Search Results - "Arner, Emily"

Metabolic programming and immune suppression in the tumor microenvironment by Arner, Emily N., Rathmell, Jeffrey C.

“…Increased glucose metabolism and uptake are characteristic of many tumors and used clinically to diagnose and monitor cancer progression. In addition to cancer…”
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Mutation and tissue lineage lead to organ-specific cancer by Arner, Emily N., Rathmell, W. Kimryn

“…Cancer-promoting mutations tend to result in tumours arising only in certain organs, but the reasons for this specificity are not fully understood. The…”
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Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers by Arner, Emily N, Du, Wenting, Brekken, Rolf A

“…Cellular plasticity, a feature associated with epithelial-to-mesenchymal transition (EMT), contributes to tumor cell survival, migration, invasion, and therapy…”
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AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer by Zhang, Yuqing, Arner, Emily N, Rizvi, Ali, Toombs, Jason E, Huang, Huocong, Warner, Steven L, Foulks, Jason M, Brekken, Rolf A

“…Pancreatic cancer is the third leading cause of cancer-related deaths in the United States with a 5-year survival less than 5%. Resistance to standard therapy…”
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Immunometabolism of ferroptosis in the tumor microenvironment by Lupica-Tondo, Gian Luca, Arner, Emily N, Mogilenko, Denis A, Voss, Kelsey

“…Ferroptosis is an iron-dependent form of cell death that results from excess lipid peroxidation in cellular membranes. Within the last decade, physiological…”
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HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma by Bacigalupa, Zachary A, Arner, Emily N, Vlach, Logan M, Wolf, Melissa M, Brown, Whitney A, Krystofiak, Evan S, Ye, Xiang, Hongo, Rachel A, Landis, Madelyn, Amason, Edith K, Beckermann, Kathryn E, Rathmell, W Kimryn, Rathmell, Jeffrey C

“…Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer driven by VHL loss and aberrant HIF-2α signaling. Identifying means to regulate HIF-2α thus has…”
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Deep Learning–Based H-Score Quantification of Immunohistochemistry-Stained Images by Wen, Zhuoyu, Luo, Danni, Wang, Shidan, Rong, Ruichen, Evers, Bret M., Jia, Liwei, Fang, Yisheng, Daoud, Elena V., Yang, Shengjie, Gu, Zifan, Arner, Emily N., Lewis, Cheryl M., Solis Soto, Luisa M., Fujimoto, Junya, Behrens, Carmen, Wistuba, Ignacio I., Yang, Donghan M., Brekken, Rolf A., O'Donnell, Kathryn A., Xie, Yang, Xiao, Guanghua

“…Immunohistochemistry (IHC) is a well-established and commonly used staining method for clinical diagnosis and biomedical research. In most IHC images, the…”
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Obesity induces PD-1 on macrophages to suppress anti-tumour immunity by Bader, Jackie E., Wolf, Melissa M., Lupica-Tondo, Gian Luca, Madden, Matthew Z., Reinfeld, Bradley I., Arner, Emily N., Hathaway, Emma S., Steiner, KayLee K., Needle, Gabriel A., Hatem, Zaid, Landis, Madelyn D., Faneuff, Eden E., Blackman, Amondrea, Wolf, Elysa M., Cottam, Matthew A., Ye, Xiang, Bates, Madison E., Smart, Kyra, Wang, Wenjun, Pinheiro, Laura V., Christofides, Anthos, Smith, DuPreez, Boussiotis, Vassiliki A., Haake, Scott M., Beckermann, Kathryn E., Wellen, Kathryn E., Reinhart-King, Cynthia A., Serezani, C. Henrique, Lee, Cheng-Han, Aubrey, Christa, Chen, Heidi, Rathmell, W. Kimryn, Hasty, Alyssa H., Rathmell, Jeffrey C.

“…Obesity is a leading risk factor for progression and metastasis of many cancers 1 , 2 , yet can in some cases enhance survival 3 – 5 and responses to immune…”
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VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis by Wolf, Melissa M, Madden, Matthew Z, Arner, Emily N, Bader, Jackie E, Ye, Xiang, Vlach, Logan, Tigue, Megan L, Landis, Madelyn D, Jonker, Patrick B, Hatem, Zaid, Steiner, KayLee K, Gaines, Dakim K, Reinfeld, Bradley I, Hathaway, Emma S, Xin, Fuxue, Tantawy, M Noor, Haake, Scott M, Jonasch, Eric, Muir, Alexander, Weiss, Vivian L, Beckermann, Kathryn E, Rathmell, W Kimryn, Rathmell, Jeffrey C

“…Clear cell renal cell carcinoma (ccRCC) is characterized by dysregulated hypoxia signaling and a tumor microenvironment (TME) highly enriched in myeloid and…”
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Author Correction: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity by Bader, Jackie E., Wolf, Melissa M., Lupica-Tondo, Gian Luca, Madden, Matthew Z., Reinfeld, Bradley I., Arner, Emily N., Hathaway, Emma S., Steiner, KayLee K., Needle, Gabriel A., Hatem, Zaid, Landis, Madelyn D., Faneuff, Eden E., Blackman, Amondrea, Wolf, Elysa M., Cottam, Matthew A., Ye, Xiang, Bates, Madison E., Smart, Kyra, Wang, Wenjun, Pinheiro, Laura V., Christofides, Anthos, Smith, DuPreez, Boussiotis, Vassiliki A., Haake, Scott M., Beckermann, Kathryn E., Wellen, Kathryn E., Reinhart-King, Cynthia A., Serezani, C. Henrique, Lee, Cheng-Han, Aubrey, Christa, Chen, Heidi, Rathmell, W. Kimryn, Hasty, Alyssa H., Rathmell, Jeffrey C.

