Search Results - "Armstrong, Loren L"

Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association Studies by HAYES, M. Geoffrey, URBANEK, Margrit, MCHUGH, Caitlin P, ACKERMAN, Christine M, BOUCHARD, Luigi, BRISSON, Diane, LAYDEN, Brian T, MIREL, Daniel, DOHENY, Kimberly F, LEYA, Marysa V, LOWN-HECHT, Rachel N, DYER, Alan R, HIVERT, Marie-France, METZGER, Boyd E, REDDY, Timothy E, COX, Nancy J, LOWE, William L, ARMSTRONG, Loren L, MORRISON, Jean, CONG GUO, LOWE, Lynn P, SCHEFTNER, Douglas A, PLUZHNIKOV, Anna, LEVINE, David M

“…Maternal metabolism during pregnancy impacts the developing fetus, affecting offspring birth weight and adiposity. This has important implications for…”
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Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans by Jeff, Janina M, Armstrong, Loren L, Ritchie, Marylyn D, Denny, Joshua C, Kho, Abel N, Basford, Melissa A, Wolf, Wendy A, Pacheco, Jennifer A, Li, Rongling, Chisholm, Rex L, Roden, Dan M, Hayes, M Geoffrey, Crawford, Dana C

“…Type 2 diabetes (T2D) is a complex metabolic disease that disproportionately affects African Americans. Genome-wide association studies (GWAS) have identified…”
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Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study by Kho, Abel N, Hayes, M Geoffrey, Rasmussen-Torvik, Laura, Pacheco, Jennifer A, Thompson, William K, Armstrong, Loren L, Denny, Joshua C, Peissig, Peggy L, Miller, Aaron W, Wei, Wei-Qi, Bielinski, Suzette J, Chute, Christopher G, Leibson, Cynthia L, Jarvik, Gail P, Crosslin, David R, Carlson, Christopher S, Newton, Katherine M, Wolf, Wendy A, Chisholm, Rex L, Lowe, William L

“…Genome-wide association studies (GWAS) require high specificity and large numbers of subjects to identify genotype-phenotype correlations accurately. The aim…”
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Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes by Ng, Maggie C Y, Shriner, Daniel, Chen, Brian H, Li, Jiang, Chen, Wei-Min, Guo, Xiuqing, Liu, Jiankang, Bielinski, Suzette J, Yanek, Lisa R, Nalls, Michael A, Comeau, Mary E, Rasmussen-Torvik, Laura J, Jensen, Richard A, Evans, Daniel S, Sun, Yan V, An, Ping, Patel, Sanjay R, Lu, Yingchang, Long, Jirong, Armstrong, Loren L, Wagenknecht, Lynne, Yang, Lingyao, Snively, Beverly M, Palmer, Nicholette D, Mudgal, Poorva, Langefeld, Carl D, Keene, Keith L, Freedman, Barry I, Mychaleckyj, Josyf C, Nayak, Uma, Raffel, Leslie J, Goodarzi, Mark O, Chen, Y-D Ida, Taylor, Jr, Herman A, Correa, Adolfo, Sims, Mario, Couper, David, Pankow, James S, Boerwinkle, Eric, Adeyemo, Adebowale, Doumatey, Ayo, Chen, Guanjie, Mathias, Rasika A, Vaidya, Dhananjay, Singleton, Andrew B, Zonderman, Alan B, Igo, Jr, Robert P, Sedor, John R, Kabagambe, Edmond K, Siscovick, David S, McKnight, Barbara, Rice, Kenneth, Liu, Yongmei, Hsueh, Wen-Chi, Zhao, Wei, Bielak, Lawrence F, Kraja, Aldi, Province, Michael A, Bottinger, Erwin P, Gottesman, Omri, Cai, Qiuyin, Zheng, Wei, Blot, William J, Lowe, William L, Pacheco, Jennifer A, Crawford, Dana C, Grundberg, Elin, Rich, Stephen S, Hayes, M Geoffrey, Shu, Xiao-Ou, Loos, Ruth J F, Borecki, Ingrid B, Peyser, Patricia A, Cummings, Steven R, Psaty, Bruce M, Fornage, Myriam, Iyengar, Sudha K, Evans, Michele K, Becker, Diane M, Kao, W H Linda, Wilson, James G, Rotter, Jerome I, Sale, Michèle M, Liu, Simin, Rotimi, Charles N, Bowden, Donald W

