Search Results - "Arlt, Matthias J.E."

Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment by ARIT, Matthias J. E, NOVAK-HOFER, Ilse, GAST, Daniela, GSCHWEND, Verena, MOLDENHAUER, Gerhard, GRÜNBERG, Jurgen, HONER, Michael, SCHUBIGER, P. August, ALTEVOGT, Peter, KRUGER, Achim

“…The L1 cell adhesion molecule is implicated in the control of proliferation, migration, and invasion of several tumor cell types in vitro. Recently, L1…”
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Antimetastatic activity of a novel mechanism-based gelatinase inhibitor by KRÜGER, Achim, ANT, Matthias J. E, GERG, Michael, KOPITZ, Charlotte, MARGARIDA BERNARDO, M, CHANG, Mayland, MOBASHERY, Shahriar, FRIDMAN, Rafael

“…Matrix metalloproteinases (MMPs), and in particular gelatinases (MMP-2 and MMP-9), play a key role in cancer progression. However, clinical trials in which MMP…”
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Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming by Mazumdar, Alekhya, Urdinez, Joaquin, Boro, Aleksandar, Migliavacca, Jessica, Arlt, Matthias J E, Muff, Roman, Fuchs, Bruno, Snedeker, Jess Gerrit, Gvozdenovic, Ana

“…Tumor-secreted extracellular vesicles (EVs) have been identified as mediators of cancer-host intercellular communication and shown to support pre-metastatic…”
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Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model by Mazumdar, Alekhya, Urdinez, Joaquin, Boro, Aleksandar, Arlt, Matthias J. E., Egli, Fabian E., Niederöst, Barbara, Jaeger, Patrick K., Moschini, Greta, Muff, Roman, Fuchs, Bruno, Snedeker, Jess G., Gvozdenovic, Ana

“…The pre-metastatic niche (PMN) is a tumor-driven microenvironment in distant organs that can foster and support the survival and growth of disseminated tumor…”
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Matrix Metalloproteinase 1 promotes tumor formation and lung metastasis in an intratibial injection osteosarcoma mouse model by Husmann, Knut, Arlt, Matthias J E, Muff, Roman, Langsam, Bettina, Bertz, Josefine, Born, Walter, Fuchs, Bruno

“…Proteolytic degradation of the extracellular matrix (ECM) is an important process during tumor invasion. Matrix Metalloproteinase 1 (MMP-1) is one of the…”
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Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice by Sabile, Adam A., Arlt, Matthias J.E., Muff, Roman, Husmann, Knut, Hess, Daniel, Bertz, Josefine, Langsam, Bettina, Aemisegger, Caroline, Ziegler, Urs, Born, Walter, Fuchs, Bruno

“…Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents. More than 30% of patients develop lung metastasis, which is the…”
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LacZ transgene expression in the subcutaneous Dunn/LM8 osteosarcoma mouse model allows for the identification of micrometastasis by Arlt, Matthias J.E., Banke, Ingo J., Walters, Denise K., Puskas, Gabor J., Steinmann, Patrick, Muff, Roman, Born, Walter, Fuchs, Bruno

“…More effective treatment of patients with metastasizing osteosarcoma (OS) with a mean 5‐year survival rate of <20% requires more detailed knowledge on the…”
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The antineoplastic antibiotic taurolidine promotes lung and liver metastasis in two syngeneic osteosarcoma mouse models and exhibits severe liver toxicity by Arlt, Matthias J.E., Walters, Denise K., Banke, Ingo J., Steinmann, Patrick, Puskas, Gabor J., Bertz, Josefine, Rentsch, Katharina M., Ehrensperger, Felix, Born, Walter, Fuchs, Bruno

“…Osteosarcoma (OS) is the most frequent primary bone tumor. Despite multiagent neoadjuvant chemotherapy, patients with metastatic disease have a poor prognosis…”
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Reduced Latency in the Metastatic Niche Contributes to the More Aggressive Phenotype of LM8 Compared to Dunn Osteosarcoma Cells by Arlt, Matthias J. E., Banke, Ingo J., Bertz, Josefine, Ram Kumar, Ram Mohan, Muff, Roman, Born, Walter, Fuchs, Bruno

“…Metastasis is the major cause of death of osteosarcoma patients and its diagnosis remains difficult. In preclinical studies, however, forced expression of…”
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The miR‐143/145 Cluster, a Novel Diagnostic Biomarker in Chondrosarcoma, Acts as a Tumor Suppressor and Directly Inhibits Fascin‐1 by Urdinez, Joaquin, Boro, Aleksandar, Mazumdar, Alekhya, Arlt, Matthias JE, Muff, Roman, Botter, Sander M, Bode‐Lesniewska, Beata, Fuchs, Bruno, Snedeker, Jess G, Gvozdenovic, Ana

