Search Results - "Armbrust, Tammy"
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Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages
Published in mBio (26-10-2021)“…The coronavirus disease 2019 (COVID-19) pandemic has raised concerns about the detrimental effects of antibodies. Antibody-dependent enhancement (ADE) of…”
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The landscape of antibody binding in SARS-CoV-2 infection
Published in PLoS biology (18-06-2021)“…The search for potential antibody-based diagnostics, vaccines, and therapeutics for pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has…”
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Protective Immunity and Persistent Lung Sequelae in Domestic Cats after SARS-CoV-2 Infection
Published in Emerging infectious diseases (01-02-2021)“…Severe acute respiratory syndrome coronavirus 2 readily transmits between domestic cats. We found that domestic cats that recover from an initial infection…”
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Efficacy of vaccination and previous infection against the Omicron BA.1 variant in Syrian hamsters
Published in Cell reports (Cambridge) (19-04-2022)“…The emergence of the SARS-CoV-2 Omicron (B.1.1.529) variant with a surprising number of spike mutations raises concerns about reduced sensitivity of this virus…”
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Long-term, infection-acquired immunity against the SARS-CoV-2 Delta variant in a hamster model
Published in Cell reports (Cambridge) (15-02-2022)“…The emergence of the SARS-CoV-2 Delta variant (B.1.617.2) raises concerns about potential reduced sensitivity of the virus to antibody neutralization and…”
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Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression
Published in Journal of virology (15-02-2016)“…Marburg virus (MARV), a member of the filovirus family, causes severe hemorrhagic fever with up to 90% lethality. MARV matrix protein VP40 is essential for…”
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Co-administration of Favipiravir and the Remdesivir Metabolite GS-441524 Effectively Reduces SARS-CoV-2 Replication in the Lungs of the Syrian Hamster Model
Published in mBio (01-02-2022)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide since December 2019, causing coronavirus disease 2019 (COVID-19). Although…”
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Serological analysis of Ebola virus survivors and close contacts in Sierra Leone: A cross-sectional study
Published in PLoS neglected tropical diseases (01-08-2019)“…The 2013-2016 Ebola virus outbreak in West Africa was the largest and deadliest outbreak to date. Here we conducted a serological study to examine the antibody…”
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Characterization of Omicron BA.4.6, XBB, and BQ.1.1 subvariants in hamsters
Published in Communications biology (15-03-2024)“…During the Omicron wave, previous variants such as BA.2, BA.4, and BA.5 were replaced by newer variants with additional mutations in the spike protein. These…”
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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development
Published in Proceedings of the National Academy of Sciences - PNAS (14-07-2020)“…At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around…”
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Recombinant spike protein vaccines coupled with adjuvants that have different modes of action induce protective immunity against SARS-CoV-2
Published in Vaccine (22-09-2023)“…The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a glycoprotein, expressed on the virion surface, that mediates…”
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Characterization of the SARS-CoV-2 B.1.621 (Mu) variant
Published in Science translational medicine (10-08-2022)“…The SARS-CoV-2 B.1.621 (Mu) variant emerged in January 2021 and was categorized as a variant of interest by the World Health Organization in August 2021. This…”
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Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronaviruses
Published in EBioMedicine (01-12-2022)“…The COVID-19 pandemic continues to cause morbidity and mortality worldwide. Most approved COVID-19 vaccines generate a neutralizing antibody response that…”
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Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responsesResearch in context
Published in EBioMedicine (01-05-2024)“…Background: World Health Organisation (WHO) and USA Centers for Disease Control and Prevention (U.S. CDC) recommendations now allow simultaneous administration…”
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Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responses
Published in EBioMedicine (01-05-2024)“…World Health Organisation (WHO) and USA Centers for Disease Control and Prevention (U.S. CDC) recommendations now allow simultaneous administration of COVID-19…”
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Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronavirusesResearch in context
Published in EBioMedicine (01-12-2022)“…Background: The COVID-19 pandemic continues to cause morbidity and mortality worldwide. Most approved COVID-19 vaccines generate a neutralizing antibody…”
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Specific COVID-19 Symptoms Correlate with High Antibody Levels against SARS-CoV-2
Published in ImmunoHorizons (17-06-2021)“…Lasting immunity will be critical for overcoming COVID-19. However, the factors associated with the development of high titers of anti-SARS-CoV-2 Abs and how…”
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