The Persistence of Antigen in the Mouse
The persistence of a single intravenous injection of TMV in the mouse has been investigated by two independent methods which are free of many ambiguities. P32 labeled TMV has been isolated from liver extracts 9 days after intravenous injection by means of specific precipitation with rabbit antiserum...
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| Published in: | The Journal of immunology (1950) Vol. 71; no. 1; pp. 30 - 37 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Am Assoc Immnol
01-07-1953
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The persistence of a single intravenous injection of TMV in the mouse has been investigated by two independent methods which are free of many ambiguities.
P32 labeled TMV has been isolated from liver extracts 9 days after intravenous injection by means of specific precipitation with rabbit antiserum to TMV.
Direct observation of liver extracts in the electron microscope has revealed the presence of particles strikingly similar in size and shape to TMV through 15 days after intravenous injection.
It is evident that the mouse cannot rapidly dispose of a 2 mg intravenous dose of TMV.
These results suggest that the presence of antigen is a prerequisite for antibody formation. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0022-1767 1550-6606 |
| DOI: | 10.4049/jimmunol.71.1.30 |