Search Results - "Arndt, Tanja"

Correction to: Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat by Jörns, Anne, Arndt, Tanja, Yamada, Shinichiro, Ishikawa, Daichi, Yoshimoto, Toshiaki, Terbish, Taivankhuu, Wedekind, Dirk, van der Meide, Peter H., Lenzen, Sigurd

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Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat by Jörns, Anne, Arndt, Tanja, Yamada, Shinichiro, Ishikawa, Daichi, Yoshimoto, Toshiaki, Terbish, Taivankhuu, Wedekind, Dirk, van der Meide, Peter H., Lenzen, Sigurd

“…Proinflammatory cytokines released from the pancreatic islet immune cell infiltrate in type 1 diabetes (T1D) cause insulinopenia as a result of severe beta…”
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A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat by Arndt, Tanja, Jörns, Anne, Weiss, Heike, Tiedge, Markus, Hedrich, Hans-Jürgen, Lenzen, Sigurd, Wedekind, Dirk

“…The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM), which arose through a spontaneous mutation within the MHC-congenic inbred…”
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Diabetes Prevention by Immunomodulatory FTY720 Treatment in the LEW.1AR1-iddm Rat Despite Immune Cell Activation by Jörns, Anne, Rath, Klaus Jan, Terbish, Taivankhuu, Arndt, Tanja, Meyer zu Vilsendorf, Andreas, Wedekind, Dirk, Hedrich, Hans-Jürgen, Lenzen, Sigurd

“…The prevention of diabetes by the immunomodulatory agent FTY720 (fingolimod) was studied in the LEW.1AR1-iddm (IDDM) rat, an animal model of human type 1…”
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Rat Models of Human Type 1 Diabetes by Lenzen, Sigurd, Arndt, Tanja, Elsner, Matthias, Wedekind, Dirk, Jörns, Anne

“…Rat models of human type 1 diabetes have been shown to be of great importance for the elucidation of the mechanisms underlying the development of autoimmune…”
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Changes in immune cell frequencies in primary and secondary lymphatic organs of LEW.1AR1-iddm rats, a model of human type 1 diabetes compared to other MHC congenic LEW inbred strains by Arndt, Tanja, Jörns, Anne, Wedekind, Dirk

“…The LEW.1AR1- iddm rat is an animal model of human type 1 diabetes, which arose through a spontaneous mutation in the Dock8 gene within the MHC congenic…”
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Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes by Jörns, Anne, Arndt, Tanja, zu Vilsendorf, Andreas Meyer, Klempnauer, Jürgen, Wedekind, Dirk, Hedrich, Hans-Jürgen, Marselli, Lorella, Marchetti, Piero, Harada, Nagakatsu, Nakaya, Yutaka, Wang, Gen-Sheng, Scott, Fraser W., Gysemans, Conny, Mathieu, Chantal, Lenzen, Sigurd

“…Aims/hypothesis Research on the pathogenesis of type 1 diabetes relies heavily on good animal models. The aim of this work was to study the translational value…”
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TNF-α Antibody Therapy in Combination With the T-Cell-Specific Antibody Anti-TCR Reverses the Diabetic Metabolic State in the LEW.1AR1-iddm Rat by Jörns, Anne, Ertekin, Ümüs Gül, Arndt, Tanja, Terbish, Taivankhuu, Wedekind, Dirk, Lenzen, Sigurd

“…Anti-tumor necrosis factor-α (TNF-α) therapy (5 mg/kg body weight), alone or combined with the T-cell-specific antibody anti-T-cell receptor (TCR) (0.5 mg/kg…”
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TNF-[Alpha] Antibody Therapy in Combination With the T-Cell-Specific Antibody Anti-TCR Reverses the Diabetic Metabolic State in the LEW.1AR1-iddm Rat by Jörns, Anne, Ertekin, Ümüs Gül, Arndt, Tanja, Terbish, Taivankhuu, Wedekind, Dirk, Lenzen, Sigurd

“…Anti-tumor necrosis factor-α (TNF-α) therapy (5 mg/kg body weight), alone or combined with the T-cell-specific antibody anti-T-cell receptor (TCR) (0.5 mg/kg…”
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A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes by Arndt, Tanja, Wedekind, Dirk, Jörns, Anne, Tsiavaliaris, Georgios, Cuppen, Edwin, Hedrich, Hans-Jürgen, Lenzen, Sigurd

