Search Results - "Arne Yndestad"

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury by Sandanger, Øystein, Ranheim, Trine, Vinge, Leif Erik, Bliksøen, Marte, Alfsnes, Katrine, Finsen, Alexandra V, Dahl, Christen P, Askevold, Erik T, Florholmen, Geir, Christensen, Geir, Fitzgerald, Katherine A, Lien, Egil, Valen, Guro, Espevik, Terje, Aukrust, Pål, Yndestad, Arne

“…Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) is considered necessary for initiating a profound sterile inflammatory…”
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Inflammatory cytokines in heart failure: mediators and markers by Gullestad, Lars, Ueland, Thor, Vinge, Leif Erik, Finsen, Alexandra, Yndestad, Arne, Aukrust, Pål

“…Evidence from both experimental and clinical trials indicates that inflammatory mediators are of importance in the pathogenesis of chronic heart failure (HF)…”
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The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis by Hovland, Anders, Jonasson, Lena, Garred, Peter, Yndestad, Arne, Aukrust, Pål, Lappegård, Knut T, Espevik, Terje, Mollnes, Tom E

“…Abstract Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated…”
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Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication by Lauritzen, Knut H, Olsen, Maria Belland, Ahmed, Mohammed Shakil, Yang, Kuan, Rinholm, Johanne Egge, Bergersen, Linda H, Esbensen, Qin Ying, Sverkeli, Lars Jansen, Ziegler, Mathias, Attramadal, Håvard, Halvorsen, Bente, Aukrust, Pål, Yndestad, Arne

“…Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD + ) as energy source. Prolonged…”
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NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction by Sokolova, Marina, Sahraoui, Afaf, Høyem, Merete, Øgaard, Jonas, Lien, Egil, Aukrust, Pål, Yndestad, Arne, Ranheim, Trine, Scholz, Hanne

“…Inflammasomes are multiprotein inflammatory platforms that induce caspase-1 activation and subsequently interleukin (IL)-1β and IL-18 processing. The NLRP3…”
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NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis by Paramel Varghese, Geena, Folkersen, Lasse, Strawbridge, Rona J., Halvorsen, Bente, Yndestad, Arne, Ranheim, Trine, Krohg‐Sørensen, Kirsten, Skjelland, Mona, Espevik, Terje, Aukrust, Pål, Lengquist, Mariette, Hedin, Ulf, Jansson, Jan‐Håkan, Fransén, Karin, Hansson, Göran K., Eriksson, Per, Sirsjö, Allan

“…Background The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)‐1β and IL‐18 cytokine processing complex that is activated in…”
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NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet by Sokolova, Marina, Yang, Kuan, Hansen, Simen H., Louwe, Mieke C., Kummen, Martin, Hov, Johannes E. R., Sjaastad, Ivar, Berge, Rolf K., Halvorsen, Bente, Aukrust, Pål, Yndestad, Arne, Ranheim, Trine

“…Obesity-related diseases (e.g. type 2 diabetes mellitus and cardiovascular disorders) represent an increasing health problem worldwide. NLRP3 inflammasome…”
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S775 Major Cardiovascular Adverse Events by Baseline Cardiovascular Risk Stratification in Patients With Ulcerative Colitis Treated With Tofacitinib: Data From the OCTAVE Clinical Program by Schreiber, Stefan, Rubin, David T., Ng, Siew C., Modesto, Irene, Guo, Xiang, Su, Chinyu, Kwok, Kenneth K., Jo, Hyejin, Chen, Yan, Yndestad, Arne, Reinisch, Walter, Dubinsky, Marla C.

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Association between baseline cardiovascular risk and incidence rates of major adverse cardiovascular events and malignancies in patients with psoriatic arthritis and psoriasis receiving tofacitinib by Kristensen, Lars E., Strober, Bruce, Poddubnyy, Denis, Leung, Ying-Ying, Jo, Hyejin, Kwok, Kenneth, Vranic, Ivana, Fleishaker, Dona L., Fallon, Lara, Yndestad, Arne, Gladman, Dafna D.

“…Background: Tofacitinib is a Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA) and has been investigated for psoriasis (PsO). Objectives:…”
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Chronic HIV Infection Increases Monocyte NLRP3 Inflammasome-Dependent IL-1α and IL-1β Release by Hoel, Hedda, Dahl, Tuva Børresdatter, Yang, Kuan, Skeie, Linda Gail, Michelsen, Annika Elisabet, Ueland, Thor, Damås, Jan Kristian, Dyrhol-Riise, Anne Ma, Fevang, Børre, Yndestad, Arne, Aukrust, Pål, Trøseid, Marius, Sandanger, Øystein

