Search Results - "Arnaiz, Cayetana"
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Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs
Published in The Journal of biological chemistry (08-02-2019)“…Lipid transport is an essential process with manifest importance to human health and disease. Phospholipid flippases (P4-ATPases) transport lipids across the…”
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SSNA1 stabilizes dynamic microtubules and detects microtubule damage
Published in eLife (31-12-2021)“…Sjögren's syndrome nuclear autoantigen-1 (SSNA1/NA14) is a microtubule-associated protein with important functions in cilia, dividing cells, and developing…”
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Life is pain: Fibromyalgia as a nexus of multiple liability distributions
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01-10-2023)“…Fibromyalgia is a complex disease of unclear etiology that is complicated by difficulties in diagnosis, treatment, and clinical heterogeneity. To clarify this…”
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DYRK1A Regulates the Bidirectional Axonal Transport of APP in Human-Derived Neurons
Published in The Journal of neuroscience (17-08-2022)“…triplication in Down's syndrome and its overexpression in Alzheimer's disease suggest a role for increased DYRK1A activity in the abnormal metabolism of APP…”
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SSNA1 stabilizes dynamic microtubules and detects microtubule damage
Published in Biophysical journal (11-02-2022)Get full text
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APP mutations give rise to redox related mitochondrial alterations
Published in Free radical biology & medicine (20-08-2022)Get full text
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Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli
Published in Cell reports (Cambridge) (19-04-2022)“…Microvilli are conserved actin-based surface protrusions that have been repurposed throughout evolution to fulfill diverse cell functions. In the case of…”
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Mitochondrial vulnerability to oxidation in human brain organoids modelling Alzheimer's disease
Published in Free radical biology & medicine (01-11-2023)“…Reactive Oxygen Species (ROS) and mitochondrial dysfunction are implicated in the pathogenesis of Alzheimer's disease (AD), a common neurodegenerative disorder…”
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Swedish Alzheimer’s disease variant perturbs activity of retrograde molecular motors and causes widespread derangement of axonal transport pathways
Published in The Journal of biological chemistry (01-04-2024)“…Experimental studies in flies, mice, and humans suggest a significant role of impaired axonal transport in the pathogenesis of Alzheimer’s disease (AD). The…”
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