Search Results - "Arnold, R."

The use of brain organoids to investigate neural development and disease by Di Lullo, Elizabeth, Kriegstein, Arnold R.

“…Key Points Organoid models provide an opportunity to model the unique features of human brain development in a complex tissue-like environment. The intrinsic…”
Get full text

Single-cell genomics identifies cell type-specific molecular changes in autism by Velmeshev, Dmitry, Schirmer, Lucas, Jung, Diane, Haeussler, Maximilian, Perez, Yonatan, Mayer, Simone, Bhaduri, Aparna, Goyal, Nitasha, Rowitch, David H, Kriegstein, Arnold R

“…Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show that changes in the neocortex of autism patients converge on common…”
Get full text

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia by Eze, Ugomma C., Bhaduri, Aparna, Haeussler, Maximilian, Nowakowski, Tomasz J., Kriegstein, Arnold R.

“…The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of…”
Get full text

Development and Evolution of the Human Neocortex by Lui, Jan H., Hansen, David V., Kriegstein, Arnold R.

“…The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the…”
Get full text

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells by Nowakowski, Tomasz J., Pollen, Alex A., Di Lullo, Elizabeth, Sandoval-Espinosa, Carmen, Bershteyn, Marina, Kriegstein, Arnold R.

“…The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microcephaly. However, information about…”
Get full text

Environmental, Metabolic, and Nutritional Factors Concerning Dementia in African American and Hispanic American Populations by Eiser, Arnold R.

“…•African Americans experience more severe vitamin D deficiency and magnesium deficiency that together may promote dementia.•Hispanic Americans experience more…”
Get full text

Environmental Neurotoxins and a Neurodegenerative Outbreak: Diagnosis Requires Specific Sampling Knowledge by Eiser, Arnold R.

Get full text

Mild Cognitive Impairment and the Missed Opportunity to Prevent Dementia by Eiser, Arnold R.

Get full text

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development by Nowakowski, Tomasz J., Pollen, Alex A., Sandoval-Espinosa, Carmen, Kriegstein, Arnold R.

“…The classic view of cortical development, embodied in the radial unit hypothesis, highlights the ventricular radial glia (vRG) scaffold as a key architectonic…”
Get full text

Challenges of Organoid Research by Andrews, Madeline G, Kriegstein, Arnold R

“…Organoids are 3D cell culture systems derived from human pluripotent stem cells that contain tissue resident cell types and reflect features of early tissue…”
Get full text

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex by Nowakowski, Tomasz J., Bhaduri, Aparna, Pollen, Alex A., Alvarado, Beatriz, Mostajo-Radji, Mohammed A., Di Lullo, Elizabeth, Haeussler, Maximilian, Sandoval-Espinosa, Carmen, Liu, Siyuan John, Velmeshev, Dmitry, Ounadjela, Johain Ryad, Shuga, Joe, Wang, Xiaohui, Lim, Daniel A., West, Jay A., Leyrat, Anne A., Kent, W. James, Kriegstein, Arnold R.

“…Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell types at different stages of…”
Get full text

Molecular Identity of Human Outer Radial Glia during Cortical Development by Pollen, Alex A., Nowakowski, Tomasz J., Chen, Jiadong, Retallack, Hanna, Sandoval-Espinosa, Carmen, Nicholas, Cory R., Shuga, Joe, Liu, Siyuan John, Oldham, Michael C., Diaz, Aaron, Lim, Daniel A., Leyrat, Anne A., West, Jay A., Kriegstein, Arnold R.

“…Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. Although outer…”
Get full text

A GABAergic projection from the zona incerta to cortex promotes cortical neuron development by Chen, Jiadong, Kriegstein, Arnold R.

“…γ-Aminobutyric acid (GABA) is the major inhibitory transmitter in the mature brain but is excitatory in the developing cortex. We found that mouse zona incerta…”
Get full text

The Current State of Pharma and the FDA: Approval of a Dementia Drug as a Case in Point by Eiser, Arnold R.

Get full text

A new subtype of progenitor cell in the mouse embryonic neocortex by Wang, Xiaoqun, Kriegstein, Arnold R, Tsai, Jin-Wu, LaMonica, Bridget

“…The authors report that radial glia–like (oRG) progenitor cells are present in the mouse embryonic cortex and that these cells arise from asymmetric divisions…”
Get full text

The Long Noncoding RNA Pnky Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells by Ramos, Alexander D., Andersen, Rebecca E., Liu, Siyuan John, Nowakowski, Tomasz Jan, Hong, Sung Jun, Gertz, Caitlyn C., Salinas, Ryan D., Zarabi, Hosniya, Kriegstein, Arnold R., Lim, Daniel A.

“…While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify…”
Get full text

Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia by Bershteyn, Marina, Nowakowski, Tomasz J., Pollen, Alex A., Di Lullo, Elizabeth, Nene, Aishwarya, Wynshaw-Boris, Anthony, Kriegstein, Arnold R.

“…Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the…”
Get full text

Origins and Proliferative States of Human Oligodendrocyte Precursor Cells by Huang, Wei, Bhaduri, Aparna, Velmeshev, Dmitry, Wang, Shaohui, Wang, Li, Rottkamp, Catherine A., Alvarez-Buylla, Arturo, Rowitch, David H., Kriegstein, Arnold R.

“…Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced proliferative potential…”
Get full text

A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA by Rani, Neha, Nowakowski, Tomasz J., Zhou, Hongjun, Godshalk, Sirie E., Lisi, Véronique, Kriegstein, Arnold R., Kosik, Kenneth S.

“…Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, particularly in the brain. We…”
Get full text

Photoinduced [4 + 2]-cycloaddition reactions of vinyldiazo compounds for the construction of heterocyclic and bicyclic rings by Bao, Ming, Bohórquez, Arnold R Romero, Arman, Hadi, Doyle, Michael P

“…Highly selective formal [4 + 2]-cycloaddition of vinyldiazoacetates with azoalkenes from α-halohydrazones, as well as with cyclopentadiene and furan, occurs…”
Get full text