Search Results - "Arnau, Elena"

Antioxidant Activity and Skin Sensitization of Eugenol and Isoeugenol: Two Sides of the Same Coin? by Port-Lougarre, Yannick, Gourlaouen, Christophe, Vileno, Bertrand, Giménez-Arnau, Elena

“…Eugenol and isoeugenol are well acknowledged to possess antioxidant and thus cytoprotective activities. Yet both compounds are also important skin sensitizers,…”
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Probing skin photoallergens in reconstructed human epidermis: An EPR spin trapping investigation by Port-Lougarre, Yannick, Voegeli, Guillaume, Vileno, Bertrand, Giménez-Arnau, Elena

“…Photoallergic contact dermatitis is a skin disease caused by combined exposure to photoreactive chemicals and sunlight. Exposure to allergens and the risk of…”
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Electron paramagnetic resonance and spin trapping to detect free radicals from allergenic hydroperoxides in contact with the skin: From the molecule to the tissue by Vileno, Bertrand, Port‐Lougarre, Yannick, Giménez‐Arnau, Elena

“…A major research topic consists of revealing the contribution of radical‐mediated reactions in dermatological diseases related to xenobiotic‐induced stress to…”
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Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens by Bonefeld, Charlotte M., Geisler, Carsten, Gimenéz‐Arnau, Elena, Lepoittevin, Jean‐Pierre, Uter, Wolfgang, Johansen, Jeanne D.

“…Summary Allergic contact dermatitis is one of the most frequent forms of skin inflammation. Very often, we are exposed to mixtures of allergens with varying…”
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Autoxidized citronellol: Free radicals as potential sparkles to ignite the fragrance induced skin sensitizing pathway by Sahli, Fatma, Vileno, Bertrand, Gourlaouen, Christophe, Giménez-Arnau, Elena

“…Citronellol, one of the most used fragrance compounds worldwide, is one ingredient of Fragrance Mix II used to assess skin allergy to fragrances in dermatitis…”
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Limonene and linalool hydroperoxides review: Pros and cons for routine patch testing by Ogueta, Isabel A, Brared Christensson, Johanna, Giménez‐Arnau, Elena, Brans, Richard, Wilkinson, Mark, Stingeni, Luca, Foti, Caterina, Aerts, Olivier, Svedman, Cecilia, Gonçalo, Margarida, Giménez‐Arnau, Ana

“…Limonene and linalool are among the most common fragrance terpenes used in everyday products. They are pre‐haptens, forming hydroperoxides (Lim‐OOHs, Lin‐OOHs)…”
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Synthesis and In Situ Behavior of 1,4- and 2,5‑(13C) Isotopomers of p-Phenylenediamine in Reconstructed Human Epidermis Using High Resolution Magic Angle Spinning NMR by Srour, Hassan, Gosset, Alexis, Moussallieh, François-Marie, Elbayed, Karim, Giménez-Arnau, Elena, Lepoittevin, Jean-Pierre

“…p-Phenylenediamine (PPD) has been classified as a strong skin allergen, but when it comes to toxicological concerns, benzoquinone diamine (BQDI), the primary…”
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Isothiazolinones are still widely used in paints purchased in five European countries: a follow‐up study by Thomsen, Andreas V., Schwensen, Jakob F., Bossi, Rossana, Banerjee, Piu, Giménez‐Arnau, Elena, Lepoittevin, Jean‐Pierre, Lidén, Carola, Uter, Wolfgang, White, Ian R., Johansen, Jeanne D.

“…Summary Background An increasing incidence of contact allergy to methylisothiazolinone (MI) has been seen, caused, in particular, by cosmetic products and…”
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Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five European countries by Schwensen, Jakob F., Lundov, Michael D., Bossi, Rossana, Banerjee, Piu, Gimenez-Arnau, Elena, Lepoittevin, Jean-Pierre, Lidén, Carola, Uter, Wolfgang, Yazar, Kerem, White, Ian R., Johansen, Jeanne D.

