Search Results - "Arneric, S. P."

Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors by Bannon, A. W., Decker, M. W., Holladay, M. W., Curzon, P., Donnelly-Roberts, D., Puttfarcken, P. S., Bitner, R. S., Diaz, A., Dickenson, A. H., Porsolt, R. D., Williams, M., Arneric, S. P.

“…Development of analgesic agents for the treatment of severe pain requires the identification of compounds that are devoid of opioid receptor liabilities. A…”
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Emerging Molecular Approaches to Pain Therapy by Williams, Michael, Kowaluk, Elizabeth A, Arneric, Stephen P

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Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis by Caspary, DM, Raza, A, Lawhorn Armour, BA, Pippin, J, Arneric, SP

“…The present study describes substantial, selective, age-related loss of the putative inhibitory neurotransmitter GABA in the central nucleus of the inferior…”
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Improvement in performance of a delayed matching-to-sample task by monkeys following ABT-418 : a novel cholinergic channel activator for memory enhancement by BUCCAFUSCO, J. J, JACKSON, W. J, TERRY, A. V, MARSH, K. C, DECKER, M. W, ARNERIC, S. P

“…ABT-418, a newly characterized centrally acting cholinergic channel activator (ChCA), was evaluated for its ability to improve performance in a delayed…”
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ABT-594, a novel cholinergic channel modulator, is efficacious in nerve ligation and diabetic neuropathy models of neuropathic pain by Bannon, A.W, Decker, M.W, Kim, D.J.B, Campbell, J.E, Arneric, S.P

“…A novel cholinergic channel modulator, ABT-594, was tested in two established and distinct models of neuropathic pain; the Chung model (i.e., tight ligation of…”
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Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors by Holladay, Mark W, Wasicak, James T, Lin, Nan-Horng, He, Yun, Ryther, Keith B, Bannon, Anthony W, Buckley, Michael J, Kim, David J. B, Decker, Michael W, Anderson, David J, Campbell, Jeffrey E, Kuntzweiler, Theresa A, Donnelly-Roberts, Diana L, Piattoni-Kaplan, Marietta, Briggs, Clark A, Williams, Michael, Arneric, Stephen P

“…New members of a previously reported series of 3-pyridyl ether compounds are disclosed as novel, potent analgesic agents acting through neuronal nicotinic…”
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(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization by Arneric, S P, Sullivan, J P, Briggs, C A, Donnelly-Roberts, D, Anderson, D J, Raszkiewicz, J L, Hughes, M L, Cadman, E D, Adams, P, Garvey, D S

“…A diversity of nicotinic acetylcholine receptor (nAChR) subtypes has been identified in mammalian brain using recombinant DNA technology. Alterations in the…”
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Nicotinic receptor binding of [3H]cytisine, [3H]nicotine and [3H]methylcarbamylcholine in rat brain by Anderson, D J, Arneric, S P

“…Three radiolabeled nicotinic receptor agonists were examined for their binding characteristics and for inhibition by cholinergic compounds in order to…”
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Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys by PRENDERGAST, M. A, JACKSON, W. J, TERRY, A. V, DECKER, M. W, ARNERIC, S. P, BUCCAFUSCO, J. J

“…Increased distractibility is associated with both Alzheimer's disease and attention deficit disorder. The present study examined the effects of (-)-nicotine…”
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Anxiolytic-like effects of the novel cholinergic channel activator ABT-418 by Brioni, J D, O'Neill, A B, Kim, D J, Buckley, M J, Decker, M W, Arneric, S P

“…The hydrochloride salt of (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT-418), a potent activator of select subtypes of neuronal nicotinic…”
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Effects of lobeline, a nicotinic receptor agonist, on learning and memory by Decker, M W, Majchrzak, M J, Arnerić, S P

“…The effects of (-)-lobeline were assessed in two learning and memory tasks in which nicotine-induced enhancement of performance has previously been…”
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In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418 by Donnelly-Roberts, Diana L., Xue, Iris C., Arneric, Stephen P., Sullivan, James P.

“…Recent literature has shown that compounds interacting with neuronal nicotinic acetylcholine receptors (nAChRs) have the potential to be neuroprotective both…”
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Nicotinic agonists modulate basal forebrain control of cortical cerebral blood flow in anesthetized rats by Linville, D G, Williams, S, Raszkiewicz, J L, Arneric, S P

“…Previous studies have indicated that electrical microstimulation of the cholinergic (basal forebrain, BF) elicits profound increases in cortical cerebral blood…”
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Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats by Decker, M W, Curzon, P, Brioni, J D, Arnerić, S P

“…Septal lesions disrupt septohippocampal neurotransmission and impair spatial memory. (-)-Nicotine reduces the memory deficits but has substantial side effect…”
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Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice by Decker, Michael W, Bannon, Anthony W, Buckley, Michael J, Kim, David J.B, Holladay, Mark W, Ryther, Keith B, Lin, Nan-Horng, Wasicak, James T, Williams, Michael, Arneric, Stephen P

“…ABT-594 [5-((2 R)-azetidinylmethoxy)-2-chloropyridine], a novel neuronal nicotinic acetylcholine receptor agonist, produced significant antinociceptive effects…”
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Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation by Raszkiewicz, J L, Linville, D G, Kerwin, Jr, J F, Wagenaar, F, Arneric, S P

“…This study sought to determine whether the activity of nitric oxide synthase (NOS) is an important physiological link required to mediate increases in cortical…”
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Role of voltage-gated calcium channels in ascending pain pathways by Zamponi, Gerald W, Lewis, Richard J, Todorovic, Slobodan M, Arneric, Stephen P, Snutch, Terrance P

“…Abstract Voltage gated calcium channels (VGCCs) are well established mediators of pain signals in primary afferent neurons. N-type calcium channels are…”
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Evidence for Nicotinic Receptors Potentially Modulating Nociceptive Transmission at the Level of the Primary Sensory Neuron: Studies with F11 Cells by Puttfarcken, Pamela S., Manelli, Arlene M., Arneric, Stephen P., Donnelly‐Roberts, Diana L.

“…: F11 cells are a dorsal root ganglion (DRG) cell line used to model the function of authentic type C, peptidergic, nociceptive neurons. The cellular events…”
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Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice by Holladay, Mark W., Bai, Hao, Li, Yihong, Lin, Nan-Horng, Daanen, Jerome F., Ryther, Keith B., Wasicak, James T., Kincaid, John F., He, Yun, Hettinger, Anne-Marie, Huang, Peggy, Anderson, David J., Bannon, Anthony W., Buckley, Michael J., Campbell, Jeffrey E., Donnelly-Roberts, Diana L., Gunther, Karen L., Kim, David J.B., Kuntzweiler, Theresa A., Sullivan, James P., Decker, Michael W., Arneric, Stephen P.

“…Analogs of A-98593 ( 1) and its enantiomer ABT-594 ( 2) with diverse substituents on the pyridine ring were prepared and tested for affinity to nicotinic…”
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Novel Isoxazoles which Interact with Brain Cholinergic Channel Receptors Have Intrinsic Cognitive Enhancing and Anxiolytic Activities by Garvey, David S, Wasicak, James T, Decker, Michael W, Brioni, Jorge D, Buckley, Michael J, Sullivan, James P, Carrera, George M, Holladay, Mark W, Arneric, Stephen P, Williams, Michael

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