Search Results - "Arnold, Jack"
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COVID-19 vaccination and antirheumatic therapy
Published in Rheumatology (Oxford, England) (12-03-2021)“…The COVID-19 vaccination will be the largest vaccination programme in the history of the NHS. Patients on immunosuppressive therapy will be amongst the…”
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Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food
Published in Cell reports (Cambridge) (31-10-2023)“…The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features of…”
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A Personalized Rituximab Retreatment Approach Based on Clinical and B-Cell Biomarkers in ANCA-Associated Vasculitis
Published in Frontiers in immunology (12-01-2022)“…Time to relapse after rituximab for the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is variable, and optimal…”
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Dynamic Control of Gene Expression with Riboregulated Switchable Feedback Promoters
Published in ACS synthetic biology (21-05-2021)“…One major challenge in synthetic biology is the deleterious impacts of cellular stress caused by expression of heterologous pathways, sensors, and circuits…”
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P155 Identifying a population of patients for intensive first-line therapy in SLE: a clinical and biomarker model to predict the need for intensive therapy
Published in Lupus science & medicine (14-03-2024)“…ObjectiveTo investigate the clinical and biomarkers factors predicting a requirement for intensive therapy or time to intensive therapy from diagnosis of…”
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A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody
Published in PloS one (01-06-2015)“…The CCR5 receptor plays a role in several key physiological and pathological processes and is an important therapeutic target. Inhibition of the CCR5 axis by…”
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Predicting Sustained Clinical Response to Rituximab in Moderate to Severe Systemic Manifestations of Primary Sjögren Syndrome
Published in ACR open rheumatology (01-08-2022)“…Objective To assess outcomes of repeat rituximab cycles and identify predictors of sustained clinical response in systemic manifestations of primary Sjögren…”
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The Internet and Semantic Structure: A Re-Examination
Published in Methodological innovations (01-04-2011)“…I discuss an earlier article arguing that Google counts for paired concepts reflect the similarity of concepts and that analysis of sets of paired queries…”
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Genetic Engineering of Resident Bacteria in the Gut Microbiome
Published in Journal of bacteriology (25-07-2023)“…Techniques by which to genetically manipulate members of the microbiota enable both the evaluation of host-microbe interactions and an avenue by which to…”
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Gut microbiome-derived isodeoxycholic acid promotes mucosal immune non-responsiveness
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract Perturbations to the commensal gut microbiota are associated with the increasing prevalence of food allergies. Our lab has reported that colonization…”
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Nine Psychologists: Mapping the Collective Mind with Google
Published in Current research in social psychology (01-01-2006)“…All pairs of names generated by the individual names of nine historically important psychologists were submitted as queries to the Google search engine. The…”
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Proceedings from the 3rd International Conference on Microbiome Engineering
Published in Biotechnology progress (01-05-2022)“…The human microbiome has been inextricably linked to multiple facets of human physiology. From an engineering standpoint, the ability to precisely control the…”
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The differential influence of commensal and pathogenic flagella on intestinal barrier function
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract It is well known that accumulated changes in microbiota composition over several decades have contributed to an increase in non-communicable chronic…”
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OA26 Characterisation of a basket trial population for arthritis associated with ANA-positive RMDs
Published in Rheumatology (Oxford, England) (24-04-2023)“…Abstract Background/Aims Musculoskeletal inflammation is the most common reason for the inclusion of patients in SLE trials or biologic use. It is also common…”
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ANA-associated arthritis: clinical and biomarker characterization of a population for basket trials
Published in Rheumatology (Oxford, England) (01-11-2024)“…Abstract Objectives ANA-associated rheumatic and musculoskeletal (MSK) diseases (RMDs) [SLE, primary SS (pSS), scleroderma, inflammatory myositis, MCTD and…”
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Flagella and indole produced by commensal bacteria protect the intestinal barrier to prevent food allergy
Published in The Journal of immunology (1950) (01-05-2022)“…Abstract Lifestyle-induced changes to the diversity of the commensal microbiota have been causally linked to the increasing prevalence of food allergies and…”
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Efficacy and safety of obinutuzumab in systemic lupus erythematosus patients with secondary non-response to rituximab
Published in Rheumatology (Oxford, England) (28-11-2022)“…Secondary inefficacy with infusion reactions and anti-drug antibodies (secondary non-depletion nonresponse, 2NDNR) occurs in 14% of SLE patients receiving…”
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P245 Identifying predictors of short-term response to rituximab in extra-glandular primary Sjogren’s Syndrome
Published in Rheumatology (Oxford, England) (23-04-2022)“…Abstract Background/Aims Randomised controlled trials (RCTs) of rituximab (RTX) in primary Sjogren’s syndrome (pSS) have failed to alleviate glandular symptoms…”
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Clostridia metabolites promote intestinal barrier integrity to protect from food allergy
Published in The Journal of immunology (1950) (01-05-2021)“…Abstract We previously reported that a consortium of bacteria from the Clostridia class modulates intestinal barrier function through induction of IL-22 and…”
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A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice
Published in Cell host & microbe (10-07-2024)“…Depletion of beneficial microbes by modern lifestyle factors correlates with the rising prevalence of food allergies. Re-introduction of allergy-protective…”
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