Search Results - "Armstrong, Scott R"

Concomitant Angiotensin AT1 Receptor Antagonism and Neprilysin Inhibition Produces Omapatrilat-like Antihypertensive Effects Without Promoting Tracheal Plasma Extravasation in the Rat by Hegde, Laxminarayan G, Yu, Cecile, Renner, Travis, Thibodeaux, Harold, Armstrong, Scott R, Park, Timothy, Cheruvu, Madhavi, Olsufka, Rachael, Sandvik, Erik R, Lane, Cassie E, Budman, Joe, Hill, Craig M, Klein, Uwe, Hegde, Sharath S

“…Dual inhibition of angiotensin-converting enzyme (ACE) and neprilysin (NEP) by drugs such as omapatrilat produces superior antihypertensive efficacy but cause…”
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Discovery of Axelopran (TD-1211): A Peripherally Restricted μ‑Opioid Receptor Antagonist by Long, Daniel D, Armstrong, Scott R, Beattie, David T, Campbell, Christina B, Church, Timothy J, Colson, Pierre-Jean, Dalziel, Sean M, Jacobsen, John R, Jiang, Lan, Obedencio, Glenmar P, Rapta, Miroslav, Saito, Daisuke, Stergiades, Ioanna, Tsuruda, Pamela R, Van Dyke, Priscilla M, Vickery, Ross G

“…The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and…”
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Discovery of TD-8954, a clinical stage 5-HT4 receptor agonist with gastrointestinal prokinetic properties by McKinnell, R. Murray, Armstrong, Scott R., Beattie, David T., Fatheree, Paul R., Long, Daniel D., Marquess, Daniel G., Shaw, Jeng-Pyng, Vickery, Ross G.

“…The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the…”
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The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist by Tsuruda, Pamela R., Vickery, Ross G., Long, Daniel D., Armstrong, Scott R., Beattie, David T.

“…The clinical efficacy of opioid receptor antagonists for the treatment of opioid-induced constipation (OIC) is established. Peripherally selective antagonists…”
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The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity by Armstrong, Scott R., Campbell, Christina B., Richardson, Carrie L., Vickery, Ross G., Tsuruda, Pamela R., Long, Daniel D., Hegde, Sharath S., Beattie, David T.

“…The in vivo preclinical pharmacodynamic profile of TD-1211, a selective opioid receptor antagonist currently under development for the treatment of…”
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Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT4 receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation by Long, Daniel D., Armstrong, Scott R., Beattie, David T., Choi, Seok-Ki, Fatheree, Paul R., Gendron, Roland A.L., Genov, Daniel, Goldblum, Adam A., Humphrey, Patrick P., Jiang, Lan, Marquess, Daniel G., Shaw, Jeng-Pyng, Smith, Jacqueline A.M., Turner, S. Derek, Vickery, Ross G.

“…Utilization of Theravance’s multivalent approach to drug discovery towards 5-HT4 receptor agonists with a focus on identification of neutral (non-charged at…”
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The Pharmacology of TD-8954, a Potent and Selective 5-HT4 Receptor Agonist with Gastrointestinal Prokinetic Properties by Beattie, David T., Armstrong, Scott R., Vickery, Ross G., Tsuruda, Pamela R., Campbell, Christina B., Richardson, Carrie, McCullough, Julia L., Daniels, Oranee, Kersey, Kathryn, Li, Yu-Ping, Kim, Karl H. S.

“…This study evaluated the in vitro and in vivo pharmacological properties of TD-8954, a potent and selective 5-HT 4 receptor agonist. TD-8954 had high affinity…”
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Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: Clinical compound TD-2749 by Long, Daniel D., Armstrong, Scott R., Beattie, David T., Choi, Seok-Ki, Fatheree, Paul R., Gendron, Roland A.L., Goldblum, Adam A., Humphrey, Patrick P., Marquess, Daniel G., Shaw, Jeng-Pyng, Smith, Jacqueline A.M., Derek Turner, S., Vickery, Ross G.

