Search Results - "Arnold, Allison L"

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS by Hodges, Timothy R, Abbott, Jason R, Little, Andrew J, Sarkar, Dhruba, Salovich, James M, Howes, Jennifer E, Akan, Denis T, Sai, Jiqing, Arnold, Allison L, Browning, Carrie, Burns, Michael C, Sobolik, Tammy, Sun, Qi, Beesetty, Yugandhar, Coker, Jesse A, Scharn, Dirk, Stadtmueller, Heinz, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, McConnell, Darryl B, Fesik, Stephen W

“…Son of sevenless homologue 1 (SOS1) is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS. In its active form, GTP-bound…”
Get full text

Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods by Pelz, Nicholas F, Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C, Belmar, Johannes, Gregg, Claire, Camper, DeMarco V, Goodwin, Craig M, Arnold, Allison L, Sensintaffar, John L, Friberg, Anders, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

“…Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins responsible for the regulation of programmed cell death. Amplification of Mcl-1 is…”
Get full text

Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia‑1 Inhibitors Using Structure-Based Design by Shaw, Subrata, Bian, Zhiguo, Zhao, Bin, Tarr, James C, Veerasamy, Nagarathanam, Jeon, Kyu Ok, Belmar, Johannes, Arnold, Allison L, Fogarty, Stuart A, Perry, Evan, Sensintaffar, John L, Camper, DeMarco V, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

“…Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins, has emerged as an attractive target for cancer therapy. Mcl-1…”
Get full text

Discovery of Potent Myeloid Cell Leukemia‑1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer by Lee, Taekyu, Christov, Plamen P, Shaw, Subrata, Tarr, James C, Zhao, Bin, Veerasamy, Nagarathanam, Jeon, Kyu Ok, Mills, Jonathan J, Bian, Zhiguo, Sensintaffar, John L, Arnold, Allison L, Fogarty, Stuart A, Perry, Evan, Ramsey, Haley E, Cook, Rebecca S, Hollingshead, Melinda, Davis Millin, Myrtle, Lee, Kyung-min, Koss, Brian, Budhraja, Amit, Opferman, Joseph T, Kim, Kwangho, Arteaga, Carlos L, Moore, William J, Olejniczak, Edward T, Savona, Michael R, Fesik, Stephen W

“…Overexpression of myeloid cell leukemia-1 (Mcl-1) in cancers correlates with high tumor grade and poor survival. Additionally, Mcl-1 drives intrinsic and…”
Get full text

Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors by Lee, Taekyu, Bian, Zhiguo, Zhao, Bin, Hogdal, Leah J., Sensintaffar, John L., Goodwin, Craig M., Belmar, Johannes, Shaw, Subrata, Tarr, James C., Veerasamy, Nagarathanam, Matulis, Shannon M., Koss, Brian, Fischer, Melissa A., Arnold, Allison L., Camper, DeMarco V., Browning, Carrie F., Rossanese, Olivia W., Budhraja, Amit, Opferman, Joseph, Boise, Lawrence H., Savona, Michael R., Letai, Anthony, Olejniczak, Edward T., Fesik, Stephen W.

“…Myeloid cell leukemia 1 (Mcl‐1) is an antiapoptotic member of the Bcl‐2 family of proteins that when overexpressed is associated with high tumor grade, poor…”
Get full text

Differences in Abdominal Muscle Thickness, Strength, and Endurance in Persons Who Are Runners, Active, and Inactive by Schaeffer, Beth H., Anemaet, Wendy K., Arnold, Allyson L., Brabham, Autumn B., Groom, Nancy K., Moore, Cassidee R.

“…Background: Core musculature is important for efficiency during activities including running. Both abdominal muscle strength and endurance contribute to this…”
Get full text

Understanding the Species Selectivity of Myeloid Cell Leukemia‑1 (Mcl-1) Inhibitors by Zhao, Bin, Arnold, Allison L, Coronel, Marcelle A, Lee, Joyce H, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

“…To test for on target toxicity of a new chemical entity, it is important to have comparable binding affinities of the compound in the target proteins from…”
Get full text

Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses by Akan, Denis T, Howes, Jennifer E, Sai, Jiqing, Arnold, Allison L, Beesetty, Yugandhar, Phan, Jason, Olejniczak, Edward T, Waterson, Alex G, Fesik, Stephen W

“…Activating mutations in RAS can lead to oncogenesis by enhancing downstream signaling, such as through the MAPK and PI3K pathways. Therefore, therapeutically…”
Get full text

Abstract 3551: Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines by Lee, Taekyu, Bian, Zhiguo, Belmar, Johannes, Shaw, Subrata, Tarr, James C., Zhao, Bin, Pelz, Nick, Camper, DeMarco, Goodwin, Craig M., Arnold, Allison L., Sensintaffar, John L., Browning, Carrie F., Rossanese, Olivia W., Olejniczak, Edward T., Fesik, Stephen W.

“…Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that regulate apoptosis. Amplification of Mcl-1 is found in various cancers, which…”
Get full text

Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors by Lee, Taekyu, Bian, Zhiguo, Zhao, Bin, Hogdal, Leah J., Sensintaffar, John L., Goodwin, Craig M., Belmar, Johannes, Shaw, Subrata, Tarr, James C., Veerasamy, Nagarathanam, Matulis, Shannon M., Koss, Brian, Fischer, Melissa A., Arnold, Allison L., Camper, DeMarco V., Browning, Carrie F., Rossanese, Olivia W., Budhraja, Amit, Opferman, Joseph, Boise, Lawrence H., Savona, Michael R., Letai, Anthony, Olejniczak, Edward T., Fesik, Stephen W.

Get full text