“…Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite…”
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Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1 by Guo, Cong, Ludvik, Anton E., Arlotto, Michelle E., Hayes, M. Geoffrey, Armstrong, Loren L., Scholtens, Denise M., Brown, Christopher D., Newgard, Christopher B., Becker, Thomas C., Layden, Brian T., Lowe, William L., Reddy, Timothy E.

“…Maternal glucose levels during pregnancy impact the developing fetus, affecting metabolic health both early and later on in life. Both genetic and…”
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Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin by Liu, Ching-Ti, Raghavan, Sridharan, Maruthur, Nisa, Kabagambe, Edmond Kato, Hong, Jaeyoung, Hivert, Marie-France, Lu, Yingchang, Bentley, Amy R., Drolet, Anne M., Gaulton, Kyle J., Guo, Xiuqing, Armstrong, Loren L., Irvin, Marguerite R., Li, Man, Rybin, Denis V., Agyemang, Charles, Palmer, Nicholette D., Cade, Brian E., Chen, Wei-Min, Dauriz, Marco, Delaney, Joseph A.C., Edwards, Todd L., Lange, Leslie A., Leong, Aaron, Liu, Jingmin, Liu, Yongmei, Nayak, Uma, Patel, Sanjay R., Rasmussen-Torvik, Laura J., Snijder, Marieke B., Stallings, Sarah C., Tanaka, Toshiko, Yanek, Lisa R., Becker, Diane M., Bielak, Lawrence F., Biggs, Mary L., Chen, Guanjie, Correa, Adolfo, Couper, David J., Crawford, Dana C., Cushman, Mary, Eicher, John D., Fornage, Myriam, Franceschini, Nora, Fu, Yi-Ping, Goodarzi, Mark O., Gottesman, Omri, Harris, Tamara B., Jensen, Richard A., Jhun, Min A., Karter, Andrew J., Keller, Margaux F., Kho, Abel N., Kizer, Jorge R., Krauss, Ronald M., Langefeld, Carl D., Li, Xiaohui, Liang, Jingling, Liu, Simin, Lowe, William L., Mosley, Thomas H., North, Kari E., Pacheco, Jennifer A., Peyser, Patricia A., Patrick, Alan L., Rice, Kenneth M., Selvin, Elizabeth, Sims, Mario, Tajuddin, Salman M., Vaidya, Dhananjay, Wren, Mary P., Yao, Jie, Ziegler, Julie T., Zmuda, Joseph M., Zonderman, Alan B., Zwinderman, Aeilko H., Adeyemo, Adebowale, Boerwinkle, Eric, Ferrucci, Luigi, Hayes, M. Geoffrey, Kardia, Sharon L.R., Miljkovic, Iva, Pankow, James S., Rotimi, Charles N., Sale, Michele M., Wagenknecht, Lynne E., Arnett, Donna K., Chen, Yii-Der Ida, Province, Michael A., Kao, W.H. Linda, Siscovick, David S., Psaty, Bruce M., Wilson, James G., Loos, Ruth J.F., Dupuis, Josée, Rich, Stephen S., Florez, Jose C., Rotter, Jerome I., Morris, Andrew P., Meigs, James B.

“…Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting glucose (FG) and insulin (FI) in African ancestry (AA)…”
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A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis by Marangoni, Roberta Goncalves, Korman, Benjamin D, Allanore, Yannick, Dieude, Philippe, Armstrong, Loren L, Rzhetskaya, Margarita, Hinchcliff, Monique, Carns, Mary, Podlusky, Sofia, Shah, Sanjiv J, Ruiz, Barbara, Hachulla, Eric, Tiev, Kiet, Cracowski, Jean-Luc, Varga, John, Hayes, M Geoffrey