“…ABSTRACT Chondrosarcoma is the second most frequent bone sarcoma. Due to the inherent chemotherapy and radiotherapy resistance and absence of known therapeutic…”
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CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice by Brennecke, Patrick, Arlt, Matthias J. E., Campanile, Carmen, Husmann, Knut, Gvozdenovic, Ana, Apuzzo, Tiziana, Thelen, Marcus, Born, Walter, Fuchs, Bruno

“…Current combined surgical and neo-adjuvant chemotherapy of primary metastatic osteosarcoma (OS) is ineffective, reflected by a 5-year survival rate of affected…”
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CD44 enhances tumor formation and lung metastasis in experimental osteosarcoma and is an additional predictor for poor patient outcome by Gvozdenovic, Ana, Arlt, Matthias JE, Campanile, Carmen, Brennecke, Patrick, Husmann, Knut, Li, Yufei, Born, Walter, Muff, Roman, Fuchs, Bruno

“…Formation of metastases in the lungs is the major cause of death in patients suffering from osteosarcoma (OS). Metastases at presentation and poor response to…”
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Cyr61 expression in osteosarcoma indicates poor prognosis and promotes intratibial growth and lung metastasis in mice by Sabile, Adam A, Arlt, Matthias JE, Muff, Roman, Bode, Beata, Langsam, Bettina, Bertz, Josefine, Jentzsch, Thorsten, Puskas, Gabor J, Born, Walter, Fuchs, Bruno

“…Osteosarcoma is the most frequent primary malignant bone tumor in children and adolescents with a high propensity for lung metastasis, the major cause of…”
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Antimetastatic activity of honokiol in osteosarcoma by Steinmann, Patrick, Walters, Denise K., Arlt, Matthias J. E., Banke, Ingo J., Ziegler, Urs, Langsam, Bettina, Arbiser, Jack, Muff, Roman, Born, Walter, Fuchs, Bruno

“…BACKGROUND: Metastasizing osteosarcoma has a mean 5‐year survival rate of only 20% to 30%. Therefore, novel chemotherapeutics for more effective treatment of…”
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Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice by Brennecke, Patrick, Arlt, Matthias J E, Muff, Roman, Campanile, Carmen, Gvozdenovic, Ana, Husmann, Knut, Holzwarth, Nathalie, Cameroni, Elisabetta, Ehrensperger, Felix, Thelen, Marcus, Born, Walter, Fuchs, Bruno

“…More effective treatment of metastasizing osteosarcoma with a current mean 5-year survival rate of less than 20% requires more detailed knowledge on mechanisms…”
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Altered CXCL12 expression reveals a dual role of CXCR4 in osteosarcoma primary tumor growth and metastasis by Neklyudova, Olga, Arlt, Matthias J. E., Brennecke, Patrick, Thelen, Marcus, Gvozdenovic, Ana, Kuzmanov, Aleksandar, Robl, Bernhard, Botter, Sander M., Born, Walter, Fuchs, Bruno

“…Purpose Better understanding of the molecular mechanisms of metastasis—the major cause of death in osteosarcoma (OS)—is a key for the development of more…”
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TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells by Cambria, Elena, Arlt, Matthias J E, Wandel, Sandra, Krupkova, Olga, Hitzl, Wolfgang, Passini, Fabian S, Hausmann, Oliver N, Snedeker, Jess G, Ferguson, Stephen J, Wuertz-Kozak, Karin

“…Mechanical loading and inflammation interact to cause degenerative disc disease and low back pain (LBP). However, the underlying mechanosensing and…”
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Silencing of CD44 gene expression in human 143-B osteosarcoma cells promotes metastasis of intratibial tumors in SCID mice by Gvozdenovic, Ana, Arlt, Matthias J E, Campanile, Carmen, Brennecke, Patrick, Husmann, Knut, Born, Walter, Muff, Roman, Fuchs, Bruno

“…Osteosarcoma (OS) is the most frequent primary malignant bone cancer in children and adolescents with a high propensity for lung metastasis. Therefore, it is…”
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Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells by Arlt, Matthias J.E., Born, Walter, Fuchs, Bruno

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Characterization of different osteosarcoma phenotypes by PET imaging in preclinical animal models by Campanile, Carmen, Arlt, Matthias J E, Krämer, Stefanie D, Honer, Michael, Gvozdenovic, Ana, Brennecke, Patrick, Fischer, Cindy R, Sabile, Adam A, Müller, Adrienne, Ametamey, Simon M, Born, Walter, Schibli, Roger, Fuchs, Bruno

“…The aim of this study was to characterize the different phenotypes of osteosarcoma by PET, comparing the uptake of 3 tracers ((18)F-FDG,…”
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