Search Results - "Arlett, C."

Elevated expression of artemis in human fibroblast cells is associated with cellular radiosensitivity and increased apoptosis by Ulus-Senguloglu, G, Arlett, C F, Plowman, P N, Parnell, J, Patel, N, Bourton, E C, Parris, C N

“…Background: The objective of this study was to determine the molecular mechanisms responsible for cellular radiosensitivity in two human fibroblast cell lines…”
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Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient by Riballo, E., Critchlow, S.E., Teo, S-H., Doherty, A.J., Priestley, A., Broughton, B., Kysela, B., Beamish, H., Plowman, N., Arlett, C.F., Lehmann, A.R., Jackson, S.P., Jeggo, P.A.

“…The major mechanism for the repair of DNA double-strand breaks (DSBs) in mammalian cells is non-homologous end-joining (NHEJ), a process that involves the…”
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A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase by Savitsky, Kinneret, Bar-Shira, Anat, Gilad, Shlomit, Rotman, Galit, Ziv, Yael, Vanagaite, Lina, Tagle, Danilo A., Smith, Sara, Uziel, Tamar, Sfez, Sharon, Ashkenazi, Maya, Pecker, Iris, Frydman, Moshe, Harnik, Reli, Patanjali, Sankhavaram R., Simmons, Andrew, Clines, Gregory A., Sartiel, Adam, Gatti, Richard A., Chessa, Luciana, Sanal, Ozden, Lavin, Martin F., Jaspers, N. G. J., A. Malcolm R. Taylor, Arlett, Colin F., Miki, Toru, Weissman, Sherman M., Lovett, Michael, Collins, Francis S., Shiloh, Yosef

“…A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) was identified by positional cloning on chromosome 11q22-23. AT is…”
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Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks by FORAY, A. PRIESTLEY, G. ALSBEIH, C. BADIE, E. P. CAPULAS, C. F. ARLETT and E. P. MALAISE, N.

“…We have studied the intrinsic radiosensitivity, repair of potentially lethal damage (PLD) and the repair rate of radiation-induced DNA double-strand breaks…”
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Risk of breast cancer and other cancers in heterozygotes for ataxia-telangiectasia by INSKIP, H. M, KINLEN, L. J, TAYLOR, A. M. R, WOODS, C. G, ARLETT, C. F

“…Mortality from cancer among 178 parents and 236 grandparents of 95 British patients with ataxia-telangiectasia was examined. For neither parents nor…”
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Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum by ARLETT, C. F, PLOWMAN, P. N, ROGERS, P. B, PARRIS, C. N, ABBASZADEH, F, GREEN, M. H. L, MCMILLAN, T. J, BUSH, C, FORAY, N, LEHMANN, A. R

“…XP14BR is a cell line derived from a xeroderma pigmentosum (XP) patient from complementation group C. The patient was unusual in presenting with an…”
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Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts by ARLETT, C. F, GREEN, M. H. L, LEHMANN, A. R, PLOWMAN, P. N

“…We have examined our ionizing radiation survival data for 33 xeroderma pigmentosum (XP) primary fibroblast lines and compared the data to that of 53 normal…”
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Neurological symptoms and natural course of xeroderma pigmentosum by Anttinen, Anu, Koulu, Leena, Nikoskelainen, Eeva, Portin, Raija, Kurki, Timo, Erkinjuntti, Matti, Jaspers, Nicolaas G. J., Raams, Anja, Green, Michael H. L., Lehmann, Alan R., Wing, Jonathan F., Arlett, Colin F., Marttila, Reijo J.

“…We have prospectively followed 16 Finnish xeroderma pigmentosum (XP) patients for up to 23 years. Seven patients were assigned by complementation analysis to…”
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Short Tandem Repeat Profiling Provides an International Reference Standard for Human Cell Lines by Masters, John R., Thomson, Jim A., Daly-Burns, Bernadette, Reid, Yvonne A., Dirks, Wilhelm G., Packer, Phil, Toji, Lorraine H., Ohno, Tadao, Tanabe, Hideyuki, Arlett, Colin F., Kelland, Lloyd R., Harrison, Maureen, Virmani, Arvind, Ward, Timothy H., Ayres, Karen L., Debenham, Paul G.

