Search Results - "Arnold, Donald M"

Bleeding complications in immune thrombocytopenia by Arnold, Donald M

“…Bleeding manifestations in patients with immune thrombocytopenia (ITP) range from mild skin bruises to life-threatening intracranial hemorrhage (ICH). Severe…”
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Thrombocytopenia following Pfizer and Moderna SARS‐CoV‐2 vaccination by Lee, Eun‐Ju, Cines, Douglas B., Gernsheimer, Terry, Kessler, Craig, Michel, Marc, Tarantino, Michael D., Semple, John W., Arnold, Donald M., Godeau, Bertrand, Lambert, Michele P., Bussel, James B.

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Recommendations for the clinical and laboratory diagnosis of VITT against COVID‐19: Communication from the ISTH SSC Subcommittee on Platelet Immunology by Nazy, Ishac, Sachs, Ulrich J., Arnold, Donald M., McKenzie, Steven E., Choi, Phil, Althaus, Karina, Ahlen, Maria Therese, Sharma, Ruchika, Grace, Rachael F., Bakchoul, Tamam

“…Vaccine administration is under way worldwide to combat the current COVID‐19 pandemic. The newly developed vaccines are highly effective with minimal adverse…”
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Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo‐controlled trials by Bussel, James, Arnold, Donald M., Grossbard, Elliot, Mayer, Jiří, Treliński, Jacek, Homenda, Wojciech, Hellmann, Andrzej, Windyga, Jerzy, Sivcheva, Liliya, Khalafallah, Alhossain A., Zaja, Francesco, Cooper, Nichola, Markovtsov, Vadim, Zayed, Hany, Duliege, Anne‐Marie

“…Spleen tyrosine kinase (Syk) signaling is central to phagocytosis‐based, antibody‐mediated platelet destruction in adults with immune thrombocytopenia (ITP)…”
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American Society of Hematology 2019 guidelines for immune thrombocytopenia by Neunert, Cindy, Terrell, Deirdra R., Arnold, Donald M., Buchanan, George, Cines, Douglas B., Cooper, Nichola, Cuker, Adam, Despotovic, Jenny M., George, James N., Grace, Rachael F., Kühne, Thomas, Kuter, David J., Lim, Wendy, McCrae, Keith R., Pruitt, Barbara, Shimanek, Hayley, Vesely, Sara K.

“…Background: Despite an increase in the number of therapies available to treat patients with immune thrombocytopenia (ITP), there are minimal data from…”
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Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion by Heddle, Nancy M, Cook, Richard J, Arnold, Donald M, Liu, Yang, Barty, Rebecca, Crowther, Mark A, Devereaux, P.J, Hirsh, Jack, Warkentin, Theodore E, Webert, Kathryn E, Roxby, David, Sobieraj-Teague, Magdalena, Kurz, Andrea, Sessler, Daniel I, Figueroa, Priscilla, Ellis, Martin, Eikelboom, John W

“…In a pragmatic trial, more than 30,000 patients requiring blood transfusion were randomly assigned to receive blood after short-term storage or long-term…”
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Updated international consensus report on the investigation and management of primary immune thrombocytopenia by Provan, Drew, Arnold, Donald M., Bussel, James B., Chong, Beng H., Cooper, Nichola, Gernsheimer, Terry, Ghanima, Waleed, Godeau, Bertrand, González-López, Tomás José, Grainger, John, Hou, Ming, Kruse, Caroline, McDonald, Vickie, Michel, Marc, Newland, Adrian C., Pavord, Sue, Rodeghiero, Francesco, Scully, Marie, Tomiyama, Yoshiaki, Wong, Raymond S., Zaja, Francesco, Kuter, David J.

“…Over the last decade, there have been numerous developments and changes in treatment practices for the management of patients with immune thrombocytopenia…”
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The effect of rituximab on humoral and cell mediated immunity and infection in the treatment of autoimmune diseases by Cooper, Nichola, Arnold, Donald M.

“…Summary Depletion of B lymphocytes using the anti‐CD20 monoclonal antibody rituximab has wide‐spread use in the treatment of patients with autoimmune…”
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The platelet serotonin‐release assay by Warkentin, Theodore E., Arnold, Donald M., Nazi, Ishac, Kelton, John G.

“…Few laboratory tests are as clinically useful as The platelet serotonin‐release assay (SRA): a positive SRA in the appropriate clinical context is virtually…”
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Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group by Rodeghiero, Francesco, Stasi, Roberto, Gernsheimer, Terry, Michel, Marc, Provan, Drew, Arnold, Donald M., Bussel, James B., Cines, Douglas B., Chong, Beng H., Cooper, Nichola, Godeau, Bertrand, Lechner, Klaus, Mazzucconi, Maria Gabriella, McMillan, Robert, Sanz, Miguel A., Imbach, Paul, Blanchette, Victor, Kühne, Thomas, Ruggeri, Marco, George, James N.

