Search Results - "Arnold, H."

Directed Evolution: Bringing New Chemistry to Life by Arnold, Frances H.

“…Tailor‐made: Discussed herein is the ability to adapt biology's mechanisms for innovation and optimization to solving problems in chemistry and engineering…”
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Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture) by Arnold, Frances H.

“…The directed evolution of enzymes is now routinely used to develop new catalysts with various applications, such as in environmentally friendly production of…”
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Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer by Yang, Yang, Arnold, Frances H

“…Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes, enzymes do not catalyze many of the transformations favored by…”
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Machine-learning-guided directed evolution for protein engineering by Yang, Kevin K., Wu, Zachary, Arnold, Frances H.

“…Protein engineering through machine-learning-guided directed evolution enables the optimization of protein functions. Machine-learning approaches predict how…”
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New-to-nature chemistry from old protein machinery: carbene and nitrene transferases by Liu, Zhen, Arnold, Frances H

“…[Display omitted] •New-to-nature carbene and nitrene transfer enzymes inspired by chemical catalysis.•Engineered hemoproteins that catalyze these…”
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Chosen Name Use Is Linked to Reduced Depressive Symptoms, Suicidal Ideation, and Suicidal Behavior Among Transgender Youth by Russell, Stephen T., Pollitt, Amanda M., Li, Gu, Grossman, Arnold H.

“…This study aimed to examine the relation between chosen name use, as a proxy for youths' gender affirmation in various contexts, and mental health among…”
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Engineering Cytochrome P450s for Enantioselective Cyclopropenation of Internal Alkynes by Chen, Kai, Arnold, Frances H

“…We report a biocatalytic platform of engineered cytochrome P450 enzymes to carry out efficient cyclopropene synthesis via carbene transfer to internal alkynes…”
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Minority Stress and Mechanisms of Risk for Depression and Suicidal Ideation Among Lesbian, Gay, and Bisexual Youth by Baams, Laura, Grossman, Arnold H., Russell, Stephen T.

“…The experience of minority stress is often named as a cause for mental health disparities among lesbian, gay, and bisexual (LGB) youth, including higher levels…”
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Driving quality improvement with nudges: True interventions in cardiology by Seto, Arnold H.

“…Key Points Quality improvement research brings evidence‐based interventions to clinical practice. This single‐center study demonstrated that simple clinical…”
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PIC Simulations of Overstretched Ion‐Scale Current Sheets in the Magnetotail by Arnold, H., Sitnov, M. I.

“…Onset of reconnection in the tail requires the current sheet thickness to be of the order of the ion thermal gyroradius or smaller. However, existing isotropic…”
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Cut, score, press, shock, or ablate? by Seto, Arnold H.

“…Key Points Cutting balloon angioplasty can modify fibrous or mildly calcified plaques before stent implantation. The present randomized study shows that…”
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The nature of chemical innovation: new enzymes by evolution by Arnold, Frances H

“…I describe how we direct the evolution of non-natural enzyme activities, using chemical intuition and information on structure and mechanism to guide us to the…”
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An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)–H bonds by Yang, Yang, Cho, Inha, Qi, Xiaotian, Liu, Peng, Arnold, Frances H.

“…The ability to selectively functionalize ubiquitous C–H bonds streamlines the construction of complex molecular architectures from easily available precursors…”
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Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution by Renata, Hans, Wang, Z. Jane, Arnold, Frances H.

“…High selectivity and exquisite control over the outcome of reactions entice chemists to use biocatalysts in organic synthesis. However, many useful reactions…”
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Enzymatic Primary Amination of Benzylic and Allylic C(sp 3 )-H Bonds by Jia, Zhi-Jun, Gao, Shilong, Arnold, Frances H

“…Aliphatic primary amines are prevalent in natural products, pharmaceuticals, and functional materials. While a plethora of processes are reported for their…”
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Limitations of Long-Term Mortality as a Clinical Trial Endpoint: Time Wounds All Healing by Seto, Arnold H

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Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life by Kan, S. B. Jennifer, Lewis, Russell D., Chen, Kai, Arnold, Frances H.

“…Enzymes that catalyze carbon-silicon bond formation are unknown in nature, despite the natural abundance of both elements. Such enzymes would expand the…”
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Exploring protein fitness landscapes by directed evolution by Romero, Philip A, Arnold, Frances H

“…Key Points Directed evolution optimizes protein function by the successive generations of random mutation, artificial selection or screening. This simple…”
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Closing the loop in cath lab communication: Avoiding the tower of babble by Seto, Arnold H.

“…Key points Closed‐loop communication (CLC) can reduce miscommunication and medical errors. This quality improvement study showed that CLC was poor at baseline,…”
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Electron Acceleration during Macroscale Magnetic Reconnection by Arnold, H, Drake, J F, Swisdak, M, Guo, F, Dahlin, J T, Chen, B, Fleishman, G, Glesener, L, Kontar, E, Phan, T, Shen, C

“…The first self-consistent simulations of electron acceleration during magnetic reconnection in a macroscale system are presented. Consistent with solar flare…”
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