“…Further application of our multivalent approach to drug discovery directed to 5-HT4 receptor agonists is described. Optimization of the linker and secondary…”
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A Multivalent Approach to the Design and Discovery of Orally Efficacious 5-HT4 Receptor Agonists by McKinnell, R. Murray, Armstrong, Scott R, Beattie, David T, Choi, Seok-Ki, Fatheree, Paul R, Gendron, Roland A. L, Goldblum, Adam, Humphrey, Patrick P, Long, Daniel D, Marquess, Daniel G, Shaw, J. P, Smith, Jacqueline A. M, Turner, S. Derek, Vickery, Ross G

“…5-HT4 receptor agonists such as tegaserod have demonstrated efficacy in the treatment of constipation predominant irritable bowel syndrome (IBS-C), a highly…”
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Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist by McNamara, Alexander, Pulido-Rios, Maria Teresa, Sweazey, Shelley, Obedencio, Glenmar P., Thibodeaux, Harold, Renner, Travis, Armstrong, Scott R., Steinfeld, Tod, Hughes, Adam D., Wilson, Richard D., Jasper, Jeffrey R., Mammen, Mathai, Hegde, Sharath S.

“…Existing antimuscarinic drugs for overactive bladder have high affinity for M 3/M 1 muscarinic receptors and consequently produce M 3/M 1-mediated adverse…”
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S1672 TD-8954 Is a Highly Potent and Selective 5-HT4 Receptor Agonist with Potential Utility in Disorders of Reduced Gastrointestinal Motility by Beattie, David T, Vickery, Ross G, Armstrong, Scott R, Ropenga, Anna, Cuthbert, Alan W, Humphrey, Patrick P

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Measurement of 5-HT4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat by Armstrong, Scott R, McCullough, Julia L, Beattie, David T

“…In vitro studies have demonstrated a 5-HT4 receptor-mediated relaxation of the pre-contracted rat esophagus. However, it is unclear whether 5-HT4 receptor…”
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Pharmacological analysis of the interaction of antimuscarinic drugs at M2 and M3 muscarinic receptors in vivo using the pithed rat assay by Armstrong, Scott R., Briones, Sergio, Horger, Brian, Richardson, Carrie L., Jaw-Tsai, Sarah, Hegde, Sharath S.

“…Muscarinic receptor antagonists form the mainstay of the therapeutic options for airway, bladder, and gastrointestinal smooth muscle disorders. Both M 2 and M…”
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S1672 TD-8954 Is a Highly Potent and Selective 5-HT 4 Receptor Agonist with Potential Utility in Disorders of Reduced Gastrointestinal Motility by Beattie, David T., Vickery, Ross G., Armstrong, Scott R., Ropenga, Anna, Cuthbert, Alan W., Humphrey, Patrick P.

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Pharmacological analysis of the interaction of antimuscarinic drugs at M(2) and M(3) muscarinic receptors in vivo using the pithed rat assay by Armstrong, Scott R, Briones, Sergio, Horger, Brian, Richardson, Carrie L, Jaw-Tsai, Sarah, Hegde, Sharath S

“…Muscarinic receptor antagonists form the mainstay of the therapeutic options for airway, bladder, and gastrointestinal smooth muscle disorders. Both M(2) and…”
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A Multivalent Approach to the Design and Discovery of Orally Efficacious 5-HT 4 Receptor Agonists by McKinnell, R. Murray, Armstrong, Scott R., Beattie, David T., Choi, Seok-Ki, Fatheree, Paul R., Gendron, Roland A. L., Goldblum, Adam, Humphrey, Patrick P., Long, Daniel D., Marquess, Daniel G., Shaw, J. P., Smith, Jacqueline A. M., Turner, S. Derek, Vickery, Ross G.

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Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties by McKinnell, R Murray, Armstrong, Scott R, Beattie, David T, Fatheree, Paul R, Long, Daniel D, Marquess, Daniel G, Shaw, Jeng-Pyng, Vickery, Ross G

“…The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the…”
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Measurement of 5-HT sub(4) receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat by Armstrong, Scott R, McCullough, Julia L, Beattie, David T

“…Introduction In vitro studies have demonstrated a 5-HT sub(4) receptor- mediated relaxation of the pre-contracted rat esophagus. However, it is unclear whether…”
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Measurement of 5-HT 4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat by Armstrong, Scott R., McCullough, Julia L., Beattie, David T.

“…In vitro studies have demonstrated a 5-HT 4 receptor-mediated relaxation of the pre-contracted rat esophagus. However, it is unclear whether 5-HT 4 receptor…”
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Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation by Long, Daniel D, Armstrong, Scott R, Beattie, David T, Choi, Seok-Ki, Fatheree, Paul R, Gendron, Roland A L, Genov, Daniel, Goldblum, Adam A, Humphrey, Patrick P, Jiang, Lan, Marquess, Daniel G, Shaw, Jeng-Pyng, Smith, Jacqueline A M, Turner, S Derek, Vickery, Ross G

“…Utilization of Theravance's multivalent approach to drug discovery towards 5-HT(4) receptor agonists with a focus on identification of neutral (non-charged at…”
Get full text