Search Results - "Arnett, Eusondia"

Macrophage nuclear receptors: Emerging key players in infectious diseases by Leopold Wager, Chrissy M, Arnett, Eusondia, Schlesinger, Larry S

“…Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a variety of cells, including macrophages. For decades, NRs have been…”
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PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis by Arnett, Eusondia, Weaver, Ashlee M, Woodyard, Kiersten C, Montoya, Maria J, Li, Michael, Hoang, Ky V, Hayhurst, Andrew, Azad, Abul K, Schlesinger, Larry S

“…Peroxisome proliferator-activated receptor (PPAR)γ is a global transcriptional regulator associated with anti-inflammatory actions. It is highly expressed in…”
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M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1 by Rajaram, Murugesan V.S., Arnett, Eusondia, Azad, Abul K., Guirado, Evelyn, Ni, Bin, Gerberick, Abigail D., He, Li-Zhen, Keler, Tibor, Thomas, Lawrence J., Lafuse, William P., Schlesinger, Larry S.

“…Despite its prominent role as a C-type lectin (CTL) pattern recognition receptor, mannose receptor (MR, CD206)-specific signaling molecules and pathways are…”
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Human isotype‐dependent inhibitory antibody responses against Mycobacterium tuberculosis by Zimmermann, Natalie, Thormann, Verena, Hu, Bo, Köhler, Anne‐Britta, Imai‐Matsushima, Aki, Locht, Camille, Arnett, Eusondia, Schlesinger, Larry S, Zoller, Thomas, Schürmann, Mariana, Kaufmann, Stefan HE, Wardemann, Hedda

“…Accumulating evidence from experimental animal models suggests that antibodies play a protective role against tuberculosis (TB). However, little is known about…”
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Systems biology approaches to investigate the role of granulomas in TB-HIV coinfection by Hoerter, Alexis, Arnett, Eusondia, Schlesinger, Larry S, Pienaar, Elsje

“…The risk of active tuberculosis disease is 15-21 times higher in those coinfected with human immunodeficiency virus-1 (HIV) compared to tuberculosis alone, and…”
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Activation of transcription factor CREB in human macrophages by Mycobacterium tuberculosis promotes bacterial survival, reduces NF-kB nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling by Leopold Wager, Chrissy M, Bonifacio, Jordan R, Simper, Jan, Naoun, Adrian A, Arnett, Eusondia, Schlesinger, Larry S

“…Macrophages are a first line of defense against pathogens. However, certain invading microbes modify macrophage responses to promote their own survival and…”
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The Mycobacterium tuberculosis MmpL11 Cell Wall Lipid Transporter Is Important for Biofilm Formation, Intracellular Growth, and Nonreplicating Persistence by Wright, Catherine C, Hsu, Fong Fu, Arnett, Eusondia, Dunaj, Jennifer L, Davidson, Patrick M, Pacheco, Sophia A, Harriff, Melanie J, Lewinsohn, David M, Schlesinger, Larry S, Purdy, Georgiana E

“…The mycobacterial cell wall is crucial to the host-pathogen interface, because it provides a barrier against antibiotics and the host immune response. In…”
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The multifaceted activities of mammalian defensins by Arnett, Eusondia, Seveau, Stéphanie

“…Defensins are an important family of cationic and cysteine-rich host defense peptides that are widely distributed in plants, fungi, and animals. In mammals,…”
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The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes by Vadia, Stephen, Arnett, Eusondia, Haghighat, Anne-Cécile, Wilson-Kubalek, Elisabeth M, Tweten, Rodney K, Seveau, Stephanie

“…Intracellular pathogens have evolved diverse strategies to invade and survive within host cells. Among the most studied facultative intracellular pathogens,…”
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Combination of MCL-1 and BCL-2 inhibitors is a promising approach for a host-directed therapy for tuberculosis by Arnett, Eusondia, Pahari, Susanta, Leopold Wager, Chrissy M., Hernandez, Elizabeth, Bonifacio, Jordan R., Lumbreras, Miranda, Renshaw, Charles, Montoya, Maria J., Opferman, Joseph T., Schlesinger, Larry S.