“…The multifunctional nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has potent anti-fibrotic effects, and its expression and…”
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Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations by Hayes, M Geoffrey, Urbanek, Margrit, Ehrmann, David A, Armstrong, Loren L, Lee, Ji Young, Sisk, Ryan, Karaderi, Tugce, Barber, Thomas M, McCarthy, Mark I, Franks, Stephen, Lindgren, Cecilia M, Welt, Corrine K, Diamanti-Kandarakis, Evanthia, Panidis, Dimitrios, Goodarzi, Mark O, Azziz, Ricardo, Zhang, Yi, James, Roland G, Olivier, Michael, Kissebah, Ahmed H, Stener-Victorin, Elisabet, Legro, Richard S, Dunaif, Andrea

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Quality control procedures for genome-wide association studies by Turner, Stephen, Armstrong, Loren L, Bradford, Yuki, Carlson, Christopher S, Crawford, Dana C, Crenshaw, Andrew T, de Andrade, Mariza, Doheny, Kimberly F, Haines, Jonathan L, Hayes, Geoffrey, Jarvik, Gail, Jiang, Lan, Kullo, Iftikhar J, Li, Rongling, Ling, Hua, Manolio, Teri A, Matsumoto, Martha, McCarty, Catherine A, McDavid, Andrew N, Mirel, Daniel B, Paschall, Justin E, Pugh, Elizabeth W, Rasmussen, Luke V, Wilke, Russell A, Zuvich, Rebecca L, Ritchie, Marylyn D

“…Genome-wide association studies (GWAS) are being conducted at an unprecedented rate in population-based cohorts and have increased our understanding of the…”
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Genetic Risk Score for Prediction of Newborn Adiposity and Large-for-Gestational-Age Birth by Chawla, Reeti, Badon, Sylvia E, Rangarajan, Janani, Reisetter, Anna C, Armstrong, Loren L, Lowe, Lynn P, Urbanek, Margrit, Metzger, Boyd E, Hayes, M. Geoffrey, Scholtens, Denise M, Lowe, William L

“…Context: Macrosomic infants are at increased risk for adverse metabolic outcomes. Improving prediction of large-for-gestational-age (LGA) birth may help…”
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The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study by Urbanek, Margrit, Hayes, M Geoffrey, Armstrong, Loren L, Morrison, Jean, Lowe, Lynn P, Badon, Sylvia E, Scheftner, Doug, Pluzhnikov, Anna, Levine, David, Laurie, Cathy C, McHugh, Caitlin, Ackerman, Christine M, Mirel, Daniel B, Doheny, Kimberly F, Guo, Cong, Scholtens, Denise M, Dyer, Alan R, Metzger, Boyd E, Reddy, Timothy E, Cox, Nancy J, Lowe, Jr, William L

“…Newborns characterized as large and small for gestational age are at risk for increased mortality and morbidity during the first year of life as well as for…”
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Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations by Hayes, M. Geoffrey, Urbanek, Margrit, Ehrmann, David A., Armstrong, Loren L., Lee, Ji Young, Sisk, Ryan, Karaderi, Tugce, Barber, Thomas M., McCarthy, Mark I., Franks, Stephen, Lindgren, Cecilia M., Welt, Corrine K., Diamanti-Kandarakis, Evanthia, Panidis, Dimitrios, Goodarzi, Mark O., Azziz, Ricardo, Zhang, Yi, James, Roland G., Olivier, Michael, Kissebah, Ahmed H., Stener-Victorin, Elisabet, Legro, Richard S., Dunaif, Andrea

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality by Zuvich, Rebecca L., Armstrong, Loren L., Bielinski, Suzette J., Bradford, Yuki, Carlson, Christopher S., Crawford, Dana C., Crenshaw, Andrew T., de Andrade, Mariza, Doheny, Kimberly F., Haines, Jonathan L., Hayes, M. Geoffrey, Jarvik, Gail P., Jiang, Lan, Kullo, Iftikhar J., Li, Rongling, Ling, Hua, Manolio, Teri A., Matsumoto, Martha E., McCarty, Catherine A., McDavid, Andrew N., Mirel, Daniel B., Olson, Lana M., Paschall, Justin E., Pugh, Elizabeth W., Rasmussen, Luke V., Rasmussen-Torvik, Laura J., Turner, Stephen D., Wilke, Russell A., Ritchie, Marylyn D.

