Search Results - "Armakola, Maria"

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models by Armakola, Maria, Higgins, Matthew J, Figley, Matthew D, Barmada, Sami J, Scarborough, Emily A, Diaz, Zamia, Fang, Xiaodong, Shorter, James, Krogan, Nevan J, Finkbeiner, Steven, Farese, Robert V, Gitler, Aaron D

“…Aaron Gitler, Robert Farese Jr. and colleagues identify the RNA lariat debranching enzyme Dbr1 as a potent suppressor of TDP-43 toxicity in yeast. They further…”
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Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans by Garcia, Susana M D A, Tabach, Yuval, Lourenço, Guinevere F, Armakola, Maria, Ruvkun, Gary

“…A screen identifies 15 genes that modulate CUG-repeat toxicity in C. elegans , including those encoding RNA-export and clearance factors. Toxic RNAs are…”
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Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes by Armakola, Maria, Ruvkun, Gary

“…Many neurons display characteristic patterns of synaptic connections that are under genetic control. The Caenorhabditis elegans DA cholinergic motor neurons…”
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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS by Elden, Andrew C., Kim, Hyung-Jun, Hart, Michael P., Chen-Plotkin, Alice S., Johnson, Brian S., Fang, Xiaodong, Armakola, Maria, Geser, Felix, Greene, Robert, Lu, Min Min, Padmanabhan, Arun, Clay-Falcone, Dana, McCluskey, Leo, Elman, Lauren, Juhr, Denise, Gruber, Peter J., Rüb, Udo, Auburger, Georg, Trojanowski, John Q., Lee, Virginia M.-Y., Van Deerlin, Vivianna M., Bonini, Nancy M., Gitler, Aaron D.

“…The causes of amyotrophic lateral sclerosis (ALS), a devastating human neurodegenerative disease, are poorly understood, although the protein TDP-43 has been…”
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Cellular Oligomerization of α-Synuclein Is Determined by the Interaction of Oxidized Catechols with a C-terminal Sequence by Mazzulli, Joseph R., Armakola, Maria, Dumoulin, Michelle, Parastatidis, Ioannis, Ischiropoulos, Harry

“…The mechanisms that govern the formation of α-synuclein (α-syn) aggregates are not well understood but are considered a central event in the pathogenesis of…”
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TDP-43 toxicity in yeast by Armakola, Maria, Hart, Michael P., Gitler, Aaron D.

“…The budding yeast Saccharomyces cerevisiae is an emerging tool for investigating the molecular pathways that underpin several human neurodegenerative disorders…”
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Identification of genes in trinucleotide repeat RNA toxicity pathways in C. elegans by Garcia, Susana M. D. A., Tabach, Yuval, Lourenço, Guinevere F., Armakola, Maria, Ruvkun, Gary

“…Myotonic dystrophy disorders are caused by expanded CUG repeats in non-coding regions. To reveal mechanisms of CUG repeat pathogenesis we used C. elegans…”
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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models by Armakola, Maria

“…Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease that primarily affects upper and lower motor neurons and results in paralysis…”
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Cellular Oligomerization of α-Synuclein Is Determined by the Interaction of Oxidized Catechols with a C-terminal Sequence by Joseph R. Mazzulli, Maria Armakola, Michelle Dumoulin, Ioannis Parastatidis, Harry Ischiropoulos

“…The mechanisms that govern the formation of α-synuclein (α-syn) aggregates are not well understood but are considered a central event in the pathogenesis of…”
Get full text