Search Results - "Arman, Tarana"

Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans by Arman, Tarana, Clarke, John D

“…Microcystins are ubiquitous toxins produced by photoautotrophic cyanobacteria. Human exposures to microcystins occur through the consumption of contaminated…”
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Endocrine and paracrine characteristics of neuroendocrine prostate cancer by Arman, Tarana, Nelson, Peter S

“…Prostate cancer is a common malignancy affecting men worldwide. While the vast majority of newly diagnosed prostate cancers are categorized as adenocarcinomas,…”
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Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin‐drug interactions by Lynch, Katherine D., Montonye, Michelle L., Tian, Dan‐Dan, Arman, Tarana, Oyanna, Victoria O., Bechtold, Baron J., Graf, Tyler N., Oberlies, Nicholas H., Paine, Mary F., Clarke, John D.

“…Silybum marianum (L.) Gaertn. (Asteraceae), commonly known as milk thistle, is a botanical natural product used to self‐treat multiple diseases such as Type 2…”
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Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats by Arman, Tarana, Lynch, Katherine D, Montonye, Michelle L, Goedken, Michael, Clarke, John D

“…Microcystin-LR (MCLR) is a hepatotoxic cyanotoxin reported to cause a phenotype similar to nonalcoholic steatohepatitis (NASH). NASH is a common progressive…”
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A Pharmacokinetic natural product-disease-drug interaction: a double-hit on hepatic transporters by Clarke, John, Arman, Tarana, Paine, Mary, Gastecki, Michelle

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Sub-chronic microcystin-LR renal toxicity in rats fed a high fat/high cholesterol diet by Arman, Tarana, Lynch, Katherine D., Goedken, Michael, Clarke, John D.

“…Microcystin-LR (MCLR) is a liver and kidney toxin produced by cyanobacteria. Recently, it was demonstrated that MCLR exposure drives the progression of high…”
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Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans by Koritala, Bala S. C., Porter, Kenneth I., Arshad, Osama A., Gajula, Rajendra P., Mitchell, Hugh D., Arman, Tarana, Manjanatha, Mugimane G., Teeguarden, Justin, Van Dongen, Hans P. A., McDermott, Jason E., Gaddameedhi, Shobhan

“…Circadian disruption has been identified as a risk factor for health disorders such as obesity, cardiovascular disease, and cancer. Although epidemiological…”
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MCLR-elicited hepatic fibrosis and carcinogenic gene expression changes persist in rats with diet-induced nonalcoholic steatohepatitis through a 4-week recovery period by Arman, Tarana, Baron, J. Allen, Lynch, Katherine D., White, Laura A., Aldan, Johnny, Clarke, John D.

“…•Recovery from MCLR toxicity did not resolve burnt-out NASH phenotype in NASH.•MCLR-elicited fibrosis persisted through 4 weeks of recovery in NASH.•MCLR…”
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Microcystin-LR Hepatic and Renal Toxicity in Nonalcoholic Fatty Liver Disease by Arman, Tarana

“…Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. Up to 54% of patients with a severe form of NAFLD,…”
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0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule by Van Dongen, Hans, Koritala, Bala, Porter, Kenneth, Arshad, Osama, Gajula, Rajendra, Mitchell, Hugh, Arman, Tarana, Manjanatha, Mugimane, Teeguarden, Justin, McDermott, Jason, Gaddameedhi, Shobhan

“…Abstract Introduction Circadian misalignment from night shift (NS) work is associated with increased risk of cancer. In a simulated NS study, we sought to…”
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Differential Effects of Silymarin on Pitavastatin Disposition in Rodent Models of Simple Fatty Liver versus Nonalcoholic Steatohepatitis: A Natural Product‐Disease‐Drug Interaction by Tian, Dan‐dan, Gastecki, Michelle, Lynch, Katherine D, Arman, Tarana, Paine, Mary F, Clarke, John

“…Nonalcoholic fatty liver disease (NAFLD) progresses from simple fatty liver (SFL) to nonalcoholic steatohepatitis (NASH). This progression alters hepatic…”
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Abstract C033: Identifying and targeting prostate cancer therapy resistance mechanisms driven by the tumor microenvironment by Heng Chu, Tony Lok, Bankhead, Armand, Coleman, Ilsa, Frank, Sander, Nelson, Peter S., Arman, Tarana

“…Abstract Background: Prostate cancer is a prevalent malignancy in men, with treatment resistance posing a significant challenge to successful cure. Acquired…”
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A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model by Montonye, Michelle L, Tian, Dan-Dan, Arman, Tarana, Lynch, Katherine D, Hagenbuch, Bruno, Paine, Mary F, Clarke, John D

“…Patients with nonalcoholic steatohepatitis (NASH) exhibit altered hepatic protein expression of metabolizing enzymes and transporters and altered xenobiotic…”
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Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity by Clarke, John D., Dzierlenga, Anika, Arman, Tarana, Toth, Erica, Li, Hui, Lynch, Katherine D., Tian, Dan-Dan, Goedken, Michael, Paine, Mary F., Cherrington, Nathan

“…Microcystin-LR (MCLR) is a cyanotoxin produced by blue-green algae that causes liver and kidney toxicities. MCLR toxicity is dependent on cellular uptake…”
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