“…Tuberculosis (TB) accounts for 1.6 million deaths annually and over 25% of deaths due to antimicrobial resistance. Mycobacterium tuberculosis (M.tb) drives…”
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A new tractable method for generating human alveolar macrophage-like cells in vitro to study lung inflammatory processes and diseases by Pahari, Susanta, Arnett, Eusondia, Simper, Jan, Azad, Abul, Guerrero-Arguero, Israel, Ye, Chengjin, Zhang, Hao, Cai, Hong, Wang, Yufeng, Lai, Zhao, Jarvis, Natalie, Lumbreras, Miranda, Maselli, Diego Jose, Peters, Jay, Torrelles, Jordi B, Martinez-Sobrido, Luis, Schlesinger, Larry S

“…Alveolar macrophages (AMs) are unique lung resident cells that contact airborne pathogens and environmental particulates. The contribution of human AMs (HAMs)…”
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E-cigs put the squeeze on macrophages by Arnett, Eusondia, Schlesinger, Larry S

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Live and let die: TB control by enhancing apoptosis by Arnett, Eusondia, Schlesinger, Larry S.

“…The impact of cellular apoptosis in controlling M. tuberculosis during tuberculosis (TB) infection remains unresolved. In this issue of Immunity, Stutz et al…”
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Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of Mycobacterium tuberculosis by Pahari, Susanta, Negi, Shikha, Aqdas, Mohammad, Arnett, Eusondia, Schlesinger, Larry S., Agrewala, Javed N

“…Host-directed therapies are gaining considerable impetus because of the emergence of drug-resistant strains of pathogens due to antibiotic therapy. Therefore,…”
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Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells by Phelps, Christopher C, Vadia, Stephen, Arnett, Eusondia, Tan, Yubo, Zhang, Xiaoli, Pathak-Sharma, Sarika, Gavrilin, Mikhail A, Seveau, Stephanie

“…is a facultative intracellular pathogen that infects a wide variety of cells, causing the life-threatening disease listeriosis. virulence factors include two…”
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Characterization of AIM2 expression in human macrophages during M. tuberculosis infection by Ontiveros, Carlos Oscar, Arnett, Eusondia, Schlesinger, Larry S.

“…Abstract Tuberculosis (TB) is a leading contributor to global mortality and is a well-known threat to global health. The disease-causing bacterium,…”
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Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication by Batra, Jyoti, Hultquist, Judd F., Liu, Dandan, Shtanko, Olena, Von Dollen, John, Satkamp, Laura, Jang, Gwendolyn M., Luthra, Priya, Schwarz, Toni M., Small, Gabriel I., Arnett, Eusondia, Anantpadma, Manu, Reyes, Ann, Leung, Daisy W., Kaake, Robyn, Haas, Paige, Schmidt, Carson B., Schlesinger, Larry S., LaCount, Douglas J., Davey, Robert A., Amarasinghe, Gaya K., Basler, Christopher F., Krogan, Nevan J.

“…Ebola virus (EBOV) infection often results in fatal illness in humans, yet little is known about how EBOV usurps host pathways during infection. To address…”
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Ebola Virus Uses Tunneling Nanotubes as an Alternate Route of Dissemination by Djurkovic, Marija A, Leavitt, Carson G, Arnett, Eusondia, Kriachun, Valeriia, Martínez-Sobrido, Luis, Titone, Rossella, Sherwood, Laura J, Hayhurst, Andrew, Schlesinger, Larry S, Shtanko, Olena

“…Abstract Ebola virus (EBOV) disease is marked by rapid virus replication and spread. EBOV enters the cell by macropinocytosis and replicates in the cytoplasm,…”
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Cutting Edge: Cytosolic Receptor AIM2 Is Induced by Peroxisome Proliferator-activated Receptor γ following Mycobacterium tuberculosis Infection of Human Macrophages but Does Not Contribute to IL-1β Release by Arnett, Eusondia, Wolff, Jade, Leopold Wager, Chrissy M, Simper, Jan, Badrak, Jeanine L, Ontiveros, Carlos O, Ni, Bin, Schlesinger, Larry S

“…AIM2 (absent in melanoma 2), an inflammasome component, mediates IL-1β release in murine macrophages and cell lines. AIM2 and IL-1β contribute to murine…”
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Mycobacterium tuberculosis and macrophage nuclear receptors: What we do and don't know by Leopold Wager, Chrissy M., Arnett, Eusondia, Schlesinger, Larry S.

“…Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a wide variety of cells and play a major role in lipid signaling. NRs…”
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