Search Results - "Arner, E C"

Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins by Tortorella, M. D., Burn, T. C., Pratta, M. A., Abbaszade, I., Hollis, J. M., Liu, R., Rosenfeld, S. A., Copeland, R. A., Decicco, C. P., Wynn, R., Rockwell, A., Yang, F., Duke, J. L., Solomon, K., George, H., Bruckner, R., Nagase, H., Itoh, Y., Ellis, D. M., Ross, H., Wiswall, B. H., Murphy, K., Hillman, M. C., Hollis, G. F., Newton, R. C., Magolda, R. L., Trzaskos, J. M., Arner, E. C.

“…We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases…”
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Interleukin-1 differentially modulates chondrocyte expression of cyclooxygenase-2 and phospholipase A2 by Lyons-Giordano, B, Pratta, M A, Galbraith, W, Davis, G L, Arner, E C

“…Interleukin-1 beta (IL-1) increases the synthesis of prostaglandins as well as the expression of synovial fluid phospholipase A2 (PLA2) mRNA and activity by…”
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Macrocyclic Amino Carboxylates as Selective MMP-8 Inhibitors by Cherney, Robert J, Wang, Li, Meyer, Dayton T, Xue, Chu-Baio, Wasserman, Zelda R, Hardman, Karl D, Welch, Patty K, Covington, Maryanne B, Copeland, Robert A, Arner, Elizabeth C, DeGrado, William F, Decicco, Carl P

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Intra-articular injection of tumor necrosis factor-α in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation by Malfait, A.M, Tortorella, M, Thompson, J, Hills, R, Meyer, D.M, Jaffee, B.D, Chinn, K, Ghoreishi-Haack, N, Markosyan, S, Arner, E.C

“…Summary Objective To develop an in vivo model for rapid assessment of cartilage aggrecan degradation and its pharmacological modulation. Design Tumor necrosis…”
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Aggrecan Protects Cartilage Collagen from Proteolytic Cleavage by Pratta, Michael A., Yao, Wenqing, Decicco, Carl, Tortorella, Micky D., Liu, Riu-Qin, Copeland, Robert A., Magolda, Ronald, Newton, Robert C., Trzaskos, James M., Arner, Elizabeth C.

“…The matrix components responsible for cartilage mechanical properties, type II collagen and aggrecan, are degraded in osteoarthritis through proteolytic…”
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Interleukin-1 receptor antagonist inhibits proteoglycan breakdown in antigen induced but not polycation induced arthritis in the rabbit by Arner, E C, Harris, R R, DiMeo, T M, Collins, R C, Galbraith, W

“…To compare the alterations in proteoglycan metabolism in antigen induced arthritis and polycation induced arthritis and to determine the involvement of…”
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Expression and regulation of aggrecanase in arthritis: the role of TGF-beta by Yamanishi, Yuji, Boyle, David L, Clark, Melody, Maki, Rich A, Tortorella, Micky D, Arner, Elizabeth C, Firestein, Gary S

“…Aggrecanases are key matrix-degrading enzymes that act by cleaving aggrecan at the Glu(373)-Ala(374) site. While these fragments have been detected in…”
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Brain-enriched Hyaluronan Binding (BEHAB)/Brevican Cleavage in a Glioma Cell Line Is Mediated by a Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) Family Member by Matthews, Russell T., Gary, Sydney C., Zerillo, Cynthia, Pratta, Michael, Solomon, Kimberly, Arner, Elizabeth C., Hockfield, Susan

“…Brain-enriched hyaluronan binding (BEHAB)/brevican is a brain-specific extracellular matrix protein containing a cleavage site between Glu395-Ser396, which…”
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Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) is induced in rabbit articular chondrocytes by cotreatment with interleukin 1 beta and a protein kinase C activator by Ogata, Y, Pratta, M A, Nagase, H, Arner, E C

“…The synthesis of an 88-kDa gelatinolytic enzyme, identified as a zymogen of matrix metalloproteinase (proMMP)-9, was induced in the primary culture of rabbit…”
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Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-α production by Cherney, Robert J., Wang, Li, Meyer, Dayton T., Xue, Chu-Biao, Arner, Elizabeth C., Copeland, Robert A., Covington, Maryanne B., Hardman, Karl D., Wasserman, Zelda R., Jaffee, Bruce D., Decicco, Carl P.