“…Aims/hypothesis The LEW.1AR1- iddm rat, an animal model of human type 1 diabetes, arose through a spontaneous mutation within the inbred strain LEW.1AR1. A…”
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Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings by Tsikas, Dimitrios, Hanff, Erik, Bollenbach, Alexander, Kruger, Ruan, Pham, Vu Vi, Chobanyan-Jürgens, Kristine, Wedekind, Dirk, Arndt, Tanja, Jörns, Anne, Berbée, Jimmy F. P., Princen, Hans M. G., Lücke, Thomas, Mariotti, François, Huneau, Jean-François, Ückert, Stefan, Frölich, Jürgen C., Lenzen, Sigurd

“…We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO 2 − ), an abundant reservoir of nitric oxide (NO)…”
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Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes by Jörns, Anne, Akin, Muharrem, Arndt, Tanja, Terbish, Taivankhuu, zu Vilsendorf, Andreas Meyer, Wedekind, Dirk, Hedrich, Hans-Jürgen, Lenzen, Sigurd

“…The therapeutic capacity of an antibody directed against the T cell receptor (anti-TCR) of the TCR/CD3 complex alone or in combination with fingolimod (FTY720)…”
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Kinetics of CD8+ effector T cell responses and induced CD4+ regulatory T cell responses during Friend retrovirus infection by Zelinskyy, Gennadiy, Kraft, Anke R. M., Schimmer, Simone, Arndt, Tanja, Dittmer, Ulf

“…Cytolytic CD8+ T cells are critical for the control of acute Friend virus (FV) infection yet they fail to completely eliminate the virus during chronic…”
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A Variable CD3.sup.+ T-Cell Frequency in Peripheral Blood Lymphocytes Associated with Type 1 Diabetes Mellitus Development in the LEW.1AR1-iddm Rat by Arndt, Tanja, Jörns, Anne, Weiss, Heike, Tiedge, Markus, Hedrich, Hans-Jürgen, Lenzen, Sigurd, Wedekind, Dirk

“…Purpose The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM), which arose through a spontaneous mutation within the MHC-congenic…”
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Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by [beta] cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes by Jörns, Anne, Akin, Muharrem, Arndt, Tanja, Terbish, Taivankhuu, Zu Vilsendorf, Andreas Meyer, Wedekind, Dirk, Hedrich, Hans-jürgen, Lenzen, Sigurd

“…Issue Title: Targeted therapies in cancer and mechanisms of resistance The therapeutic capacity of an antibody directed against the T cell receptor (anti-TCR)…”
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Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line by Thomas, Heike, Senkel, Sabine, Erdmann, Silke, Arndt, Tanja, Turan, Gülüzar, Klein-Hitpass, Ludger, Ryffel, Gerhart U

“…Using the rat insulinoma cell line INS-1 we generated beta-cell clones that are most efficient for gene transfer, as they contain an FRT site for Flp…”
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Results, meta-analysis and a first evaluation of U NOx R, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings by Tsikas, Dimitrios, Hanff, Erik, Bollenbach, Alexander, Kruger, Ruan, Pham, Vu Vi, Chobanyan-Jürgens, Kristine, Wedekind, Dirk, Arndt, Tanja, Jörns, Anne, Berbée, Jimmy F P, Princen, Hans M G, Lücke, Thomas, Mariotti, François, Huneau, Jean-François, Ückert, Stefan, Frölich, Jürgen C, Lenzen, Sigurd

“…We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO ), an abundant reservoir of nitric oxide (NO) in…”
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Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4α and HNF1β in a pancreatic β-cell line by Thomas, Heike, Senkel, Sabine, Erdmann, Silke, Arndt, Tanja, Turan, Gülüzar, Klein-Hitpass, Ludger, Ryffel, Gerhart U.

“…Using the rat insulinoma cell line INS-1 we generated β-cell clones that are most efficient for gene transfer, as they contain an FRT site for Flp…”
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A Variable CD3+ T-Cell Frequency in Peripheral Blood Lymphocytes Associated with Type 1 Diabetes Mellitus Development in the LEW.1AR1-iddm Rat. e64305 by Arndt, Tanja, Jorns, Anne, Weiss, Heike, Tiedge, Markus, Hedrich, Hans-Juergen, Lenzen, Sigurd, Wedekind, Dirk

“…Purpose The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM), which arose through a spontaneous mutation within the MHC-congenic…”
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mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1 by Weiss, Heike, Arndt, Tanja, Jörns, Anne, Lenzen, Sigurd, Cuppen, Edwin, Hedrich, Hans J, Tiedge, Markus, Wedekind, Dirk

“…The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM) with an autosomal recessive mode of inheritance. T1DM susceptibility loci…”
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