“…Genome‐wide association studies (GWAS) are a useful approach in the study of the genetic components of complex phenotypes. Aside from large cohorts, GWAS have…”
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A Validated Phenotyping Algorithm for Genetic Association Studies in Age-related Macular Degeneration by Simonett, Joseph M., Sohrab, Mahsa A., Pacheco, Jennifer, Armstrong, Loren L., Rzhetskaya, Margarita, Smith, Maureen, Hayes, M. Geoffrey, Fawzi, Amani A.

“…Age-related macular degeneration (AMD), a multifactorial, neurodegenerative disease, is a leading cause of vision loss. With the rapid advancement of DNA…”
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High Density GWAS for LDL Cholesterol in African Americans Using Electronic Medical Records Reveals a Strong Protective Variant in APOE by Rasmussen-Torvik, Laura J., Pacheco, Jennifer A., Wilke, Russell A., Thompson, William K., Ritchie, Marylyn D., Kho, Abel N., Muthalagu, Arun, Hayes, M. Geoff, Armstrong, Loren L., Scheftner, Douglas A., Wilkins, John T., Zuvich, Rebecca L., Crosslin, David, Roden, Dan M., Denny, Joshua C., Jarvik, Gail P., Carlson, Christopher S., Kullo, Iftikhar J., Bielinski, Suzette J., McCarty, Catherine A., Li, Rongling, Manolio, Teri A., Crawford, Dana C., Chisholm, Rex L.

“…Only one low‐density lipoprotein cholesterol (LDL‐C) genome‐wide association study (GWAS) has been previously reported in ‐African Americans. We performed a…”
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Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight by Tyrrell, Jessica, Richmond, Rebecca C, Palmer, Tom M, Feenstra, Bjarke, Rangarajan, Janani, Metrustry, Sarah, Cavadino, Alana, Paternoster, Lavinia, Armstrong, Loren L, De Silva, N. Maneka G, Wood, Andrew R, Horikoshi, Momoko, Geller, Frank, Myhre, Ronny, Bradfield, Jonathan P, Kreiner-Møller, Eskil, Huikari, Ville, Painter, Jodie N, Hottenga, Jouke-Jan, Allard, Catherine, Berry, Diane J, Bouchard, Luigi, Das, Shikta, Evans, David M, Hakonarson, Hakon, Hayes, M. Geoffrey, Heikkinen, Jani, Hofman, Albert, Knight, Bridget, Lind, Penelope A, McCarthy, Mark I, McMahon, George, Medland, Sarah E, Melbye, Mads, Morris, Andrew P, Nodzenski, Michael, Reichetzeder, Christoph, Ring, Susan M, Sebert, Sylvain, Sengpiel, Verena, Sørensen, Thorkild I. A, Willemsen, Gonneke, de Geus, Eco J. C, Martin, Nicholas G, Spector, Tim D, Power, Christine, Järvelin, Marjo-Riitta, Bisgaard, Hans, Grant, Struan F. A, Nohr, Ellen A, Jaddoe, Vincent W, Jacobsson, Bo, Murray, Jeffrey C, Hocher, Berthold, Hattersley, Andrew T, Scholtens, Denise M, Davey Smith, George, Hivert, Marie-France, Felix, Janine F, Hyppönen, Elina, Lowe, William L, Frayling, Timothy M, Lawlor, Debbie A, Freathy, Rachel M

“…IMPORTANCE: Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are…”
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Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations by Hayes, M. Geoffrey, Urbanek, Margrit, Ehrmann, David A., Armstrong, Loren L., Lee, Ji Young, Sisk, Ryan, Karaderi, Tugce, Barber, Thomas M., McCarthy, Mark I., Franks, Stephen, Lindgren, Cecilia M., Welt, Corrine K., Diamanti-Kandarakis, Evanthia, Panidis, Dimitrios, Goodarzi, Mark O., Azziz, Ricardo, Zhang, Yi, James, Roland G., Olivier, Michael, Kissebah, Ahmed H., Stener-Victorin, Elisabet, Legro, Richard S., Dunaif, Andrea