“…Several macrocyclic, hydroxamate derivatives were synthesized and evaluated as inhibitors of matrix metalloproteinases (MMPs) and tumour necrosis factor-α…”
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Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors by Yao, W, Wasserman, Z R, Chao, M, Reddy, G, Shi, E, Liu, R Q, Covington, M B, Arner, E C, Pratta, M A, Tortorella, M, Magolda, R L, Newton, R, Qian, M, Ribadeneira, M D, Christ, D, Wexler, R R, Decicco, C P

“…A pharmacophore model of the P1' site, specific for aggrecanase, was defined using the specificity studies of the matrix metalloproteinases and the similar…”
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Effect of animal age and chronicity of interleukin-1 exposure on cartilage proteoglycan depletion in vivo by Arner, E C

“…Rheumatoid arthritis and osteoarthritis are characterized by an early depletion of cartilage proteoglycans, which leads to a decrease in cartilage…”
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A high-throughput assay for stromelysin using a casein-resorufin substrate by Tortorella, M D, Arner, E C

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Effect of ebselen on IL-1-induced alterations in cartilage metabolism by Pratta, M A, Ackerman, N R, Arner, E C

“…To evaluate the effect of the antioxidant-like anti-inflammatory agent, ebselen, on cartilage proteoglycan degradation and to determine whether its cartilage…”
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Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity by Arner, E C, Pratta, M A, Trzaskos, J M, Decicco, C P, Tortorella, M D

“…A method was developed for generating soluble, active "aggrecanase" in conditioned media from interleukin-1-stimulated bovine nasal cartilage cultures. Using…”
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Age-related Changes in Aggrecan Glycosylation Affect Cleavage by Aggrecanase by Pratta, Michael A., Tortorella, Micky D., Arner, Elizabeth C.

“…Aggrecan degradation involves proteolytic cleavage of the core protein within the interglobular domain. Because aggrecan is highly glycosylated with…”
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Modification of red cell membrane structure by cholesterol-rich lipid dispersions. A model for the primary spur cell defect by Cooper, R A, Arner, E C, Wiley, J S, Shattil, S J

“…Cholesterol-rich membranes are the hallmark of "spur" red cells. Spur cells accumulate cholesterol from cholesterol-rich serum lipoproteins. Previous studies…”
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Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase by Arner, E C, Hughes, C E, Decicco, C P, Caterson, B, Tortorella, M D

“…To evaluate the relationship between specific cleavage of aggrecan at the Glu373-Ala374 'aggrecanase' site and degradation and release of proteoglycan…”
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Chondrocyte Extracellular Matrix Synthesis and Turnover Are Influenced by Static Compression in a New Alginate Disk Culture System by Ragan, Paula M., Chin, Vicki I., Hung, Han-Hwa K., Masuda, Koichi, Thonar, Eugene J.-M.A., Arner, Elizabeth C., Grodzinsky, Alan J., Sandy, John D.

“…The goal of this study was to examine the effects of mechanical compression on chondrocyte biosynthesis of extracellular matrix (ECM) components during culture…”
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The effects of interleukin-1 on the expression of thrombospondin and fibronectin by rabbit articular chondrocytes by Lyons-Giordano, B, Kefalides, N A, Brinker, J M, Pratta, M A, Arner, E C

“…Studies to evaluate the effects of recombinant interleukin-1 beta (IL-1) on the expression of matrix proteins by rabbit articular chondrocytes were conducted…”
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