orith, Meshorer, Asher, Sela, Michael, Arnon, Ruth

“…This study addresses the issue of the effect of immunomodulating therapies in the target organ--the central nervous system (CNS)--in the case of multiple…”
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Immunomodulatory therapeutic effect of glatiramer acetate on several murine models of inflammatory bowel disease by Aharoni, Rina, Kayhan, Basak, Brenner, Ori, Domev, Hagit, Labunskay, Galya, Arnon, Ruth

“…Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut and imbalance between proinflammatory and anti-inflammatory…”
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