“…Diagnosis and management of immune thrombocytopenic purpura (ITP) remain largely dependent on clinical expertise and observations more than on evidence derived…”
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The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta‐analysis of a diagnostic test by Vrbensky, John R., Moore, Joyce E., Arnold, Donald M., Smith, James W., Kelton, John G., Nazy, Ishac

“…Essentials The diagnosis of ITP is based on a platelet count < 100 × 109 L−1 and exclusion of other causes. There are no standard tests or biomarkers to…”
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Venous Thromboembolism and Mild Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination by Gabarin, Nadia, Patterson, Sarah, Pai, Menaka, Afzaal, Tamoor, Nazy, Ishac, Sheppard, Jo-Ann I, Arnold, Donald M, Warkentin, Theodore E

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Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia by Gabe, Caroline, Liu, Yang, Duncan, Joanne, St John, Melanie, Lucier, Kayla J., Kimmel, David, Kelton, John G., Arnold, Donald M.

“…The association between T-cell large granular lymphocytes (T-LGL) and ITP is uncertain. The aims of this study were to determine the prevalence of T-LGL in…”
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Performance characteristics of an automated latex immunoturbidimetric assay [HemosIL® HIT-ab(PF4-H) ] for the diagnosis of immune heparin-induced thrombocytopenia by Warkentin, Theodore E, Sheppard, Jo-Ann I, Linkins, Lori-Ann, Arnold, Donald M, Nazy, Ishac

“…Abstract Background Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-activating anti-PF4/heparin antibodies. Given…”
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High-dose dexamethasone compared with prednisone for previously untreated primary immune thrombocytopenia: a systematic review and meta-analysis by Mithoowani, Siraj, MD, Gregory-Miller, Kathleen, MD, Goy, Jennifer, MD, Miller, Matthew C, MD, Wang, Grace, MMath, Noroozi, Nastaran, MD, Kelton, John G, Prof, Arnold, Donald M, Dr

“…Summary Background Whether high-dose dexamethasone has long-term efficacy and safety in previously untreated patients with immune thrombocytopenia is unclear…”
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Systematic review of rituximab for autoimmune diseases: a potential alternative to intravenous immune globulin by MacIsaac, John, Siddiqui, Reda, Jamula, Erin, Li, Na, Baker, Steven, Webert, Kathryn E., Evanovitch, Denise, Heddle, Nancy M., Arnold, Donald M.

“…BACKGROUND The anti‐CD20 monoclonal antibody rituximab has immune‐modulatory effects similar to intravenous immunoglobulin (IVIG). We performed a systematic…”
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Approach to the Diagnosis and Management of Drug-Induced Immune Thrombocytopenia by Arnold, Donald M, Nazi, Ishac, Warkentin, Theodore E, Smith, James W, Toltl, Lisa J, George, James N, Kelton, John G

“…Abstract Drug-induced immune thrombocytopenia (DITP) is a challenging clinical problem that is under-recognized, difficult to diagnose and associated with…”
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Unique features of vaccine-induced immune thrombotic thrombocytopenia; a new anti-platelet factor 4 antibody-mediated disorder by Venier, Laura M., Clerici, Bianca, Bissola, Anna-Lise, Modi, Dimpy, Jevtic, Stefan D., Radford, Michael, Mahamad, Syed, Nazy, Ishac, Arnold, Donald M.

“…Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a highly prothrombotic disorder caused by anti-PF4 antibodies that activate platelets and…”
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Misdiagnosis of primary immune thrombocytopenia and frequency of bleeding: lessons from the McMaster ITP Registry by Arnold, Donald M., Nazy, Ishac, Clare, Rumi, Jaffer, Anushka M., Aubie, Brandon, Li, Na, Kelton, John G.

“…Nonspecific diagnostic criteria and uncertain estimates of severe bleeding events are fundamental gaps in knowledge of primary immune thrombocytopenia (ITP)…”
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Post-cardiac surgery thrombotic thrombocytopenic purpura: presence of anti-ADAMTS13 autoantibodies at preoperative baseline by Tordon, Bryan, Warkentin, Theodore E., Moore, Jane C., Arnold, Donald M.

“…Thrombotic thrombocytopenic purpura (TTP) rarely complicates acute inflammatory conditions such as surgery, including post-cardiac surgery. Review of 32…”
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