“…Antiretroviral treatment (ART) has converted HIV from a lethal disease to a chronic condition, yet co-morbidities persist. Incomplete immune recovery and…”
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Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice by Cero, Fadila Telarevic, Hillestad, Vigdis, Sjaastad, Ivar, Yndestad, Arne, Aukrust, Pål, Ranheim, Trine, Lunde, Ida Gjervold, Olsen, Maria Belland, Lien, Egil, Zhang, Lili, Haugstad, Solveig Bjærum, Løberg, Else Marit, Christensen, Geir, Larsen, Karl-Otto, Skjønsberg, Ole Henning

“…Pulmonary hypertension is a serious condition that can lead to premature death. The mechanisms involved are incompletely understood although a role for the…”
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Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies by Haukeland, John Willy, Dahl, Tuva B, Yndestad, Arne, Gladhaug, Ivar P, Løberg, Else Marit, Haaland, Terese, Konopski, Zbigniew, Wium, Cecilie, Aasheim, Erlend T, Johansen, Odd Erik, Aukrust, Pål, Halvorsen, Bente, Birkeland, Kåre I

“…ObjectiveFetuin A has been associated with insulin resistance and the metabolic syndrome. We therefore explored the role of fetuin A in nonalcoholic fatty…”
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Rosuvastatin alters the genetic composition of the human gut microbiome by Kummen, Martin, Solberg, Ole Geir, Storm-Larsen, Christopher, Holm, Kristian, Ragnarsson, Asgrimur, Trøseid, Marius, Vestad, Beate, Skårdal, Rita, Yndestad, Arne, Ueland, Thor, Svardal, Asbjørn, Berge, Rolf K., Seljeflot, Ingebjørg, Gullestad, Lars, Karlsen, Tom H., Aaberge, Lars, Aukrust, Pål, Hov, Johannes R.

“…The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with the effect of statins. Yet, our knowledge…”
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Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts by Sokolova, Marina, Vinge, Leif Erik, Alfsnes, Katrine, Olsen, Maria Belland, Eide, Lars, Kaasbøll, Ole Jørgen, Attramadal, Håvard, Torp, May-Kristin, Fosshaug, Linn E., Rashidi, Azita, Lien, Egil, Finsen, Alexandra Vanessa, Sandanger, Øystein, Aukrust, Pål, Ranheim, Trine, Yndestad, Arne

“…Palmitate triggers inflammatory responses in several cell types, but its effects on cardiac fibroblasts are at present unknown. The aims of the study were to…”
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Chemokines and Cardiovascular Risk by Aukrust, Pål, Halvorsen, Bente, Yndestad, Arne, Ueland, Thor, Øie, Erik, Otterdal, Kari, Gullestad, Lars, Damås, Jan K

“…Based on the importance of inflammation in atherogenesis, recent work has focused on whether plasma markers of inflammation can noninvasively diagnose and…”
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Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency by Macpherson, Magnhild E., Halvorsen, Bente, Yndestad, Arne, Ueland, Thor, Mollnes, Tom E., Berge, Rolf K., Rashidi, Azita, Otterdal, Kari, Gregersen, Ida, Kong, Xiang Y., Holven, Kirsten B., Aukrust, Pål, Fevang, Børre, Jørgensen, Silje F.

“…Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent…”
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IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria by Otterdal, Kari, Berg, Aase, Michelsen, Annika E, Yndestad, Arne, Patel, Sam, Gregersen, Ida, Halvorsen, Bente, Ueland, Thor, Langeland, Nina, Aukrust, Pål

“…Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes…”
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Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation by Gregersen, Ida, Sandanger, Øystein, Askevold, Erik T, Sagen, Ellen Lund, Yang, Kuan, Holm, Sverre, Pedersen, Turid M, Skjelland, Mona, Krohg-Sørensen, Kirsten, Hansen, Trond Vidar, Dahl, Tuva Børresdatter, Otterdal, Kari, Espevik, Terje, Aukrust, Pål, Yndestad, Arne, Halvorsen, Bente

“…Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role in atherosclerosis is unclear. In this study we investigated the…”
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Increased circulating mitochondrial DNA after myocardial infarction by Bliksøen, Marte, Mariero, Lars Henrik, Ohm, Ingrid Kristine, Haugen, Fred, Yndestad, Arne, Solheim, Svein, Seljeflot, Ingebjørg, Ranheim, Trine, Andersen, Geir Øystein, Aukrust, Pål, Valen, Guro, Vinge, Leif Erik

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Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis by Niyonzima, Nathalie, Bakke, Siril S., Gregersen, Ida, Holm, Sverre, Sandanger, Øystein, Orrem, Hilde L., Sporsheim, Bjørnar, Ryan, Liv, Kong, Xiang Yi, Dahl, Tuva Børresdatter, Skjelland, Mona, Sørensen, Kirsten Krohg, Rokstad, Anne Mari, Yndestad, Arne, Latz, Eicke, Gullestad, Lars, Andersen, Geir Ø., Damås, Jan Kristian, Aukrust, Pål, Mollnes, Tom E., Halvorsen, Bente, Espevik, Terje

“…During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT,…”
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