“…Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and…”
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A novel common variant in DCST2 is associated with length in early life and height in adulthood by van der Valk, Ralf J P, Kreiner-Møller, Eskil, Kooijman, Marjolein N, Guxens, Mònica, Stergiakouli, Evangelia, Sääf, Annika, Bradfield, Jonathan P, Geller, Frank, Hayes, M Geoffrey, Cousminer, Diana L, Körner, Antje, Thiering, Elisabeth, Curtin, John A, Myhre, Ronny, Huikari, Ville, Joro, Raimo, Kerkhof, Marjan, Warrington, Nicole M, Pitkänen, Niina, Ntalla, Ioanna, Horikoshi, Momoko, Veijola, Riitta, Freathy, Rachel M, Teo, Yik-Ying, Barton, Sheila J, Evans, David M, Kemp, John P, St Pourcain, Beate, Ring, Susan M, Davey Smith, George, Bergström, Anna, Kull, Inger, Hakonarson, Hakon, Mentch, Frank D, Bisgaard, Hans, Chawes, Bo, Stokholm, Jakob, Waage, Johannes, Eriksen, Patrick, Sevelsted, Astrid, Melbye, Mads, van Duijn, Cornelia M, Medina-Gomez, Carolina, Hofman, Albert, de Jongste, Johan C, Taal, H Rob, Uitterlinden, André G, Armstrong, Loren L, Eriksson, Johan, Palotie, Aarno, Bustamante, Mariona, Estivill, Xavier, Gonzalez, Juan R, Llop, Sabrina, Kiess, Wieland, Mahajan, Anubha, Flexeder, Claudia, Tiesler, Carla M T, Murray, Clare S, Simpson, Angela, Magnus, Per, Sengpiel, Verena, Hartikainen, Anna-Liisa, Keinanen-Kiukaanniemi, Sirkka, Lewin, Alexandra, Da Silva Couto Alves, Alexessander, Blakemore, Alexandra I, Buxton, Jessica L, Kaakinen, Marika, Rodriguez, Alina, Sebert, Sylvain, Vaarasmaki, Marja, Lakka, Timo, Lindi, Virpi, Gehring, Ulrike, Postma, Dirkje S, Ang, Wei, Newnham, John P, Lyytikäinen, Leo-Pekka, Pahkala, Katja, Raitakari, Olli T, Panoutsopoulou, Kalliope, Zeggini, Eleftheria, Boomsma, Dorret I, Groen-Blokhuis, Maria, Ilonen, Jorma, Franke, Lude, Hirschhorn, Joel N, Pers, Tune H, Liang, Liming, Huang, Jinyan, Hocher, Berthold, Knip, Mikael, Saw, Seang-Mei, Holloway, John W, Melén, Erik, Grant, Struan F A, Feenstra, Bjarke, Lowe, William L, Widén, Elisabeth

“…Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common…”
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A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women by Haddad, Stephen A, Palmer, Julie R, Lunetta, Kathryn L, Ng, Maggie C Y, Ruiz-Narváez, Edward A

“…SNP rs7903146 in the Wnt pathway's TCF7L2 gene is the variant most significantly associated with type 2 diabetes to date, with associations observed across…”
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Correction: Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations by Hayes, M. Geoffrey, Urbanek, Margrit, Ehrmann, David A., Armstrong, Loren L., Lee, Ji Young, Sisk, Ryan, Karaderi, Tugce, Barber, Thomas M., McCarthy, Mark I., Franks, Stephen, Lindgren, Cecilia M., Welt, Corrine K., Diamanti-Kandarakis, Evanthia, Panidis, Dimitrios, Goodarzi, Mark O., Azziz, Ricardo, Zhang, Yi, James, Roland G., Olivier, Michael, Kissebah, Ahmed H., Stener-Victorin, Elisabet, Legro, Richard S., Dunaif, Andrea

“…Nature Communications 6: Article number: 7502 (2015); Published: 18 August 2015; Updated: 12 February 2016 In the original version of this Article the genetic…”
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