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Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus by Voss, Kelsey, Sewell, Allison E, Krystofiak, Evan S, Gibson-Corley, Katherine N, Young, Arissa C, Basham, Jacob H, Sugiura, Ayaka, Arner, Emily N, Beavers, William N, Kunkle, Dillon E, Dickson, Megan E, Needle, Gabriel A, Skaar, Eric P, Rathmell, W Kimryn, Ormseth, Michelle J, Major, Amy S, Rathmell, Jeffrey C

“…T cells in systemic lupus erythematosus (SLE) exhibit multiple metabolic abnormalities. Excess iron can impair mitochondria and may contribute to SLE. To gain…”
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Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction by Cruz, Victoria H., Arner, Emily N., Wynne, Katherine W., Scherer, Philipp E., Brekken, Rolf A.

“…TANK Binding Kinase 1 (TBK1) has been implicated in the regulation of metabolism through studies with the drug amlexanox, an inhibitor of the IκB kinase…”
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Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer by Cruz, Victoria H, Arner, Emily N, Du, Wenting, Bremauntz, Alberto E, Brekken, Rolf A

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS. Direct inhibition of KRAS through pharmacological means remains a…”
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Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1 by Nie, Minghua, Arner, Emily, Prudden, John, Schaffer, Lana, Head, Steven, Boddy, Michael N

“…Posttranslational modifications (PTMs) provide dynamic regulation of the cellular proteome, which is critical for both normal cell growth and for orchestrating…”
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Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation by Heintzman, Darren R, Sinard, Rachael C, Fisher, Emilie L, Ye, Xiang, Patterson, Andrew R, Elasy, Joel H, Voss, Kelsey, Chi, Channing, Sugiura, Ayaka, Rodriguez-Garcia, Gabriel J, Chowdhury, Nowrin U, Arner, Emily N, Krystoviak, Evan S, Mason, Frank M, Toudji, Yasmine T, Steiner, KayLee K, Khan, Wasay, Olson, Lana M, Jones, Angela L, Hong, Hanna S, Bass, Lindsay, Beier, Katherine L, Deng, Wentao, Lyssiotis, Costas A, Newcomb, Dawn C, Bick, Alexander G, Rathmell, W Kimryn, Wilson, John T, Rathmell, Jeffrey C

“…Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain. We show that moderate-grade fever temperatures (39°C) increased…”
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Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation by Chowdhury, Nowrin U, Cephus, Jacqueline-Yvonne, Henriquez Pilier, Emely, Wolf, Melissa M, Madden, Matthew Z, Kuehnle, Shelby N, McKernan, Kaitlin E, Jennings, Erin Q, Arner, Emily N, Heintzman, Darren R, Chi, Channing, Sugiura, Ayaka, Stier, Matthew T, Voss, Kelsey, Ye, Xiang, Scales, Kennedi L, Krystofiak, Evan S, Gandhi, Vivek D, Guzy, Robert D, Cahill, Katherine N, Sperling, Anne I, Peebles, Jr, R Stokes, Rathmell, Jeffrey C, Newcomb, Dawn C

“…Females have an increased prevalence of many Th17 cell-mediated diseases, including asthma. Androgen signaling decreases Th17 cell-mediated airway…”
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Mutation and lineage lead to organ-specific cancer by Arner, Emily N, Rathmell, W Kimryn

“…[...]BRAF mutations are associated with the skin cancer melanoma, APC mutations are a hallmark of colon cancer, and loss of the gene VHL is a characteristic of…”
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Single-cell transcriptomics of colorectal cancer metastases identifies enrichment for a therapeutically targetable population of TREM2+ macrophages in peritoneal metastases by Cottam, Matthew, Mirza, Muhammad, Arner, Emily, Hatem, Zaid, Shameer, Muhammad, Beckermann, Kathryn, Idrees, Kamran

“…Colorectal cancer (CRC) is recognized as the third most common cancer and the second leading cause of cancer-related mortality globally. The primary driver…”
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Abstract 1033: Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer by Arner, Emily N., Cruz, Victoria H., Du, Wenting, Brekken, Rolf

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS. Direct inhibition of KRAS through pharmacological means remains a…”
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HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma by Bacigalupa, Zachary A, Arner, Emily N, Vlach, Logan M, Wolf, Melissa M, Brown, Whitney A, Krystofiak, Evan S, Ye, Xiang, Hongo, Rachel A, Landis, Madelyn, Amason, Edith K, Beckermann, Kathryn E, Rathmell, W Kimryn, Rathmell, Jeffrey C

“…Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer driven by VHL loss and aberrant HIF-2α signaling. Identifying means to regulate HIF-2α thus has…”
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