“…Summary Background In view of the current epidemic of contact allergy to methylisothiazolinone (MI), it is important to clarify the extent of use of MI and…”
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In Situ Alkylation of Reconstructed Human Epidermis by Methyl Methanesulfonate: A Quantitative HRMAS NMR Chemical Reactivity Mapping by Srour, Hassan, Moussallieh, François-Marie, Elbayed, Karim, Giménez-Arnau, Elena, Lepoittevin, Jean-Pierre

“…Allergic contact dermatitis (ACD) is a reaction of the immune system resulting from skin sensitization to an exogenous hazardous chemical and leading to the…”
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Sensitization potential and potency of terpene hydroperoxides in the cocultured activation test method by Hennen, Jennifer, Silva e Sousa, Marta, Sahli, Fatma, Lichter, Jutta, Lepoittevin, Jean‐Pierre, Giménez‐Arnau, Elena, Blömeke, Brunhilde

“…Background Positive patch test reactions to mixtures of oxidized terpenes containing allergenic hydroperoxides are frequently reported. However, human…”
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Mechanistic Insights on Skin Sensitization to Linalool Hydroperoxides: EPR Evidence on Radical Intermediates Formation in Reconstructed Human Epidermis and 13C NMR Reactivity Studies with Thiol Residues by Kuresepi, Salen, Vileno, Bertrand, Lepoittevin, Jean-Pierre, Giménez-Arnau, Elena

“…Linalool is one of the most commonly used fragrance terpenes in consumer products. While pure linalool is considered as non-allergenic because it has a very…”
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Exposure source for skin sensitizing hydroperoxides of limonene and linalool remains elusive: An analytical market surveillance by Natsch, Andreas, Nägelin, Marco, Leijs, Hans, van Strien, Michel, Giménez-Arnau, Elena, Vey, Matthias, González, Cecile

“…Positive patch test reactions of dermatological patients to oxidized samples of linalool and limonene are frequently reported. The sensitizing ingredients in…”
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Chemical Compounds Responsible for Skin Allergy to Complex Mixtures: How to Identify Them? by Giménez-Arnau, Elena

“…In the cosmetics industry, various natural complex mixtures such as botanical extracts and essential oils are used. In addition, finished consumer products may…”
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Is it possible to assess the allergenicity of mixtures based on in chemico methods? Preliminary results on common fragrance aldehydes by Lang, Matthieu, Giménez‐Arnau, Elena, Lepoittevin, Jean‐Pierre

“…Most perfume compositions and cosmetics contain mixtures of fragrance ingredients, synthetic or extracted from natural sources. Many of these are known to be…”
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Bikini textile contact dermatitis: A Sherlockian approach revealing 2,4‐dichlorophenol as a potential textile contact allergen by Pesqué, David, March‐Rodriguez, Álvaro, Dahlin, Jakob, Isaksson, Marléne, Pujol, Ramon M., Giménez‐Arnau, Elena, Giménez‐Arnau, Ana M.

“…Background Different textile constituents may act as allergens and/or irritants and provoke textile contact dermatitis (TCD). Objectives To report a case of…”
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Synthesis of Allylic Hydroperoxides and EPR Spin-Trapping Studies on the Formation of Radicals in Iron Systems as Potential Initiators of the Sensitizing Pathway by Kao, Dany, Chaintreau, Alain, Lepoittevin, Jean-Pierre, Giménez-Arnau, Elena

“…Many terpenes used as fragrance compounds autoxidize when exposed to air, forming allylic hydroperoxides that have the potential to be skin contact allergens…”
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In situ chemical behaviour of methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) in reconstructed human epidermis: a new approach to the cross-reactivity issue by Debeuckelaere, Camille, Moussallieh, François-Marie, Elbayed, Karim, Namer, Izzie-Jacques, Berl, Valérie, Giménez-Arnau, Elena, Lepoittevin, Jean-Pierre

“…Summary Background Methylisothiazolinone (MI) [with methylchloroisothiazolinone (MCI) in a ratio of 1:3, a well‐recognized allergenic preservative] was…”
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Editor’s Highlight: Fragrance Allergens Linalool and Limonene Allylic Hydroperoxides in Skin Allergy: Mechanisms of Action Focusing on Transcription Factor Nrf2 by Raffalli, Chloé, Clouet, Elodie, Kuresepi, Salen, Damiens, Marie-Hélène, Lepoittevin, Jean-Pierre, Pallardy, Marc, Ferret, Pierre-Jacques, Giménez-Arnau, Elena, Kerdine-Römer, Saadia

“…Abstract Allergic contact dermatitis is regarded as the most frequent expression of immunotoxicity in humans. Many odorant terpenes commonly used in fragrance…”
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Enhanced sensitization and elicitation responses caused by mixtures of common fragrance allergens by Bonefeld, Charlotte Menné, Nielsen, Morten Milek, Rubin, Ingrid Maria Cecilia, Vennegaard, Marie Torp, Dabelsteen, Sally, Gimenéz-Arnau, Elena, Lepoittevin, Jean-Pierre, Geisler, Carsten, Johansen, Jeanne Duus

“…Background. Perfumes are complex mixtures composed of many fragrance ingredients, many of which are known to be only weak allergens when tested individually…”
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