Search Results - "Arnold, Laurence"

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction by Arnold, Laurence H, Groom, Harriet C T, Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J, Ordonez, Paula, Mann, Melanie C, Rueschenbaum, Sabrina, Goldstone, David C, Pennell, Simon, Howell, Steven A, Stoye, Jonathan P, Webb, Michelle, Taylor, Ian A, Bishop, Kate N

“…SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase…”
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Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis by Morris, Elizabeth R., Caswell, Sarah J., Kunzelmann, Simone, Arnold, Laurence H., Purkiss, Andrew G., Kelly, Geoff, Taylor, Ian A.

“…SAMHD1 regulates cellular 2′-deoxynucleoside-5′-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2′-deoxynucleosides and…”
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A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1 by Arnold, Laurence H, Kunzelmann, Simone, Webb, Martin R, Taylor, Ian A

“…The development of deoxynucleoside triphosphate (dNTP)-based drugs requires a quantitative understanding of any inhibition, activation, or hydrolysis by…”
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Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches by McIntyre, Patrick J, Collins, Patrick M, Vrzal, Lukáš, Birchall, Kristian, Arnold, Laurence H, Mpamhanga, Chido, Coombs, Peter J, Burgess, Selena G, Richards, Mark W, Winter, Anja, Veverka, Václav, Delft, Frank von, Merritt, Andy, Bayliss, Richard

“…The mitotic kinase Aurora-A and its partner protein TPX2 (Targeting Protein for Xenopus kinesin-like protein 2) are overexpressed in cancers, and it has been…”
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The Interface between Catalytic and Hemopexin Domains in Matrix Metalloproteinase-1 Conceals a Collagen Binding Exosite by Arnold, Laurence H., Butt, Louise E., Prior, Stephen H., Read, Christopher M., Fields, Gregg B., Pickford, Andrew R.

“…Matrix metalloproteinase-1 (MMP-1) is an instigator of collagenolysis, the catabolism of triple helical collagen. Previous studies have implicated its…”
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High throughput screening of 0.5 million compounds against CRAF using Alpha CETSA by Rowlands, Hannah, Tschapalda, Kirsten, Blackett, Carolyn, Ivanov, Delyan, Plant, Darren, Shaw, Joseph, Thomas, Andrew, Packer, Martin, Arnold, Laurence, Holdgate, Geoffrey A.

“…The cellular thermal shift assay (CETSA®) has increasingly been used in early drug discovery to provide a measure of cellular target engagement. Traditionally,…”
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Abstract 4723: Target engagement sheds light on difference in drug efficacy in breast cancer cell lines by Friman, Tomas, Tolvanen, Tuomas, Kacal, Merve, Brehmer, Victoria, Lundgren, Stina, Arnold, Laurence, Molina, Daniel Martinez

“…Abstract Breast cancer is a serious disease that affects millions of women worldwide, and 700,000 people succumb to the disease annually. Breast cancers are…”
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Abstract 3096: CETSA Navigate HT: A new paradigm for high-throughput screening by Almqvist, Helena, Brehmer, Victoria, Arnold, Laurence, Friman, Tomas, Lundgren, Stina, Molina, Daniel Martinez

“…Abstract The CEllular Thermal Shift Assay (CETSA) technology is a powerful way to assess target engagement across various matrixes. By the introduction of the…”
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Abstract 3097: CETSA HT: Employing rapid high-throughput target engagement technology in primary screening of P53 by Kacal, Merve, Friman, Tomas, Arnold, Laurence, Brehmer, Victoria, Molina, Daniel Martinez, Lundgren, Stina

“…Abstract The confirmation of target engagement for candidate drugs is a fundamental requisite in drug discovery. A significant portion of projects fail to…”
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CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target by Friman, Tomas, Chernobrovkin, Alexey, Martinez Molina, Daniel, Arnold, Laurence

“…The reuse of preexisting small molecules for a novel emerging disease threat is a rapid measure to discover unknown applications for previously validated…”
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Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction: e1005194 by Arnold, Laurence H, Groom, Harriet CT, Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J, Ordonez, Paula, Mann, Melanie C, Rueschenbaum, Sabrina, Goldstone, David C, Pennell, Simon, Howell, Steven A, Stoye, Jonathan P, Webb, Michelle, Taylor, Ian A, Bishop, Kate N

“…SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase…”
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Persuading school-age cyclists to use safety helmets: Effectiveness of an intervention based on the Theory of Planned Behaviour by Quine, Lyn, Rutter, D. R., Arnold, Laurence

“…Objectives. To design and evaluate a theory‐based intervention to encourage the use of protective helmets in school‐age cyclists. Design. Two‐by‐three mixed…”
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Predicting and understanding safety helmet use among schoolboy cyclists: A comparison of the theory of planned behaviour and the health belief model by Quine, Lyn, Rutter, D. R., Arnold, Laurence

“…The paper reports a prospective longitudinal comparison of the Health Belief Model (Rosenstock, 1966) and the Theory of Planned Behaviour (Ajzen, 1985) in…”
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Comparing the Utility of the Theory of Planned Behaviour and the Health Belief Model in Understanding and Promoting the Use of Protective Helmets Among School-Age Cyclists by Arnold, Laurence

“…The thesis set out to compare the Health Belief Model (Rosenstock, 1966, 1974) and the Theory of Planned Behaviour (Ajzenm 1985,1991) in terms of their…”
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'King of Wall Street' ruled at Salomon Brothers by Arnold, Laurence

“…Readers of the book were introduced to Mr. Gutfreund and to the particular ways of Wall Street, including the game referenced by the title, which involves…”
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Amazon CFO worked with firm's investors by Arnold, Laurence

“…Joy Covey, who helped take Amazon.com public as the Internet retailer's chief financial officer, died Sept. 18 after colliding with a minivan while riding her…”
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Wall Street bond expert paved path for women by Arnold, Laurence

“…According to the profile in the Bryn Mawr Alumnae Bulletin, she recalled that a dean who learned of her interest in working on Wall Street urged her to enroll…”
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CEO refocused direction of Honeywell by Arnold, Laurence

“…Midway through Mr. Spencer's tenure, Honeywell's top competitor in mainframe computers, International Business Machines, settled a long-running antitrust…”
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N.Y. banker contributed money, time to cancer group for young people by Arnold, Laurence

“…Mr. Hill, who was co-head of global equity finance, a unit within the New York-based bank's prime brokerage business, served on the board of the SAMFund, a…”
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Hong Kong banker created Hang Seng index by Arnold, Laurence

“…According to the draft notes for a speech Mr. Kwan gave in 2009 in Vancouver, the Hong Kong economy had hit "rock bottom" after riots related to China's…”
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