Search Results - "Armour, D R"

GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity by Gardner, C J, Armour, D R, Beattie, D T, Gale, J D, Hawcock, A B, Kilpatrick, G J, Twissell, D J, Ward, P

“…It has been demonstrated recently that antagonists of the tachykinin NK1 receptor, specifically CP-99,994 and GR203040, possess anti-emetic activity in a range…”
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Discovery of an Orally Bioavailable NK1 Receptor Antagonist, (2S,3S)-(2-Methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with Potent Antiemetic Activity by Ward, Peter, Armour, Duncan R, Bays, David E, Evans, Brian, Giblin, Gerard M. P, Heron, Nicola, Hubbard, Tania, Liang, Kai, Middlemiss, David

“…The antiemetic, pharmacokinetic, and metabolic profile of CP-99,994, a potent NK1 receptor antagonist, has been carefully evaluated. As a result we began a…”
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1,4-Benzodiazepin-2-one derived neurokinin-1 receptor antagonists by Armour, D.R., Aston, N.M., Morriss, K.M.L., Congreve, M.S., Hawcock, A.B., Marquess, D., Mordaunt, J.E., Richards, S.A., Ward, P.

“…The identification of a series of 1,4-benzodiazepin-2-one derived NK 1 receptor antagonists is described and a bioactive conformation is proposed. A new class…”
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Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger” by Aquino, Christopher J, Armour, Duncan R, Berman, Judd M, Birkemo, Larry S, Carr, Robin A. E, Croom, Dallas K, Dezube, Milana, Dougherty, Robert W, Ervin, Gregory N, Grizzle, Mary K, Head, Julie E, Hirst, Gavin C, James, Michael K, Johnson, Michael F, Miller, Laurence J, Queen, Kennedy L, Rimele, Thomas J, Smith, David N, Sugg, Elizabeth E

“…Directed screening of compounds selected from the Glaxo registry file for contractile activity on the isolated guinea pig gallbladder (GPGB) identified a…”
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Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound by Armour, D.R., Chung, K.M.L., Congreve, M., Evans, B., Guntrip, S., Hubbard, T., Kay, C., Middlemiss, D., Mordaunt, J.E., Pegg, N.A., Vinader, M.V., Ward, P., Watson, S.P.

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Team training can improve operating room performance by Forse, R. Armour, MD, PhD, FACS, Bramble, J.D., PhD, McQuillan, Robert, MD

“…Background This study was conducted to determine if team training using a federally sponsored team training program improves operating room (OR) performance…”
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Development and Validation of a Risk Calculator Predicting Postoperative Respiratory Failure by Gupta, Himani, MD, Gupta, Prateek K., MD, Fang, Xiang, PhD, Miller, Weldon J., MS, Cemaj, Samuel, MD, Forse, R. Armour, MD, PhD, Morrow, Lee E., MD, FCCP

“…Background Postoperative respiratory failure (PRF) (requiring mechanical ventilation > 48 h after surgery or unplanned intubation within 30 days of surgery) is…”
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Development and Validation of a Bariatric Surgery Morbidity Risk Calculator Using the Prospective, Multicenter NSQIP Dataset by Gupta, Prateek K., MD, Franck, Christopher, PhD, Miller, Weldon J., MS, Gupta, Himani, MD, Forse, R. Armour, MD, PhD, FACS

“…Background Although a risk score estimating postoperative mortality for patients undergoing gastric bypass exists, there is none predicting postoperative…”
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Development and Validation of a Bariatric Surgery Mortality Risk Calculator by Ramanan, Bala, MBBS, Gupta, Prateek K., MD, Gupta, Himani, MD, Fang, Xiang, PhD, Forse, R. Armour, MD, PhD, FACS

“…Background While the epidemic of obesity continues to plague America, bariatric surgery is underused due to concerns for surgical risk among patients and…”
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Enantioselective Synthesis of 3,6-Dihydro-1H-pyridin-2-ones:  Unexpected Regioselectivity in the Palladium-Catalyzed Decarboxylative Carbonylation of 5-Vinyloxazolidin-2-ones by Knight, Julian G, Ainge, Simon W, Harm, Andrew M, Harwood, Simon J, Maughan, Haydn I, Armour, Duncan R, Hollinshead, David M, Jaxa-Chamiec, Albert A

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The Discovery of Tropane-derived CCR5 Receptor Antagonists by Armour, Duncan R., De Groot, Marcel J., Price, David A., Stammen, Blanda L. C., Wood, Anthony, Perros, Manos, Burt, Catherine

“…The development of compound 1, a piperidine‐based CCR5 receptor antagonist with Type I CYP2D6 inhibition, into the tropane‐derived analogue 5, is described…”
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Spiro-piperidine non-peptide neurokinin-1 receptor antagonists by Armour, D.R., Watson, S.P., Pegg, N.A., Heron, N.M., Middlemiss, D., Chan, C., Cholerton, T.J., Hubbard, T., Vinader, M.V., Davies, H.G., Cocker, J.D., Bays, D.E., Ward, P.

“…The synthesis and activity of a novel spiro-piperidine non-peptide antagonist (2) of the neurokinin-1 (NK 1) receptor is described. Despite having essentially…”
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GR205171 : A novel antagonist with high affinity for the trachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity by GARDNER, C. J, ARMOUR, D. R, BEATTIE, D. T, GALE, J. D, HAWCOCK, A. B, KILPATRICK, G. J, TWISSELL, D. J, WARD, P

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Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. I: Optimization of the agonist trigger by AQUINO, C. J, ARMOUR, D. R, HEAD, J. E, HIRST, G. C, JAMES, M. K, JOHNSON, M. F, MILLER, L. J, QUEEN, K. L, RIMELE, T. J, SMITH, D. N, SUGG, E. E, BERMAN, J. M, BIRKEMA, L. S, CARR, R. A. E, CROOM, D. K, DEZUBE, M, DOUGHERTY, R. W, ERVIN, G. N, GRIZZLE, M. K

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