“…Cross-contamination between cell lines is a longstanding and frequent cause of scientific misrepresentation. Estimates from national testing services indicate…”
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Effects of selenium compounds on induction of DNA damage by broadband ultraviolet radiation in human keratinocytes by Rafferty, T.S., Green, M.H.L., Lowe, J.E., Arlett, C., Hunter, J.A.A., Beckett, G.J., McKenzie, R.C.

“…Summary Background Ultraviolet radiation (UVR), a ubiquitous environmental genotoxin for the skin, produces DNA damage. The trace element selenium induces…”
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Induction of Interleukin-6 Production by Ultraviolet Radiation in Normal Human Epidermal Keratinocytes and in a Human Keratinocyte Cell Line is Mediated by DNA Damage by Petit-FrèrePeter, Corinne, Clingen, Petit H., Arlett, Colin F., Green, Michael H.L., Grewe, Markus, Krutmann, Jean, Roza, Len

“…The sunburn reaction is the most common consequence of human exposure to ultraviolet radiation (UVR), and is mediated at least in part by interleukin-6 (IL-6)…”
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Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3 by VERMEULEN, W, SCOTT, R. J, RODGERS, S, MÜLLER, H. J, COLE, J, ARLETT, C. F, KLEIJER, W. J, BOOTSMA, D, HOEIJMAKERS, J. H. J, WEEDA, G

“…The human DNA excision repair gene ERCC3 specifically corrects the nucleotide excision repair (NER) defect of xeroderma pigmentosum (XP) complementation group…”
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The 0.8% ultraviolet B content of an ultraviolet A sunlamp induces 75% of cyclobutane pyrimidine dimers in human keratinocytes in vitro by WOOLLONS, A, KIPP, C, YOUNG, A. R, PETIT-FRERE, C, ARLETT, C. F, GREEN, M. H. L, CLINGEN, P. H

“…Tanning lamps, emitting predominantly ultraviolet (UV) A, are used widely throughout the U.K. and other countries, but little is known about the long‐term…”
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Apoptosis and cytokine release induced by ionizing or ultraviolet B radiation in primary and immortalized human keratinocytes by PETIT-FRERE, C, CAPULAS, E, LYON, D. A, NORBURY, C. J, LOWE, J. E, CLINGEN, P. H, RIBALLO, E, GREEN, M. H. L, ARLETT, C. F

“…We have compared the induction of apoptosis and cytokine release by UVB and gamma-radiation in primary (untransformed) and in two immortalized human…”
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Contrasting effects of an ultraviolet B and an ultraviolet A tanning lamp on interleukin-6, tumour necrosis factor-α and intercellular adhesion molecule-1 expression by Clingen, P.H., Berneburg, M., Petit-Frère, C., Woollons, A., Lowe, J.E., Arlett, C.F., Green, M.H.L.

“…Background Recent studies have demonstrated that a tanning lamp emitting predominantly ultraviolet (UV) A induces significant yields of the type of potentially…”
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Characterization of photosensitivity in the Smith-Lemli-Opitz syndrome: a new congenital photosensitivity syndrome by ANSTEY, A. V, RYAN, A, RHODES, L. E, CHARMAN, C. R, ARLETT, C. F, TYRRELL, R. M, TAYLOR, C. R, PEARSE, A. D

“…Photosensitivity has recently been reported as a feature of the Smith–Lemli–Opitz syndrome (SLO). The aim of this study was to establish the photobiological…”
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Underestimation of the small residual damage when measuring DNA double-strand breaks (DSB): is the repair of radiation-induced DSB complete? by Foray, C. F. Arlett, E. P. Malaise, N.

“…Purpose: To overcome the underestimation of the small residual damage when measuring DNA double-strand breaks (DSB) as fraction of activity released (FAR) by…”
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Induction and Rejoining of DNA Double-Strand Breaks and Interphase Chromosome Breaks after Exposure to X Rays in One Normal and Two Hypersensitive Human Fibroblast Cell Lines by Badie, C., Iliakis, G., Foray, N., Alsbeih, G., Cedervall, B., Chavaudra, N., Pantelias, G., Arlett, C., Malaise, E. P.

“…The aim of this work was to measure simultaneously and in a quantitative manner double-strand breaks (DSBs), interphase chromosome breaks and cell lethality…”
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Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: A closer look by Foray, N., Arlett, C.F., Malaise, E.P.

“…A large number of reports suggest that DNA double-strand breaks (DSB) play a major role in the radiation-induced killing of mammalian cells. However, the…”
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The use of dubious cell lines in research: is trust enough? by Arlett, C F

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